ellagic

"Carotenoids alongside resveratrol in red grapes and ellagic acids in berries offer natural sun protection to the skin.

Cherries are rich in queritrin - a flavonoid that's a potent anti-cancer agent - and ellagic acid (another potent anti-cancer agent).

Berries: Strawberries, raspberries and blackberries are high in ellagic acid, which has been shown to protect animals from esophageal cancer.

They found that pomegranate compounds (luteolin, punicic acid, and ellagic acid) significantly inhibited the growth and spread of highly invasive prostate tumors.

Aside from the obvious vitamins fruits carry, rambutan is full of ellagic acid.

The oil from a pomegranate contains the antioxidant ellagic acid which helps inhibit skin tumors, protecting the body from skin cancer.

Among the 21 coagulation assays evaluated, the following 6 tests presented a significant prolongation or activity reduction when using 3.8% buffered citrate compared to 3.2% buffered citrate: aPTT-FS (factor-sensitive reagent containing ellagic acid); [dRVVT.sub.Confirm]; [dRVVT.sub.Ratio]; and activity levels of factor V, factor VIII, and protein C (Table 2).

Rose petals of Rosa rugosa are characterized by a high content of various biologically active compounds, such as anthocyanins (glycosides, such as cyanidins, pelargonidins, and peonidins), flavonols (including derivatives of kaempferol and quercetin), flavan-3-ols, and their derivatives, procyanidins and proanthocyanidins, a large group of ellagitannins and phenolic acids, such as gallic, ellagic, quinine, and essential oils [6-8].

Ten flavonoids, galangin, kaempferol, chrysin, quercetin, myricetin, (+)-naringenin, pelargonidin chloride, pinocembrin, and rutin, as well as 11 phenolic acids, 3-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, 4-hydroxybenzoic acid, caffeic acid, vanillic acid, syringic acid, p-coumaric acid, chlorogenic acid, rosmarinic acid, ferulic acid, and ellagic acid, which were used as standards, were purchased from Sigma-Aldrich (Poznan, Poland).

These included punicalin (peak 1; retention time: 11.2 min), ellagic acid derivative (peak 2; retention time: 12.3 min), galloyl-HHDP-glucose (peak 3; retention time: 17.4 min), castalagin derivative (peaks 4 and 5; retention times: 23.6 and 26.6 min, resp.), granatin B (peak 6; retention time: 26.7 min), ellagic acid rhamnoside (peak 7; retention time: 32.2 min), kaempferol-3-O-glucoside (peak 8; retention time: 32.7 min), kaempferol derivative (peak 9; retention time: 34.9 min), and kaempferol-arabinoside (peak 10; retention time: 38.3 min).

We selected Ellagic acid as the main phytochemical based upon its rest of drug likeliness properties and hydrogen bonding with the amino acids of BCL2 target site BH3.