OAT1

AcronymDefinition
OAT1Organic Anion Transporter 1
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Several studies have also demonstrated that specific protein kinases could differentially modulate Oat1 and 3 transports of organic anions.
As mentioned earlier, renal Oat1 and 3 were influenced by certain pathological status and strongly correlated with the progression of diabetic kidney diseases [16] and para-aminohippurate (PAH) is a prototypical substrate for rOat1 and 3 transporters that are mainly localized on the basolateral membrane of renal proximal tubules [8, 9, 11].
Antidiabetic and renoprotective effects of Cladophora glomerata Kutzing extract in experimental type 2 diabetic rats: a potential nutraceutical product for diabetic nephropathy
One change from the ITC white paper is that all investigational drugs should be evaluated as inhibitors of the renal uptake transporters OCT2, OAT1, OATS, without regard to likely co-medications; the white paper recommended evaluating new drugs as inhibitors of one of these transporters if they were likely to be co-administered with a substrate of the same transporter.
Drug interaction studies: a new FDA draft guidance reflects a fast-changing field
(2007) Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats.
The nephrotoxicity risk in rats subjected to heavy muscle activity
For rat kidneys, androgen-dependent expression of Oat1, Oat3, and Oct2 and higher expression of Oat2 in females was reported, suggesting sex-dependent renal drug handling at least in this species [12, 13].
Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats
KEY WORDS: gold mining, inorganic mercury, LAT1, MDR1, MRP1, OAT1, OAT3, SLC3A2, SLC22A6, SLC22A8.
Polymorphisms in genes encoding potential mercury transporters and urine mercury concentrations in populations exposed to mercury vapor from gold mining
Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition.
Half-Life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
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