In this Review, Flemming and colleagues aim to explore the roles of microbial extracellular polymeric substances in the environment, in technology and in medicine.

In this Review, Crawford and Turocy examine diverse small molecule metabolites produced by the human microbiota, their role as potential risk factors for cancer development as well as novel mechanistic insights demonstrating their association with gastrointestinal cancer.

In this Review, Zhou, Tran et al. provide a comprehensive overview of the metabolic reactions by which microorganisms transform inorganic sulfur compounds across varied microbiomes and ecosystems, and explore the link between sulfur cycling microorganisms and climate change.

This Genome Watch discusses strategies to detect small open reading frames and study microproteins encoded in microbiomes to understand their diversity and functions across microorganisms.

This Comment highlights the challenges and rewards of researchers working in resource-limited settings, specifically Thailand, and provides potential solutions to help Thai researchers overcome these difficulties.

This study reports that bacteria protect plants against filamentous fungal infections via intercellular contacts between the bacterial cells and the conidia of the fungi.

In two recent studies, Smith, Su, Wallach et al. engineered a safer version of Bacille Calmette–Guerin with strong protection against Mycobacterium tuberculosis, while Wang, Su, Wallach, Wagner et al. developed an engineered M. tuberculosis strain as a candidate for human challenge studies.

In this study, Cross, Woolsey, Prasad et al. report obeldesivir as a promising post-exposure prophylaxis for filoviruses.

This study shows that metabolites from both an infecting pathogen and the gut microbiota of the host are major determinants of survival from bacterial sepsis in mice.