alk.

Related to alk.: ALK PHOS

alk.

abbreviation for

(Chemistry) alkali

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Lorviqua is a TKI that has been shown to be highly active in preclinical lung cancer models harboring chromosomal rearrangements of ALK. Lorviqua was specifically developed to inhibit tumor mutations that drive resistance to other ALK inhibitors and to penetrate the blood brain barrier.

European Commission Approves Lorviqua for Certain Adult Patients with Previously-Treated ALK-Positive Advanced Non-Small Cell Lung Cancer

The authors thought that the use of a more sensitive ALK antibody clone could have potentially resulted in positive staining for ALK. Although they used mouse monoclonal antibody clone 5A4 (Leica Biosystems, Buffalo Grove, Illinois), which has been validated to be highly sensitive and specific for presence of ALK rearrangements, (9,32) rabbit monoclonal antibody for ALK (clone D5F3, Ventana Medical Systems Inc, Tucson, Arizona) is reported to be more sensitive and specific for ALK rearrangements than Leica 5A4.

Epithelioid inflammatory myofibroblastic sarcoma: an aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK. Am J Surg Pathol.

Inflammatory Myofibroblastic Tumor in Female Genital Tract

(d) Fluorescence in situ immune-hybridization signals of ALK. Split red and green signals can be observed.

ALK-Positive Squamous Cell Carcinoma Dramatically Responded to Alectinib

About 5% of NSCLC patients have been found to have a rearrangement in a gene called ALK. This change is most often seen in non-smokers (or light smokers) who have the adenocarcinoma subtype of NSCLC.

Ventana seeks FDA premarket approval for ALK IHC companion diagnostic to benefit lung cancer patients

According to the company, it will dose patients with ALK+ non-small cell lung cancer (NSCLC) who have not been previously treated with ALK inhibitors, NSCLC who have progressed during treatment with other ALK inhibitors and those with other tumor types expressing ALK.

TESARO Inc to proceed with Phase 1/2 clinical study of TSR-011 upon acceptance of IND

This discrepancy between a low percentage of visible ALK FISH-positive cancer cells and homogeneous ALK expression can be explained by the fact that EML4 is only 12 megabases apart from ALK. Therefore, the intrachromosomal inversion leads to only a small separation distance between the red and the green signal.

Common Fluorescence In Situ Hybridization Applications in Cytology

Detection of ALK-positive NSCLC is necessary for selection of patients for treatment with Pfizer's crizotinib, an investigational oral first-in-class agent that inhibits ALK.

Pfizer gets patent licence on EML4-ALK from Cell Signaling Technology

Crizotinib and testing for ALK. J Natl Compr Canc Netw.

Precision medicine for lung cancer: role of the surgical pathologist

Farnham, Surrey; ISBN 9780199832606 (pbk.; alk. paper).

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(170) However, there is evidence that ALK may be indirectly activated by pleiotrophin via inhibition of receptor protein tyrosine phosphatase ([beta]/[zeta] rather than by direct ligand binding to ALK. (175)