Wahid Haq

American International University-Bangladesh, Accounting and Finance, Graduate Student

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Papers by Wahid Haq

Folk Medicinal Use of Plants to Treat Skin Disorders in Chandpur District, Bangladesh

American Journal of Ethnomedicine, 2017

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A Survey of Medicinal Plants Used by Folk Medicinal Practitioners of Paschim Shawra and Palordi Villages of Gaurnadi Upazila in Barisal District, Bangladesh

American-Eurasian Journal of Sustainable Agriculture, 2011

ABSTRACT Folk medicinal practitioners (Kavirajes) are possibly the most ancient practitioners of ... more ABSTRACT Folk medicinal practitioners (Kavirajes) are possibly the most ancient practitioners of traditional medicine in Bangladesh and in general are the primary health-care providers to a majority of the rural population and a substantial segment of the urban population in the country. The Kavirajes rely almost exclusively on medicinal plants for treatment of various ailments. The medicinal plants chosen by the Kavirajes vary considerably even between adjacent villages. To get a comprehensive view of folk medicinal practices, it is therefore important to survey as many Kavirajes of different villages as possible. The objective of the present study was to conduct an ethnomedicinal survey among the Kavirajes of Paschim Shawra and Palordi villages, Gaurnadi Upazila, Barisal district, which lies in the southern section of the country. Informed consent was obtained of the Kavirajes and interviews conducted with the help of a semi-structured questionnaire and the guided field-walk method. All plant specimens as pointed out by the Kavirajes were collected and brought back for identification at the Bangladesh National Herbarium. It was observed that the Kavirajes of Paschim Shawra and Palordi villages used 51 plants distributed into 33 families for treatment of various ailments. The Fabaceae family contribued the higest number of species (6 plants) followed by the Lamiaceae (4 plants), Lythraceae and Zingiberaceae families (3 plants per family). Leaves constituted the major plant part used (43%), followed by whole plant(12%), rhizome (6%), bark (4%).The largest number of remedies was used to treat gastrointestinal disorders (23 plants), suggesting that this is the most prevalent disorder in the area. Respiratory tract disorder (11 plants) like coughs, chest pain, bronchitis, asthma and whooping cough and sexual disorders (11 plants) including leucorrhea, sexual weakness, menstrual problem, gonorrhea and loss of libido formed the second most common disorders treated by the Kavirajes. 10 plants were used for the treatment of skin diseases like tinia infection, scabies, and eczema. The Kavirajes also used medicinal plants for treatment of ailments including diabetes, urogenital disorder, hepatic disorder, neurological disorder, pain and inflammation, fever, weakness, infectious, cancer, blood purifier, blood clotting agent, anemia, snake bite, insect bite ,aging, appetizer, blood pressure, malaria, heart disease and others. A perusal of the scientific literature showed that uses of several plants by the Kavirajes are validated by scientific studies on the pharmacological activities of the relevant plant species. Overall, the plants present considerable potential for further scientific studies leading to discovery of novel drugs.

The book review: European Association of Science Editors Science Editors' Handbook (2nd edition)

Science Editing, Aug 18, 2014

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Abstract 6118: Tumor-derived GDF-15 promotes immune escape of tumors by functional alteration of the myeloid compartment

Cancer Research

Background: Growth and differentiation factor 15 (GDF-15), a divergent member of the TGF-β protei... more Background: Growth and differentiation factor 15 (GDF-15), a divergent member of the TGF-β protein superfamily, shows low physiological baseline expression. GDF-15 is, however, strongly upregulated during pregnancy. It is further induced in stressed and damaged tissues, where it limits immune infiltration and inflammation. In solid tumors, GDF-15 was shown to be a key inhibitor of T-cell infiltration. While this might already explain the strong correlation between GDF-15 overexpression and poor survival with or without checkpoint-based immunotherapy, effects of GDF-15 on dendritic cells and monocytes may further shape the tumor microenvironment. Methods: To analyze the impact of GDF-15 in murine tumor models, GDF-15 was either deleted by CRISPR/CAS9 gene editing or neutralized by administration of a blocking antibody. Effects on tumor growth were recorded and the composition of the tumor microenvironment was characterized by flow cytometry. More detailed insight into tumor-immune in...

