diff --git a/tests/run-tests.py b/tests/run-tests.py
index c218afae7194a..9ce34e130cc24 100755
--- a/tests/run-tests.py
+++ b/tests/run-tests.py
@@ -766,6 +766,7 @@ def run_tests(pyb, tests, args, result_dir, num_threads=1):
     # Some tests shouldn't be run on GitHub Actions
     if os.getenv("GITHUB_ACTIONS") == "true":
         skip_tests.add("thread/stress_schedule.py")  # has reliability issues
+        skip_tests.add("extmod/select_poll_eintr.py")  # has reliability issues
 
         if os.getenv("RUNNER_OS") == "Windows" and os.getenv("CI_BUILD_CONFIGURATION") == "Debug":
             # fails with stack overflow on Debug builds