D6D

Haplotype reconstruction may be of particular importance in studies looking at insulin resistance measures or diabetes risk as D5D (FADS1) and D6D (FADS2) activities have been shown to have an opposite relationship with diabetes risk.

Our study did not collect dietary data or individually measure D5D and D6D fatty acid indices and these important measures should be taken into account in future studies.

D6D is an enzyme of particular importance to the metabolism of fats.

Deficiencies of biotin, vitamin E, protein, zinc, B12, and B6 also interfere with the action of D6D and other enzymes involved in prostaglandin production.

One way to ensure adequate GLA intake is to bypass the D6D enzyme and supply GLA directly through the diet.

The authors hypothesized that immature functioning of the D6D enzyme may be responsible for ISD in this population and can be corrected with GLA in the form of borage oil.