A Survey of Medicinal Plants Used by Folk Medicinal Practitioners in Daulatpur Upazila of Kushtia District, Bangladesh

Planta, 2021

The present paper focused on medicinal plants used by traditional practitioners in Daulatpur Upaz... more The present paper focused on medicinal plants used by traditional practitioners in Daulatpur Upazila of Kushtia district, Bangladesh from October 2018 to September 2019. The information about medicinal plants uses of traditional practitioners was collected through interview. A total of 45 medicinal plant species under 43 genera and 33 families have been documented which are used for the treatment of 48 categories diseases. These medicinal plants are used by the traditional practitioners for the treatment of various diseases like asthma, anemia, burning sensation, blood pressure, constipation, cough, diarrhea, diabetes, dysentery, eczema, fever, headache, heart disease, jaundice, leprosy, toothache, ulcer, skin disease, snake-bite, wound, and others. All these plants need to be evaluated through phyto and pharmaco-chemical investigations to discover their potentiality and may help in discovering effective drugs for human health care.

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Folk Medicinal Use of Plants to Treat Skin Disorders in Chandpur District, Bangladesh

American Journal of Ethnomedicine, 2017

Title: Folk medicinal use of plants to treat skin disorders in Chandpur district, Bangladesh. Bac... more Title: Folk medicinal use of plants to treat skin disorders in Chandpur district, Bangladesh. Background: Folk medicinal practitioners (FMPs) possibly form the largest group of traditional medicinal practitioners in Bangladesh. FMPs essentially use plants for treatment of diseases; however, the selection of plants can differ widely among FMPs even within the same region. The objective of the present study was to document the phytotherapeutic practices of several FMPs in Chandpur district, who treated various types of skin disorders. Methods and findings: Interviews of the FMPs regarding their phytotherapeutic practices were carried out with the help of a semi-structured questionnaire and the guided field-walk method between 2016-2017. The FMPs used a total of 10 plants distributed into 10 families in their 9 formulations. Conclusions: Skin diseases are common in Bangladesh, particularly among the rural and urban slum people. These people most often cannot afford a visit to allopathic doctors. As such, the medicinal plants of the FMPs can prove useful in the treatment of skin disorders.

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Hypoglycemic and Antinociceptive Effects of Saraca asoca (Roxb.) De Wilde Bark Extract in Swiss Albino Mice

Phytoremediation and Prospects of Cleaning up a Tannery Waste Contaminated Site in Dhaka, Bangladesh

ABSTRACT Hazaribagh is an area within Dhaka city, the capital of Bangladesh. Thousands of skins o... more ABSTRACT Hazaribagh is an area within Dhaka city, the capital of Bangladesh. Thousands of skins of animals like cows, goats, lambs, and buffaloes are processed at this site on a daily basis, the meat of these animals being used to serve the needs of around 16 million people of Dhaka. Since proper treatment of wastes are not conducted at the site, the soil of the area and surrounding water bodies like a canal and the Rivers Buriganga and Turag have been heavily contaminated with tannery waste toxic products. It was of interest to find out the plants growing on the contaminated site and water bodies, and determine through perusal of published literature as to whether these plants have phytoremediation potential, for then these plants can offer a cheap and viable alternative to clean up the waste site. A total of 21 plants distributed into 19 families were observed to be growing at the contaminated area and surrounding water bodies. A search of the scientific literature showed that most of these plants have reported phytoremediation potentials. It is concluded that these plants can form an alternative towards removing tannery wastes from the contaminated area(s), which removal can provide health benefits to the people residing in the area.

Differences in selection of medicinal plants between folk and tribal medicine: a case study of a Santal tribal and a non-Santal folk medicinal practitioner in two adjoining districts of Bangladesh

