diff --git a/mypyc/irbuild/statement.py b/mypyc/irbuild/statement.py
index b109d925558b..16a0483a8729 100644
--- a/mypyc/irbuild/statement.py
+++ b/mypyc/irbuild/statement.py
@@ -940,6 +940,10 @@ def emit_yield_from_or_await(
     # If it wasn't, this reraises the exception.
     builder.activate_block(stop_block)
     builder.assign(result, builder.call_c(check_stop_op, [], line), line)
+    # Clear the spilled iterator/coroutine so that it will be freed.
+    # Otherwise, the freeing of the spilled register would likely be delayed.
+    err = builder.add(LoadErrorValue(object_rprimitive))
+    builder.assign(iter_reg, err, line)
     builder.goto(done_block)
 
     builder.activate_block(main_block)