I searched this article trying to understand the difference between an oncogene and a protooncogene. Their definition seem the same to me in this article, just with slightly different words. <span style="font-size: smaller;" class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/201.66.199.182|201.66.199.182]] ([[User talk:201.66.199.182|talk]]) 23:44, 31 January 2009 (UTC)</span><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->
:historically, when oncogenesthe first oncogene wherewas discovered, the discovered gene becambecame tumour inducing from the inserstioninsertion of viral DNA. Oncogene then meant the mutated version and proto-oncogene the non-mutated version. However, as it was found that upregulation led in some cases to oncogenic behaviour from completely un-mutated "proto"-oncogene, some authors do not make the distinction. I believe there is still debate about what is correct. My personal ''opinion'' which has no authority at all is that it makes no sense to have two names for the exact same strand of DNA.[[User:CyrilleDunant|CyrilleDunant]] ([[User talk:CyrilleDunant|talk]]) 08:15, 1 February 2009 (UTC)