Bangladesh has a number of traditional medicinal systems among which folk medicinal practitioners... more Bangladesh has a number of traditional medicinal systems among which folk medicinal practitioners constitute the majority and who can be found practicing in virtually every village, town and city of the country. Bangladesh also has over a hundred different tribes scattered throughout the country, who have their own tribal medicinal practitioners. Some of these tribes have maintained their unique cultural traditions, while others are in various stages of assimilation with the mainstream Bengali-speaking population. The common feature between folk medicinal and tribal medicinal practitioners is that both groups rely on medicinal plants as the major ingredient in their medicinal formulations. The Santals are one of the largest tribes in northwestern districts of Bangladesh. While some Santal communities reside in their separate villages apart from the villages of the mainstream population, other Santal communities can be found living among the mainstream population. It was of interest to determine whether such close proximity of living between Santal and non-Santal people have led to mutual exchanges of medicinal information regarding choice of medicinal plants for treatment of common ailments. An ethnomedicinal survey was therefore carried out among a Santal practitioner of Dabidubi village in Dinajpur district, and a mainstream folk medicinal practitioner of Goreya Bazaar village in Thakurgaon district, the two villages being in close proximity. It is to be noted that both villages were inhabited by a heterogeneous population consisting of both people from the Santal tribe as well as mainstream Bengali-speaking people. Altogether 76 formulations were obtained from the two healers, the Santal healer providing 44 formulations and the mainstream folk healer providing 32 formulations. Both healers used medicinal plants as the chief ingredient in their formulations. The Santal healer used a total of 50 plant species in his formulations, while the non-Santal healer used a total of 44 plant species in his formulations. Surprisingly, although many ailments treated by the two healers were in common, the formulation used by the Santal healer differed totally from the non-Santal mainstream healer, even though all plant species used by the two healers could be found in both the villages of their residences. Only one plant species, namely Aegle marmelos, was used in common by both healers as a stomachic and for the treatment of dysentery, but even then the formulations were different. A second plant species, Syzygium cumini, used in common by both healers, were used for treatment of different ailments. The same applied to two other plant species, Nigella sativa and Piper nigrum, which though commonly used by the healers were used in different types of formulations for treatment of different diseases. The results not only suggest that the Santals have their own unique repertoire of medicinal plants but also suggests that despite centuries of living in close proximity to each other, tribal medicinal practitioners and mainstream folk medicinal practitioners have evolved their medicinal plant selections separately and which are clearly distinguishable from each other. The results further highlight the study of traditional healers among all communities and villages of Bangladesh to obtain a comprehensive account of the various medicinal plants used and their purpose of use.

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The book review: European Association of Science Editors Science Editors' Handbook (2nd edition)

Science Editing, 2014

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Anti-inflammatory effect of Curcuma longa (turmeric) rhizome when administered topically in gel form

Planta Medica, 2009

ABSTRACT Curcuma longa L. (Zingiberaceae) rhizome (turmeric) is widely used in folk medicine of t... more ABSTRACT Curcuma longa L. (Zingiberaceae) rhizome (turmeric) is widely used in folk medicine of the Indian subcontinent for inflamed joints. The objective of the present study was to investigate the anti-inflammatory effects of turmeric when administered topically in gel form to carrageenan-induced paw edema in rats. Gels contained polyethylene glycol-6000, sodium carboxymethyl cellulose and isopropyl alcohol without and with turmeric powder or diclofenac. The right hind paw of all rats were pre-treated twice daily for 2 days with gel without (Group 1) or containing turmeric powder at 3.33, 10 and 33.3% w/v (Groups 2, 3 and 4, respectively). Group 5 rats were pre-treated with gel containing the standard anti-inflammatory drug diclofenac (1% w/v). Edema was induced on Day 3 by injecting 0.1ml of 1% carageenan solution (in normal saline) into the plantar surface of the right hind paw of each rat. Increase in paw volume was monitored up to 5 hours after injection. Significance levels of the results were calculated using Student&#39;s t-test and date were considered statistically significant when P&lt;0.05. Pre-treatment with turmeric-containing gel produced a significant and dose-dependent inhibition of rat paw edema. Compared to controls, at the highest dose (33.3% turmeric), edema was inhibited by 53.4±2.6, 40.0±3.3, 36.3±2.8, 33.5±3.7 and 31.4±3.4%, respectively, at the first, second, third, fourth and fifth hour following carrageenan injection. These results compare favorably with diclofenac, where the respective inhibitions were 35.5±3.4, 36.5±3.3, 33.5±3.7, 29.5±3.0 and 24.5±4.0%. Even at the lowest dose (3.33%), turmeric inhibited paw edema by 27.4% at the first hour following carrageenan injection. The results validate the folk medicinal use of turmeric as an anti-inflammatory agent.

