Concerns that anti-CTLA4 or PD-1 therapy would worsen their autoimmune disease or place them at an increased risk of developing
irAE are certainly valid.
He cited a recent systematic review and meta-analysis showing that among patients treated with any anti-CTLA-4, the overall incidence of all-grade
irAEs was 72%, and the overall incidence of high-grade
irAEs was 24%.
Given the incidence of
irAEs, a standard set of management guidelines were developed throughout the course of clinical development of ipilimumab [39].
In the context of a suspected drug-induced RTA secondary to nivolumab
irAE, the patient was started on dexamethasone 4 mg every 8 hrs and her fluid rate was increased to target administration of 3 mmol/kg/day of bicarbonate.
2 "Dies
Irae" and more restrained in terms of instrumentation than Johannes Kalitzke's Schuberts Traum.
The famous choral setting of Dies
Irae - the Day of Wrath - was performed with visceral conviction, with pounding drums and blasting trumpets ringing out from the back of the hall.
Requiem is almost a misnomer since the work consists of only an Introit, Kyrie and a multi-sectioned Sequence, beginning with the Dies
Irae and ending with the lacrimosa; missing are the usual Offertory, Sanctus, Agnus Dei and closing Requiem sections.
Bethabet explained that the press published the first preliminary results of the Independent Regional Authority for the Election (
IRAE) which then presented its report to the central authority which, in turn, recounted the votes, by taking into consideration the spoilt ballots in the electoral coefficient.
It is hard to imagine that a more dramatic piece of choral music could be conceived and composed than the Dies
Irae that is the heart of the work.
Bunch's other composition for the Ahn Trio, "Dies Irie," ironically references not the traditional Requiem Dies
Irae but the Jamaican patois phrase meaning, "Day of Everything Being Just Right." So that rage evaporates into sweetness and beguiling rhythms, with a delicious ending fadeout.
The organ imported for the occasion - an electronic instrument - lacked the force of a "real" instrument, but he coaxed from it some interesting and atmospheric sounds but it really could not compete with the might of an orchestra at full pelt in a movement like the Dies
Irae.
"I have, by and large, followed the traditional form of the requiem mass, including almost the entirety of the Dies
Irae which I have adapted to flamenco songs."
The fifth and final movement, McQuillen writes, moves through the ancient Latin Dies
Irae (Day of Wrath), ``along with more music of terror and anguish,'' into Friedrich Klopstock's hymn "Auferstehung (Resurrection)," which was sung in 1894 during the memorial service for Mahler's colleague, pianist and conductor Hans von Bulow.
