RRP1B, skraćena verzija od homolog B proteina 1 kodiranog prerađenom ribosomskom RNK, znan i kao KIAA0179, jest ljudski gen sa hromosoma 21.[5]

RRP1B
Identifikatori
AliasiRRP1B
Vanjski ID-jeviOMIM: 610654 MGI: 1919712 HomoloGene: 57086 GeneCards: RRP1B
Lokacija gena (čovjek)
Hromosom 21 (čovjek)
Hrom.Hromosom 21 (čovjek)[1]
Hromosom 21 (čovjek)
Genomska lokacija za RRP1B
Genomska lokacija za RRP1B
Bend21q22.3Početak43,659,560 bp[1]
Kraj43,696,079 bp[1]
Lokacija gena (miš)
Hromosom 17 (miš)
Hrom.Hromosom 17 (miš)[2]
Hromosom 17 (miš)
Genomska lokacija za RRP1B
Genomska lokacija za RRP1B
Bend17|17 B1Početak32,255,074 bp[2]
Kraj32,281,839 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija vezivanje sa RNK
GO:0001105 transcription coactivator activity
GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta GO:0035328 heterochromatin
preribosome, small subunit precursor
citosol
GO:0035327 euchromatin
Jedarce
jedro
preribosome, large subunit precursor
granular component
nukleoplazma
hromosom
Biološki proces negative regulation of phosphatase activity
rRNA processing
GO:0034259 negative regulation of GTPase activity
positive regulation of apoptotic process
regulation of RNA splicing
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
cellular response to virus
mRNA processing
GO:0097285 apoptoza
Prerada RNK
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_015056

NM_001163734
NM_028244

RefSeq (bjelančevina)

NP_055871

NP_001157206
NP_082520

Lokacija (UCSC)Chr 21: 43.66 – 43.7 MbChr 17: 32.26 – 32.28 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 758 aminokiselina, a molekulska težina 84.428 Da.[5]

1020304050
MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEE
LLKIWKGLFYCMWVQDEPLLQEELANTIAQLVHAVNNSAAQHLFIQTFWQ
TMNREWKGIDRLRLDKYYMLIRLVLRQSFEVLKRNGWEESRIKVFLDVLM
KEVLCPESQSPNGVRFHFIDIYLDELSKVGGKELLADQNLKFIDPFCKIA
AKTKDHTLVQTIARGVFEAIVDQSPFVPEETMEEQKTKVGDGDLSAEEIP
ENEVSLRRAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTGPLLQFDY
KAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDIS
ADEDDQILSQGKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRR
RKKKKKHHLQPENPGPGGAAPSLEQNRGREPEASGLKALKARVAEPGAEA
TSSTGEESGSEHPPAVPMHNKRKRPRKKSPRAHREMLESAVLPPEDMSQS
GPSGSHPQGPRGSPTGGAQLLKRKRKLGVVPVNGSGLSTPAWPPLQQEGP
PTGPAEGANSHTTLPQRRRLQKKKAGPGSLELCGLPSQKTASLKKRKKMR
VMSNLVEHNGVLESEAGQPQALGSSGTCSSLKKQKLRAESDFVKFDTPFL
PKPLFFRRAKSSTATHPPGPAVQLNKTPSSSKKVTFGLNRNMTAEFKKTD
KSILVSPTGPSRVAFDPEQKPLHGVLKTPTSSPASSPLVAKKPLTTTPRR
RPRAMDFF

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160208 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058392 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: KIAA0179 KIAA0179".

Dopunska literatura

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