diff --git a/Include/internal/pycore_gc.h b/Include/internal/pycore_gc.h
index a6519aa086309d..2f65ddd47076f1 100644
--- a/Include/internal/pycore_gc.h
+++ b/Include/internal/pycore_gc.h
@@ -133,7 +133,7 @@ static inline void _PyObject_GC_SET_SHARED(PyObject *op) {
 */
 #define _PyGC_NEXT_MASK_OLD_SPACE_1    1
 
-#define _PyGC_PREV_SHIFT           2
+#define _PyGC_PREV_SHIFT           _PyObject_ALIGNMENT_SHIFT
 #define _PyGC_PREV_MASK            (((uintptr_t) -1) << _PyGC_PREV_SHIFT)
 
 /* set for debugging information */
diff --git a/Include/internal/pycore_interp_structs.h b/Include/internal/pycore_interp_structs.h
index f25f5847b3b307..88df75c8774382 100644
--- a/Include/internal/pycore_interp_structs.h
+++ b/Include/internal/pycore_interp_structs.h
@@ -163,8 +163,9 @@ typedef struct {
 
     // Tagged pointer to previous object in the list.
     // Lowest two bits are used for flags documented later.
+    // Those bits are made available by the struct's minimum alignment.
     uintptr_t _gc_prev;
-} PyGC_Head;
+} PyGC_Head Py_ALIGNED(1 << _PyObject_ALIGNMENT_SHIFT);
 
 #define _PyGC_Head_UNUSED PyGC_Head
 
diff --git a/Include/object.h b/Include/object.h
index 994cac1ad17501..37b93679d34477 100644
--- a/Include/object.h
+++ b/Include/object.h
@@ -101,6 +101,11 @@ whose size is determined when the object is allocated.
 #define PyObject_VAR_HEAD      PyVarObject ob_base;
 #define Py_INVALID_SIZE (Py_ssize_t)-1
 
+/* PyObjects are given a minimum alignment so that the least significant bits
+ * of an object pointer become available for other purposes.
+ */
+#define _PyObject_ALIGNMENT_SHIFT       2
+
 /* Nothing is actually declared to be a PyObject, but every pointer to
  * a Python object can be cast to a PyObject*.  This is inheritance built
  * by hand.  Similarly every pointer to a variable-size Python object can,
@@ -142,7 +147,7 @@ struct _object {
 #endif
 
     PyTypeObject *ob_type;
-};
+} Py_ALIGNED(1 << _PyObject_ALIGNMENT_SHIFT);
 #else
 // Objects that are not owned by any thread use a thread id (tid) of zero.
 // This includes both immortal objects and objects whose reference count
@@ -160,7 +165,7 @@ struct _object {
     uint32_t ob_ref_local;      // local reference count
     Py_ssize_t ob_ref_shared;   // shared (atomic) reference count
     PyTypeObject *ob_type;
-};
+} Py_ALIGNED(1 << _PyObject_ALIGNMENT_SHIFT);
 #endif
 
 /* Cast argument to PyObject* type. */
diff --git a/Misc/NEWS.d/next/Build/2024-12-04-10-00-35.gh-issue-127545.t0THjE.rst b/Misc/NEWS.d/next/Build/2024-12-04-10-00-35.gh-issue-127545.t0THjE.rst
new file mode 100644
index 00000000000000..3667e2778b7b93
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2024-12-04-10-00-35.gh-issue-127545.t0THjE.rst
@@ -0,0 +1 @@
+Fix crash when building on Linux/m68k.