VDSS

The calibration and validation of the models are based on the data of target VDSs from May and November of 2013.

The following pharmacokinetic equations were used for different calculations: Dose=Cl x AUC Cl = Dose/AUC; AUMC = MRT x AUC; Dose = VDss X AUC2 AUMC; VD=Dose/Kel x AUC VD = Dose/concentration measured in plasma;VDss= Cl x MRT

Em relacao ao volume de distribuicao, puderam-se observar valores altos de V3 e Vdss (Tabela 1), o que demonstra uma elevada distribuicao tecidual do propofol.

The reported means PK- values in donkeys were AUC 4.6 ug/mL/h, MRT 0.6 h, Cl 0.188 mL/kg/h, VDSS was 0.093L/kg.

VDss L/kg-1 (l/kg)###0.2324-0.3321###.267+0.014###0.0408###15.28###0.255

Just under the wire, the six copies of the grant application were delivered to VDSS in Richmond.

(7) The note on Village Design Statements has helped to inform the production of several VDSs in the North East.

Vdss = 2,5 L/7 Kg; excrecion hepatica; T1/2[beta] = 10,2 h..

The data obtained the mean (+SEM) pharmacokinetic parameters of ketoprofen were, AUC (Area under the curve) = 17.02-+2.61 g.h/ml, Cl (clearance) = 0.21-+0.02l/h/kg, VDss (Steady state volume of distribution) = 0.47-+0.04 l/kg, t1/2 (half life) = 2.2-+ 0.17h, and MRT (Mean Residence Time) = 2.44-+0.17 hrs.

Version 3.02, as Mean +-SEM AUC (Area Under the concentration time Curve) +- ug.h.ml-1, Cl (Clearance) +- l.hr-1.kg-1, t1/2 (Half Life) +- hr-1, VD (Volume of Distribution) +- l.kg-1, VDss (Volume of distribution at Steady State) +- l.kg-1, and Kel (Elimination Rate Constant) +- l.hr-1 respectively.