03/27/2025
research Article
While the hazards of dioxins have been well documented, the challenge of developing a comprehensive understanding of the overall health impact of dioxins remains. This paper proposes to address this challenge with a new approach methodology consisting of a novel adaptation of the Template-and-Anchor modeling paradigm.
Image credit: Kumbale et al.
Current Issue March 2025
03/20/2025
Research article
RNA 3D structure prediction often encounters entanglements, computational artifacts that complicate structural models, resulting in their exclusion from further studies despite the potentially accurate prediction of regions outside the entanglement. This study presents a protocol aimed at resolving such issues in RNA models while preserving the overall 3D fold and structural integrity
Image credit: Poblete et al
03/20/2025
research article
The authors present an integrated modelling framework of influenza transmission, immunity, and antigenic drift to show how individual-level exposure, and the build-up of population level immunity, shape the long-term epidemiological dynamics of H3N2.
Image credit: CDC
03/11/2025
research article
The authors present a method to estimate the connectivity of a network using extracellular physiological measurements. The study measured pairwise correlations between neurons in the prefrontal cortex of monkeys performing a cognitive task, and compared these values with multiple artificial neural network models trained to perform the same task as the monkeys.
Image credit: Sigalas & Libedinsky
02/18/2025
research article
This study investigates why proteins with low complexity domains are ubiquitous in liquid-like structures within cells called biomolecular condensates. The material properties of condensate are essential for cellular functions and for dictating diffusion and reaction of regulatory molecules.
Image credit: Biswas & Potoyan
02/18/2025
research article
The authors introduce a computational algorithm, termed Tumor-Immune Partitioning and Clustering, that jointly measures immune cell partitioning between tumor epithelial and stromal areas and immune cell clustering versus dispersion.
Image credit: NCI
02/14/2025
education
Research lab groups are hotspots for the education of the next generation of scientists, and making these units work as creatively as possible is essential for solving pressing issues in biology, the environment, and beyond.
Image credit: Jason Leung
01/23/2025
Education
Effective translation of AI and deep learning methods requires computational researchers to have at least a basic understanding of histopathology - this glossary aims to bridge the gap.
Image credit: Mandal et al
01/29/2025
Research Article
The authors present a quantitative approach to evaluating the role of various aspects of data in the emergence of low dimensional, topological, features.
01/24/2025
Research Article
This study explores how behavioral patterns vary across contexts and alliances.
Image credit: Hans Veth
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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