Practical methods using
boronic acid compounds for identification of class C beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli.
The [beta]-lactamases were screened for ESBL, AmpC, and carbapenemases by double disc diffusion test with discs containing clavulanic acid (4 [micro]g/mL),
boronic acid (400 [micro]g/mL) and EDTA (320 [micro]g/mL).
In other studies the modified Hodge test has been compared with other methods of detecting Amp C expression such as the
boronic acid test and EDTA disc test.
A disc diffusion assay for detection of class A, B and OXA-48 carbapenemases in Enterobacteriaceae using phenyl
boronic acid, dipicolinic acid and temocillin.
Inhibitors such as
boronic acid and dipicolinic acid inhibit class A and class B carbapenemases, respectively.
Holtsclaw, Inyang, and Singh developed treatment fluid for subterranean structures including water, a gelling agent, and a multifunctional
boronic crosslinker.
To detect the production of AmpC enzymes in Gram-negative clinical isolates resistant to cefoxitin and third generation cephalosporin (3GC) by inhibitor-based method using
boronic acid.
Because sulfonamides also inhibit the a CAs expressed in humans, other classes of small molecules have been explored such as phenols,
boronic acids, and anions [39].
Yang and Pan demonstrated an important improvement in hydrolysis of cellulose to glucose, in which a bifunctional mesoporous polymeric catalyst bearing
boronic acid as cellulose-binding groups and sulfonic acid as cellulose-hydrolytic groups was prepared, resulting in an excellent hydrolysis performance (Table 2, entry 4, Scheme 4) [229].
De Benedetto, "New evidences on efficacy of
boronic acid-based derivatization method to identify sugars in plant material by gas chromatography-mass spectrometry," Talanta, vol.
The Klebsiella pneumoniae isolate was further evaluated for the presence of carbapenemase using a phenotypic assay (Rosco, Stamford, CT, USA) containing discs of meropenem (10 [micro]g), meropenem + phenyl
boronic acid (PBA), meropenem + dipicolinic acid (DPA), and meropenem + cloxacillin (CL).
The Afinion works on the
boronic acid affinity test principle and is not affected by haemoglobin variants.
They are typically generated by the dehydration/trimerization of the respective
boronic acid, R-B[(OH).sub.2] (Bhat et al.
Screening of Hybrid Heterocyclic
Boronic Acids as Potential Anti-Cancer Agents.
