He held leadership roles in the successful approval of two drugs, Herceptin and
Nutropin Depot, as well as in early work on Lucentis, Avastin, and Omnitarg.
The multidose Norditropin[R] FlexPro[R] and
Nutropin AQ NuSpin[R] are prefilled and disposable.
The misbranded drugs included
nutropin, a human growth hormone, and actovegin, a substance derived from calf's blood.
About 75% switched to Norditropin, 65% to
Nutropin and Genotropin, 60% to Humatrope, 38% to Saizen, and 36% to Tev-Tropin.
Other products include Activase and TNKase (clot-busters to treat acute heart attacks and strokes), the growth hormone
Nutropin, and the pulmonary products Pulmozyme and Xolair.
Table I: Examples recent injectable drug counterfeiting cases Drug Indication Company Annual sales ($ million) Aranesp Anaemia Amgen 416 Combivir HIV GSK 882 Difl flucan Antifungal Pfi fizer 1,112 Epogen Anaemia Amgen 2,216 Levaquin Bacterial infections PSGA Neupogen Neurtopenia, Amgen 1,300 Acute myelogia
Nutropin AQ Growth hormone Genentech deficiency Procrit Anaemia PSGA 4,269 Remicade Chron's disease, RA Centocor 540 Retrov ovir HIV GSK 337 Risperdal Dementia Ortho McNeil 2,146 Serostim AIDS Serono 89 Zyprexa Schizophrenia Lilly 2,689
Our patient was started on
Nutropin AQ[R] at age 5, when his height declined to below the 3rd percentile (see Figure 1).
Examples of recent injectable drug counterfeiting cases include: Drug Indication Aranesp Anemia Combivir HIV Diflucan Antifungal Epogen Anemia Levaquin Bacterial infections Neupogen Neutropenia
Nutropin AO Procrit Anemia Remicade Chrohn's disease,/RA Retrovir HIV Risperdal Dementia Serostim AIDS Zyprexa Schizophrenia Drug Company Aranesp Amgen Combivir GSK Diflucan Pfizer Epogen Amgen Levaquin PSGA Neupogen Amgen
Nutropin AO Genentech Procrit PSGA Remicade Centocor Retrovir GSK Risperdal Ortho McNeill Serostim Serono Zyprexa Lilly Drug Annual Sales (millions) Aranesp $416 Combivir $882 Diflucan $1,112 Epogen $2,261 Levaquin Neupogen $1,300
Nutropin AO Procrit $4,269 Remicade $540 Retrovir $337 Risperdal $2,146 Serostim $89 Zyprexa $3,689