Chlormadinone

Chlormadinone
Clinical data
Other names	Chlordione; 17α-Hydroxy-6-chloro-6-dehydroprogesterone; 17α-Hydroxy-6-chloropregna-4,6-diene-3,20-dione; 6-Chloro-17α-hydroxypregna-4,6-diene-3,20-dione
ATC code	G03DB06 (WHO) ;
Identifiers
	IUPAC name (8R,9S,10R,13S,14S,17R)-17-acetyl-6-chloro-17-hydroxy-10,13-dimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one;
CAS Number	1961-77-9;
PubChem CID	5284533;
ChemSpider	4447590;
UNII	SDS4N642GG;
CompTox Dashboard (EPA)	DTXSID3022796 ;
ECHA InfoCard	100.016.185
Chemical and physical data
Formula	C21H27ClO3
Molar mass	362.89 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C4\C=C3\C(\Cl)=C/[C@@H]1[C@H](CC[C@@]2([C@@](O)(C(=O)C)CC[C@@H]12)C)[C@@]3(C)CC4;
	InChI InChI=1S/C21H27ClO3/c1-12(23)21(25)9-6-16-14-11-18(22)17-10-13(24)4-7-19(17,2)15(14)5-8-20(16,21)3/h10-11,14-16,25H,4-9H2,1-3H3/t14-,15+,16+,19-,20+,21+/m1/s1; Key:VUHJZBBCZGVNDZ-TTYLFXKOSA-N;

Chlormadinone is a progestin which was never marketed.^[1]^[2] An acylated derivative, chlormadinone acetate, is used clinically as a pharmaceutical drug.^[1]^[2]

It was patented in 1958 and approved for medical use in 1963.^[3] While chlormadinone is sometimes used as a synonym for chlormadinone acetate, what is almost always being referred to is chlormadinone acetate and not chlormadinone.

References

^ ^a ^b Macdonald F (1997). Dictionary of Pharmacological Agents. CRC Press. p. 419. ISBN 978-0-412-46630-4. Retrieved 29 May 2012.
^ ^a ^b Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 215. ISBN 978-3-88763-075-1. Retrieved 29 May 2012.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 478. ISBN 9783527607495.

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[Macdonald1997-1] Macdonald F (1997). Dictionary of Pharmacological Agents. CRC Press. p. 419. ISBN 978-0-412-46630-4. Retrieved 29 May 2012.

[IndexNominum2000-2] Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 215. ISBN 978-3-88763-075-1. Retrieved 29 May 2012.

[Fis2006-3] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 478. ISBN 9783527607495.

[1]

[2]

[3]

Chlormadinone

See also

References