FOOD & DRUG ADMIN., http://www.fda.gov/ForConsumers/byAudienee/ForPatient Advocates/HIVandAIDSActivities/ucm118915.htm (last visited June 3, 2013) (listing a number of HIV drugs approved after January 1, 2005, including Edurant, extended-release
Viramune XR, and combination drug Stribild.
Nevirapine (
Viramune) for the study was provided by Boehringer Ingelheim Pharmaceuticals, Inc.
Adams is most notably known for discovering and developing two first-in-class drugs: VELCADE (Millennium) and
Viramune (Boehringer Ingelheim) and this year was recognized by PharmaVOICE as one of the "top 100 most inspirational and influential people in the life sciences industry."
Table 1 Common Antiretroviral Drugs (14-16) Classification Generic Name Trade Name Nucleoside reverse Abacavir sulfate Ziagen transcriptase inhibitors Abacavir sulfate + Trizivir (NRTI) lamivudine + zidovudine Didanosine (ddl) Videx, Videx EC Lamivudine (3TC) Epivir Lamiudine + zidovudine Combivir Stavudine (d4T) Zerit Tenofovir disoproxil Viread fumarate Zalcitabine (ddC) Hivid Zidovudine (AZT, ZDV) Retrovir Non-nucleoside reverse Delavirdine mesylate Rescriptor transcriptase inhibitors Efavirenz Sustiva (NNRTI) Nevirapine
Viramune Protease inhibitors (PI) Amprenavir Agenerase Indinavir sulfate Crixivan Lopinavir + ritonavir Kaletra Nelfinavir Viracept Ritonavir Norvir Saquinavir Fortovase Saquinavir mesylate Invirase Fusion inhibitors (FI) Enfuvirtide Fuzeon
Baken changed Lowis' medication from Sustiva to
Viramune a drug to relieve sleeplessness and resulting fatigue.
Most notably, the NRTI Nevirapine (
Viramune) can cause fatal hepatitis and the NRTI didanosine can cause life-threatening pancreatitis (2001).
The core drugs being compared were nelfinavir (trade name Viracept) and nevirapine (trade name
Viramune).
TMC125 (also spelled TMC-125, TMC 125, or etravirine), by Tibotec Pharmaceuticals Ltd., based in Cork, Ireland and now part of Johnson & Johnson, is a "second generation" NNRTI (non-nucleoside reverse transcriptase inhibitor)--an antiretroviral in the same class as efavirenz (brand name Sustiva, or Stochrin in many countries) or nevirapine (
Viramune).
Two applications for generic versions of
Viramune (nevirapine) tablets, one for a generic version of Retrovir (zidovudine) tablets, and one for a generic version of Sustiva (efavirenz) tablets were granted the tentative approval.
Two applications for generic versions of
Viramune (nevirapine) and one each for generic versions of Retrovir (zidovudine) and Sustiva (efavirenz) were granted the tentative approval.
* Studies begin to see increased rash in women versus men using nevirapine (
Viramune).
1996
Viramune, the first drug in the third class of antiretrovirals, is approved
Nevirapine, which manufacturer Boehringer Ingelheim markets as
Viramune, is cheaper than the more effective drugs and is sometimes provided free of charge.
