ACBU

A lower incidence of dysplastic lesions was revealed in both AcBu supplemented groups: sub groups with 17 inoculations (n=50) and the other with 5 inoculations (n=14).

The decrease of precarcinomatous lesions development could due to the pure AcBu use at high concentrations during a long time exposure.

sub-group DMH - 17 AcBu + DMH - 17 number of rats n = 20 n = 19 number dysplastic lesions 117 50 rectum 2 (1.71%) 2 (4%) distal colon 68 (58.12%) 34 (68%) proximal colon 34 (29.06%) 12 (24%) cecum 13 (11.11%) 2 (4%) () Percentage over total of dysplastic lesions in each sub-group.