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Commercialization of plant-based vaccines from research and development to manufacturing

Published online by Cambridge University Press:  28 February 2007

John A. Howard
John A. Howard*
Affiliation:
Biotechnology Institute, 5819 Stallion Ridge, College Station, TX 77845, USA
*
E-mail: jhoward999@appliedbiotech.org
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Abstract

The benefits of using plant-based oral vaccines are discussed. Transgenic maize expressing an antigen of transmissible gastroenteritis virus (TGEV) is reported as a model to demonstrate efficacy. Young pigs that were fed the TGEV corn orally were protected against challenge with virulent TGEV. Additional parameters important in providing a reliable and consistent supply of plant-based vaccines are discussed. Finally, vaccines developed in maize are evaluated for their potential to contaminate either the food supply or the environment.

Keywords

plant-based vaccinescommercialization
Type
Research Article
Information
Animal Health Research Reviews , Volume 5 , Issue 2 , December 2004 , pp. 243 - 245
Copyright
Copyright © CAB International 2004

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References

Hood, EE, Witcher, DR, Maddock, S, Meyer, T, Baszczynski, C, Bailey, M, Flynn, P, Register, J, Marshall, L, Bond, D, Kulisek, E, Kusnadi, A, Evangelista, R, Nikolov, Z, Wooge, C, Mehigh, RJ, Herman, R, Kappel, WK, Ritland, D, Li, CP and Howard, JA (1997). Commercial production of avidin from transgenic maize: characterization of transformant, production, processing, extraction and purification. Molecular Breeding 3: 291–306.CrossRefGoogle Scholar
Jilka, JM, Hood, EE, Dose, R and Howard, J (1999). The benefits of proteins produced in transgenic plants. [Review]. AgBiotechNet 1: ABN 027.Google Scholar
Kusnadi, AR, Nikolov, ZL and Howard, JA (1997). Production of recombinant proteins in transgenic plants: practical considerations. Biotechnology and Bioengineering 56: 473–484.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Lamphear, BJ, Streatfield, SJ, Jilka, JM, Brooks Barker, DK, Turner, DD, Delaney, E, Garcia, M, Wiggins, B, Woodard, SL, Hood, EE, Tizard, IR, Lawhorn, B and Howard, JA (2002). Delivery of subunit vaccines in maize seed. Journal of Controlled Release 85: 169–180.CrossRefGoogle ScholarPubMed
Laude, H, Rasschaert, D, Delmas, B, Godet, M, Gelfi, J and Charley, B (1990). Molecular biology of transmissible gastroenteritis virus. Veterinary Microbiology 23: 147–154.CrossRefGoogle ScholarPubMed
Ma, JK-C, Drake, PMW and Christou, P (2003). The production of recombinant pharmaceutical proteins in plants. Nature Reviews, Genetics 4: 794–805.CrossRefGoogle ScholarPubMed
Streatfield, SJ and Howard, JA (2003). Plant-based vaccines. International Journal for Parasitology 33: 479–493.CrossRefGoogle ScholarPubMed
Streatfield, SJ, Jilka, JM, Hood, EE, Turner, DD, Bailey, MR, Mayor, JM, Woodard, SL, Beifuss, KK, Horn, ME, Delaney, DE, Tizard, IR and Howard, JA (2001). Plant-based vaccines: unique advantages. Vaccine 19: 2742–2748.CrossRefGoogle ScholarPubMed
Streatfield, SJ, Mayor, JM, Barker, DK, Brooks, C, Lamphear, BJ, Woodard, SL, Beifuss, KK, Vicuna, DV, Massey, LA, Horn, ME, Delaney, DE, Nikolov, ZL, Hood, EE, Jilka, JM and Howard, JA (2002). 2000 Congress Symposium on Molecular Farming: Development of an edible subunit vaccine in corn against enterotoxigenic strains of Escherichia coli. In Vitro Cellular Developmental Biology Plant 38: 11–17.CrossRefGoogle Scholar
Streatfield, S, Lane, JR, Brooks, CA, Barker, DK, Poage, ML, Mayor, JM, Lamphear, BJ, Drees, CF, Jilka, JM, Hood, EE and Howard, JA (2003). Corn as a production system for human and animal vaccines. Vaccine 21: 812–815.CrossRefGoogle Scholar
Witcher, DR, Hood, EE, Peterson, D, Bailey, M, Bond, D, Kusnadi, A, Evangelista, R, Nikolov, Z, Wooge, C, Mehigh, R, Kappel, W, Register, J and Howard, JA (1998). Commercial production of β-glucuronidase (GUS): a model system for the production of proteins in plants. Molecular Breeding 4: 301–312.CrossRefGoogle Scholar
Woodard, SL, Mayor, JM, Bailey, MR, Barker, DK, Love, RT, Lane, JR, Delaney, DE, McComas-Wagner, JM, Mallubhotla, HD, Hood, EE, Gangott, LJ, Tichy, SE and Howard, JA (2003). Maize (Zea mays) -derived bovine trypsin: characterization of the first large-scale, commercial product from transgenic plants. Biotechnology and Applied Biochemistry 38: 123–130.CrossRefGoogle ScholarPubMed