A diagnostically relevant epitope of A. fumigatus

Journal of Allergy and Clinical Immunology, 2003

RATIONALE: To detect and quantify environmental allergens such as moulds by ELISA, large quantiti... more RATIONALE: To detect and quantify environmental allergens such as moulds by ELISA, large quantities of monoclonal antibodies (Mabs) are required. OBJECTIVE: The aim of the study was to determine if rabbit polyclonal antibodies (Pabs) to cloned AIt al could be appropriate to develop ELISA kits for aeroallergens. Comparison of the specificity and affinity of a) mouse Mabs to cloned versus native Alt al and b) rabbit Pabs versus mouse Mabs to cloned Alt al was carried out. METHODS: Native Alt al was purified from Alternaria alternata using chromatography techniques. Cloned Alt al was prepared by immunoscreening of cDNA library. Rabbit antisera were prepared against native and cloned Alt al and purified. Mouse Mabs to cloned and native Alt al were produced in Balb/c mice. Specificity and affinity of Pabs and Mabs were examined by ELISA. Cross-reactivity of the antibodies was examined against Aspergillus, Cladosporium, Stachybotrys, and Penicillium species by ELISA. RESULTS: The Mabs to cloned Alt al were significantly stronger than those for native Alt al by ELISA and Immunoblot. The Pabs against cloned Alt al were found to be specific in quantifying the allergen in an unknown A. alternata extract and correlated significantly (r=0.90) with Mabs. The Pabs and Mabs to cloned Alt al were found to be non-reactive to the moulds tested above, CONCLUSION: Polyclonal antibodies against cloned Alt al can be used to quantify this allergen. Purified polyclonal versus monoclonal antibodies can be obtained in large quantities.

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Review: The Prime of Miss Jean Brodie

Film Quarterly, 1969

Paradigm for Total Quality Management in Building Maintenance Operation

eprints.covenantuniversity.edu.ng

PARADIGM FOR TOTAL QUALITY MANAGEMENT IN BUILDING MAINTENANCE OPERATION. AMUSAN LEKAN M. BUILDING... more

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An ethnomedicinal survey of cucurbitaceae family plants used in the folk medicinal practices of Bangladesh1

Chronicles of Young Scientists, 2012

ABSTRACT Background: The Cucurbitaceae family comprising about 125 genera and 960 species is a fa... more ABSTRACT Background: The Cucurbitaceae family comprising about 125 genera and 960 species is a family that is further characterized by commonly having five-angled stems and coiled tendrils and is also known as gourd family of flowering plants. Plant species belonging to this family have a worldwide distribution, but most species can be found in tropical and subtropical countries. A number of the plants belonging to this family have reported important pharmacological activities. Cucurbitaceae family plants are also in use in the folk medicinal system of Bangladesh-a traditional medicinal system, which mainly relies on medicinal plants for treatment of diverse ailments. Aims: Since folk medicinal practitioners form the first tier of primary health care in Bangladesh, the objective of this study was to conduct ethnomedicinal surveys among 75 folk medicinal practitioners (Kavirajes) practicing among the mainstream Bengali-speaking population of randomly selected 75 villages in 64 districts of Bangladesh and 8 tribal practitioners (1 each from 8 major indigenous communities or tribes, namely, Bede, Chakma, Garo, Khasia, Marma, Murong, Santal, and Tripura) of the country. Materials and Methods: Surveys were carried out with the help of a semi-structured questionnaire and the guided field-walk method. Results: It was observed that the folk and tribal medicinal practitioners use a total of 19 Cucurbitaceae family species for treatment of ailments such as dysentery, diabetes, edema, skin disorders, leukoderma, hypertension, jaundice, typhoid, spleen disorders, respiratory problems, leprosy, rheumatoid arthritis, chicken pox, and cancer. The 19 species of Cucurbitaceae family plants in use were Benincasa hispida, Bryonopsis laciniosa, Citrullus colocynthis, Citrullus lanatu, Coccinia grandis, Cucumis melo, Cucumis sativus, Cucurbita maxima, Cucurbita pepo, Hodgsonia macrocarpa, Lagenaria vulgaris, Luffa acutangula, Luffa cylindrica, Momordica charantia, Momordica cochinchinensis, Trichosanthes anguina, Trichosanthes cordata, Trichosanthes dioica, and Trichosanthes kirilowii. The review of the available scientific literature showed that the use of a number of the above-mentioned plants in folk medicine can be validated based on their reported pharmacological activity studies. Conclusion: Taken together, the plants present excellent potential for further scientific studies, which may result in discovery of novel compounds of therapeutic interest.

