homeobox

This study demonstrated that the expression of HOXB7, HOXC6, and HOXC8 is differentially expressed in VW-MPSCs as compared to terminally differentiated human aortic smooth muscle cells, endothelial cells, and undifferentiated pluripotent ESCs.

Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer.

HOXC6 Down-regulation of HOXC6 due to decreased proliferation rates of cell line and the over-expression of it rescues the cells from apoptosis in prostate cancer (60).

The initial study by Thompson et al (307) found that ALK+ ALCL overexpresses genes encoding signal transduction molecules such as SYK, LYN, and CDC37 and underexpresses transcription factors such as HOXC6 and HOXA3; both ALK+ and ALK- ALCL highly express kinase genes (LCK, protein kinase C, VAV2, and NKIAMRE) and antiapoptotic molecules.