Klobenpropit
Klobenpropit je histaminski antagonist H3 receptora.[1] On ima neuroprotektivno dejstvo, koje ostvaruje putem stimulacije otpuštanja gama-aminobuterne kiseline u mozgu.[2]
 | |
| IUPAC ime | |
|---|---|
N'-[(4-hlorofenil)metil]-1-[3-(3H-imidazol-4-il)propilsulfanil]formamidin | |
| Identifikatori | |
| CAS broj | 145231-45-4  |
| ATC kod | none |
| PubChem | CID 2790 |
| IUPHAR/BPS | 1223 |
| ChemSpider | 2688 |
| ChEMBL | CHEMBL14690 |
| Hemijski podaci | |
| Formula | C14H17ClN4S |
| Molarna masa | 308,83 g/mol |
| |
Reference
уреди- ^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). „The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes”. Eur. J. Pharmacol. 567 (3): 206—10. PMID 17537431. doi:10.1016/j.ejphar.2007.04.032.
- ^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613