Ethnomedicinal plants of folk medicinal practitioners in four villages of Natore and Rajshahi districts, Bangladesh

An ethnomedicinal survey was carried out among folk medicinal practitioners of four villages in N... more An ethnomedicinal survey was carried out among folk medicinal practitioners of four villages in Natore and Rajshahi districts of Bangladesh. The four folk medicinal practitioners interviewed were observed to use a total of 89 plants in their different formulations. These plant species were distributed into 48 families. The practitioners treated a diverse variety of ailments including skin disorders, respiratory tract disorders, ear infections, gastrointestinal disorders, hypertension, sexual problems, menorrhagia, pain, eye problems, diabetes, osteoporosis, arthritis, sexually transmitted diseases, urinary problems, fever, paralysis, cuts and wounds, chicken pox, weakness, kidney problems, jaundice, broken bones, and hepatitis B. Plants were also used as moisturizer, for relaxing uterine muscle, for treatment of snake bite, and as snake repellent. By far, from the number of plants used, the major problems of the village communities surveyed appeared to be skin disorders, respiratory tract disorders, gastrointestinal disorders, sexual problems, pain, and diabetes. Seven plants were used for treatment of diabetes. Plants used for treatment of diabetes (Stevia rebaudiana, Cycas pectinata, Diospyros ebenum, Cinnamomum tamala, Asparagus racemosus, Tinospora cordifolia, and Corchorus aestuans) are particularly interesting for further pharmacological studies, for diabetes is a debilitating disease affecting millions of persons throughout the world, and cannot be cured with allopathic medicine. As such, any drugs that can be discovered from the anti-diabetic plants obtained in the present survey can possibly alleviate the sufferings of millions of diabetic patients and can be really beneficial for human beings. The plants used for treatment of osteoporosis, hepatitis B, and arthritis are also interesting for further studies. These plants can provide a cheaper alternative to the existing allopathic drugs and which may be more affordable to the rural people of Bangladesh, who lack both access to modern clinics as well as cannot afford the prices of allopathic drugs.

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Antihyperglycemic and antinociceptive activity evaluation of methanolic extract of whole plant of Amaranthus Tricolor L. (Amaranthaceae)

African Journal of Traditional, Complementary and Alternative Medicines, 2013

Amaranthus tricolor whole plants are used by folk medicinal practitioners of Bangladesh for treat... more Amaranthus tricolor whole plants are used by folk medicinal practitioners of Bangladesh for treatment of pain, anaemia, dysentery, skin diseases, diabetes, and as a blood purifier. Thus far, no scientific studies have evaluated the antihyperglycaemic and antinociceptive effects of the plant. The present study was carried out to evaluate the possible glucose tolerance efficacy of methanolic extracts of A. tricolour whole plants using glucose-induced hyperglycaemic mice, and antinociceptive effects with acetic acid-induced gastric pain models in mice. In antihyperglycaemic activity tests, the extract at different doses was administered one hour prior to glucose administration and blood glucose level was measured after two hours of glucose administration (p.o.) using glucose oxidase method. The statistical data indicated the significant oral hypoglycaemic activity on glucose-loaded mice at all doses of the extracts tested. Maximum antihyperglycaemic activity was shown at 400 mg extract per kg body weight, which was comparable to that of a standard drug, glibenclamide (10 mg/kg body weight). In antinociceptive activity tests, the extract also demonstrated a dose-dependent significant reduction in the number of writhings induced in mice through intraperitoneal administration of acetic acid. Maximum antinociceptive activity was observed at a dose of 400 mg extract per kg body weight, which compared favourably with that of a standard antinociceptive drug, aspirin, when administered at a dose of 200 mg per kg body weight. The results validate the folk medicinal use of the plant for reduction of blood sugar in diabetic patients as well as the folk medicinal use for alleviation of pain. The results suggest that this plant may possess further potential for scientific studies leading to possible discovery of efficacious antihyperglycaemic and antinociceptive components.

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Medicinal plants used by folk medicinal practitioners of six villages in Thakurgaon district, Bangladesh