This article lists the ministers of foreign relations of Uruguay since 1828:
| Minister | Term of office |
|---|---|
| Juan Francisco Giró | December 22, 1828 – August 27, 1829 |
| Fructuoso Rivera | December 16, 1829 – January 18, 1830 |
| Juan Antonio Lavalleja | January 18, 1830 – March 11, 1830 |
| José Longinos Ellauri | March 11, 1830 – April 20, 1830 |
| Juan Francisco Giró | April 20, 1830 – October 24, 1830 |
| José Longinos Ellauri | November 11, 1830 – September 2, 1831 |
| Joaquín Suárez | September 19, 1831 – November 7, 1831 |
| Santiago Vázquez | November 7, 1831 – July 5, 1832 |
| Francisco Joaquín Muñoz | July 5, 1832 – August 16, 1832 |
| Santiago Vázquez | August 16, 1832 – October 9, 1833 |
| Francisco Llambí | October 9, 1833 - December 20, 1833 |
| Lucas J. Obes | December 20, 1833 – January 7, 1835 |
| Francisco Llambí | March 4, 1835 – October 15, 1835 |
| Francisco Llambí | November 16, 1835 – March 27, 1837 |
| Juan Benito Blanco | August 6, 1837 – July 30, 1838 |
| Carlos Jerónimo Villademoros | September 1, 1838 – October 24, 1838 |
| Alejandro Chucarro | October 24, 1838 – November 11, 1838 |
| Foreign Relations Ministers of the Gobierno de la Defensa | |
| Santiago Vázquez | November 11, 1838 – February 6, 1839 |
| José Longinos Ellauri | February 6, 1839 – October 19, 1839 |
| Francisco Antonino Vidal | October 19, 1839 – February 3, 1843 |
| Santiago Vázquez | February 3, 1843 – April 6, 1846 |
| Francisco Magariños | April 6, 1846 – December 21, 1846 |
| Alejandro Chucarro | February 6, 1847 – July 5, 1847 |
| Miguel Barreiro | July 5, 1847 – August 11, 1847 |
| Manuel Herrera y Obes | August 11, 1847 – February 16, 1852 |
| Foreign Relations Ministers of the Gobierno del Cerrito | |
| Carlos Villademoros | February 17, 1843 – April 14, 1843 |
| Carlos Villademoros | May 12, 1843 – October, 1851 |
| Post–War Foreign Relations Ministers | |
| Florentino Castellanos | March 3, 1852 – July 4, 1853 |
| Bernardo Prudencio Berro | July 4, 1853 – September 24, 1853 |
| Juan Carlos Gómez | September 26, 1853 – November 9, 1853 |
| Juan José Aguiar | November 9, 1853 – February 8, 1854 |
| Mateo Magariños Cervantes | March 14, 1854 – November 20, 1854 |
| Francisco Hordeñana | November 20, 1854 – February 17, 1855 |
| Alejandro Chucarro | February 17, 1855 – May 30, 1855 |
| Manuel Herrera y Obes | August 31, 1855 – September 12, 1855 |
| Alfredo Rodríguez | September 28, 1855 – November 13, 1855 |
| Antonio Rodríguez Caballero | December 3, 1855 – January 18, 1856 |
| Alberto Flangini | January 24, 1856 – March 3, 1856 |
| Joaquín Requena | March 20, 1856 – January 4, 1858 |
| Antonio de las Carreras | January 4, 1858 – June 12, 1858 |
| Antonio de las Carreras | July 24, 1859 – March 1, 1860 |
| Eduardo Acevedo | March 8, 1860 – June 3, 1861 |
| Enrique de Arrascaeta | June 20, 1861 – June 23, 1862 |
| Jaime Estrázulas | September 18, 1862 – November 6, 1862 |
| Juan José de Herrera | October 12, 1863 – September 7, 1864 |
| Antonio de las Carreras | September 7, 1864 – February 15, 1865 |
| Carlos de Castro | February 27, 1865 – April 27, 1865 |
| Carlos de Castro | May 20, 1865 – May 15, 1866 |
| José Eugenio Ellauri | March 1, 1868 – March 8, 1868 |
| Alberto Flangini | May 15, 1866 – February 15, 1868 |
| Manuel Herrera y Obes | August 31, 1868 – September 12, 1868 |
| Alejandro Magariños Cervantes | January 14, 1869 – March 12, 1869 |
| Alfredo Rodríguez | June 15, 1869 – August 11, 1870 |
| Manuel Herrera y Obes | September 30, 1870 – February 28, 1872 |
| Ernesto Velazco | February 28, 1872 – July 30, 1872 |
| Julio Herrera y Obes | July 31, 1872 – September 8, 1872 |
| Gregorio Pérez Gomar | March 1, 1873 – January 15, 1875 |
| José Cándido Bustamante | January 15, 1875 – July 31, 1875 |
| Mateo Magariños Cervantes | February 22, 1876 – March 10, 1876 |
| Andrés Lamas | July 31, 1875 – February 22, 1876 |
| Ambrosio Velazco | March 15, 1876 – September 24, 1877 |
| Gualberto Méndez | September 24, 1877 – March 13, 1880 |
| Joaquín Requena y García | March 20, 1880 – March 26, 1881 |
| José Vázquez Sagastume | August 8, 1881 – February 28, 1882 |
| Manuel Herrera y Obes | March 8, 1882 – October 11, 1882 |
