Peptidiltransferaza
Peptidiltransferaza (EC 2.3.2.12, transpeptidaza, ribosomalna peptidiltransferaza) je enzim sa sistematskim imenom peptidil-tRNK:aminoacil-tRNK N-peptidiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Peptidiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.2.12 | ||||||||
| CAS broj | 9059-29-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- peptidil-tRNK1 + aminoacil-tRNK2 tRNK1 + peptidil(aminoacil-tRNK2)
Ovaj enzim je ribozim. Dve neekvivantne ribonukleoproteinske podjednice deluju na neusaglažen način pri peptidnoj elongaciji.
Reference
uredi- ↑ Rychlik, I. (1966). „Release of lysine peptides by puromycin from polylysyl-transfer ribonucleic acid in the presence of ribosomes”. Biochim. Biophys. Acta 114: 425-427. PMID 5329275.
- ↑ Rychlik, I., Cerná, J., Chládek, S., Zemlicka, J. and Haladová, Z. (1969). „Substrate specificity of ribosomal peptidyl transferase: 2′(3′)-O-aminoacyl nucleosides as acceptors of the peptide chain on the amino acid site”. J. Mol. Biol. 43: 13-24. PMID 4897787.
- ↑ Traut, R.R. and Monro, R.E. (1964). „The puromycin reaction and its relation to protein synthesis”. J. Mol. Biol. 10: 63-72.
- ↑ Voorhees, R.M., Weixlbaumer, A., Loakes, D., Kelley, A.C. and Ramakrishnan, V. (2009). „Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome”. Nat. Struct. Mol. Biol. 16: 528-533. PMID 19363482.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.