| Manuel Herrera y Obes | December 12, 1882 – March 1, 1886 |
| Manuel Herrera y Obes | May 28, 1886 – October 30, 1886 |
| Juan Carlos Blanco Fernández | November 3, 1886 – December 23, 1886 |
| Domingo Mendilaharsu | December 31, 1886 – April 4, 1887 |
| Ildefonso García Lagos | July 9, 1887 – November 21, 1889 |
| Blas Vidal | March 11, 1890 – December 17, 1890 |
| Manuel Herrero y Espinosa | March 2, 1891 – October 21, 1891 |
| Manuel Herrero y Espinosa | February 22, 1892 – November 14, 1893 |
| Luis Piñeyro del Campo | March 29, 1894 – August 3, 1894 |
| Jaime Estrázulas | September 17, 1894 – September 26, 1896 |
| Mariano Ferreira | August 28, 1897 – December 1, 1897 |
| Joaquín de Salterain | December 1, 1897 – July 21, 1898 |
| Domingo Mendilaharsu | August 3, 1898 - September 10, 1898 |
| Manuel Herrero y Espinosa | March 4, 1899 – June 4, 1901 |
| Germán Roosen | June 19, 1901 – February 25, 1903 |
| José Romeu | March 5, 1903 – March 1, 1907 |
| Jacobo Varela Acevedo | March 16, 1907 – November 14, 1907 |
| Antonio Bachini | December 2, 1907 – October 18, 1910 |
| José Romeu | March 4, 1911 – June 17, 1913 |
| Emilio Barbaroux | June 17, 1913 – February 13, 1914 |
| Manuel Buenaventura Otero | March 2, 1915 – August 14, 1916 |
| Baltasar Brum | September 4, 1916 – February 19, 1919 |
| Daniel Muñoz | February 19, 1919 – August 1, 1919 |
| Juan Antonio Buero | March 1, 1919 – March 1, 1923 |
| Pedro Manini Ríos | March 1, 1923 – December 19, 1924 |
| Juan Carlos Blanco Acevedo | December 22, 1924 – July 2, 1926 |
| Rufino T. Domínguez | March 1, 1927 – March 1, 1931 |
| Juan Carlos Blanco Acevedo | March 1, 1931 – February 13, 1933 |
| Alberto Mañé | February 13, 1933 – May 17, 1934 |
| Juan José de Arteaga | May 18, 1934 – October 4, 1934 |
| Juan José de Arteaga | November 6, 1934 – March 19, 1935 |
| José Espalter | March 19, 1935 – June 1, 1938 |
| Alberto Guani | June 19, 1938 – January 10, 1942 |
| Alberto Guani | February 18, 1942 – January 16, 1943 |
| Alberto Guani | February 25, 1943 – February 26, 1943 |
| José Serrato | March 1, 1943 – October 4, 1945 |
| Eduardo Rodríguez Larreta | October 4, 1945 – March 1, 1947 |
| Mateo Marques Castro | March 1, 1947 – December 12, 1947 |
| Daniel Castellanos | December 31, 1947 – August 12, 1949 |
| César Charlone | August 12, 1949 – November 23, 1950 |
| Alberto Domínguez Cámpora | November 23, 1950 – March 1, 1952 |
| Daniel Castellanos | March 1, 1952 – April 22, 1952 |
| Fructuoso Pittaluga | April 22, 1952 – February 23, 1955 |
| Santiago Rompani | March 2, 1955 – May 16, 1956 |
| Francisco Gamarra | May 16, 1956 – June 6, 1957 |
| Óscar Secco Ellauri | June 6, 1957 – March 1, 1959 |
| Homero Martínez Montero | March 1, 1959 – March 1, 1963 |
| Alejandro Zorrilla de San Martín | March 1, 1963 – February 11, 1965 |
| Luis Vidal Zaglio | February 11, 1965 – March 1, 1967 |
| Héctor Luisi | March 1, 1967 – April 25, 1968 |
| Venancio Flores | May 3, 1968 – April 1, 1970 |
| Jorge Peirano Facio | April 1, 1970 – April 1, 1971 |
| José Antonio Mora | April 1, 1971 – June 2, 1972 |
| Juan Carlos Blanco Estradé | October 31, 1972 – December 23, 1976 |
| Alejandro Rovira | December 23, 1976 – July 6, 1978 |
| Adolfo Folle Martínez | July 6, 1978 – February 16, 1981 |
| Estanislao Valdés Otero | February 17, 1981 – September 2, 1982 |
| Carlos A. Maeso | September 2, 1982 – March 1, 1985 |
| Enrique Iglesias | March 1, 1985 – February 22, 1988 |
| Luis Barrios Tassano | February 22, 1988 – February 28, 1990 |
| Héctor Gros Espiell | March 1, 1990 – April 4, 1993 |
| Sergio Abreu Bonilla | April 4, 1993 – March 1, 1995 |
| Álvaro Ramos Trigo | March 1, 1995 – February 1, 1998 |
| Didier Opertti Badán | February 2, 1998 – March 1, 2005 |
| Reinaldo Gargano | March 1, 2005 – March 3, 2008 |
| Gonzalo Fernández | March 3, 2008 – August 31, 2009 |
| Pedro Vaz | August 31, 2009 – March 1, 2010 |
| Luis Almagro | March 1, 2010 – March 1, 2015 |
| Rodolfo Nin Novoa | March 1, 2015 – March 1, 2020 |
| Ernesto Talvi | March 1, 2020 – July 1, 2020 |
| Francisco Bustillo | July 6, 2020 – November 1, 2023 |
| Omar Paganini | November 6, 2023 – present |