... Sadece lise öğrencilerinin değerlendirildiği grubumuzda akne başlangıç yaş ortalamasının kızl... more ... Sadece lise öğrencilerinin değerlendirildiği grubumuzda akne başlangıç yaş ortalamasının kızlarda (13,4±1,3) erkeklerdekinden (14,1±1,1) daha küçük olduğu görüldü (p<0.001). ... Şebnem Aktan, Işıl İnanır, Berna Şanlı, Nuran Uz. ...
ranuloma faciale (GF) is an uncommon chronic and inflammatory dermatosis accepted as a localized ... more ranuloma faciale (GF) is an uncommon chronic and inflammatory dermatosis accepted as a localized form of smallvessel vasculitis with frequent leukocytoclasis. 3,4 Clinically it is characterized by single or multiple asymptomatic, reddish brown to violaceous papules, nodules, and plaques typically localized on the face. The sites of predilection are the sides and tip of the nose, the preauricular area, the cheeks, the forehead, and the helix of the ear. 1,3-7 The condition most commonly occurs in middle-aged, white men, 1,3-7 and is limited to the skin, without any systemic manifestations. The course is generally chronic and asymptomatic with frequent resistance to the therapy. Extrafacial lesions of GF are rather infrequent. 3-11 The facial lesions usually precede extrafacial lesions, which may present months to several years after the appearance of facial disease. Occasionally, extrafacial lesions may appear simultaneously or exceptionally they may occur alone. 8,9 Researchers have suggested that factors such as actinic exposure or a localized Arthus-like response might play a pivotal role in triggering the lesions. 3,4,12 Some
Wound healing is actually a complex, precisely coordinated interaction between inflammatory cells... more Wound healing is actually a complex, precisely coordinated interaction between inflammatory cells and mediators, establishing significant overlap between the phases of wound healing. Chronic wounds are defined as wounds that do not follow the well-defined stepwise process of physiologic healing. The true incidence and economic impact of chronic wounds are difficult to assess because of the wide range of causative diseases and available treatment options. Despite multiple simultaneous and sequential therapeutic approaches, chronic wounds are highly resistant to treatment and are often indolent or even slowly progressive. Hyperbaric oxygen therapy (HBOT) has been explored as a treatment modality for chronic wounds because of its potential to promote healing and reduce bioburden in the wound bed. Multiple potential beneficial effects for wound healing have been demonstrated in various laboratory studies and experimental animal models. In this manuscript, HBOT, its mechanism of action, adverse effects and usage in diabetic and nondiabetic chronic wounds have been reviewed.
ABSTRACT Keratinocyte damage and lichenoid-interface reaction are the two major pathologic findin... more ABSTRACT Keratinocyte damage and lichenoid-interface reaction are the two major pathologic findings in lichen planus (LP). Matrix metalloproteinases (MMPs) are proteinases that participate in extracellular matrix (ECM) degradation and may play an important role in basal membrane (BM) damage in LP. Fibronectin (FN) mediates a variety of cellular interactions with ECM and plays important roles in cell adhesion, migration, growth and differentiation. To determine MMP-2, MMP-3, MMP-9 and FN expressions in LP and discuss the possible associations. Skin biopsy samples of 55 patients with LP and 11 normal skin were investigated. Five discoid lupus erythematosus (DLE) and 5 chronic dermatitis (CD) samples were also examined for comparison. Immunochemical stainings were performed for MMP-2, MMP-3, MMP-9 and fibronectin. Weak or absent expressions of MMP-2 and MMP-3 in epidermis; and dense MMP-9 expression in dermal inflammatory infiltrate cells were detected in LP. FN expression was lost in epidermal basal layer and papillary dermis. Loss of MMP-2, MMP-3 and FN in LP can be explained with the destruction of the epidermal basal layer. Similar expressions of MMP-2 and MMP-3 both in LP and DLE implied that these MMPs may be involved in the pathogenesis of interface dermatitis.
Background: Psoriasis is a common chronic inflammatory disease. Having more information about pso... more Background: Psoriasis is a common chronic inflammatory disease. Having more information about psoriasis and comorbid diseases means that patients have more involvement in treatment. Aim: Evaluate the knowledge levels of psoriasis patients about the disease and comorbidities and also to determine participation in treatment decisions. Methods : Totally 103 patients over the age of 18 with diagnosed psoriasis were included into the study. A questionnaire including items on knowledge about disease and treatment options, comorbid diseases were filled out by the patients. Total knowledge score (TKS) was found by giving 1 point to the questions that the patients knew correctly. Results: Patients were well informed about their risk of depression (64.1%), but were less well informed about their risk of atherothrombotic disease (14.6%). %50.4 of the patients thought that psoriasis may be due to an internal organ disease. There was a negative correlation between the patient's age, the age of diagnosis and TKS. 42.7% wanted to leave the decision entirely to the physician. Conclusion: The results of this study showed that majority of patients with psoriasis are not aware of the increased risk of comorbid diseases and do not have enough knowledge about psoriasis.
Melanositik pigmente deri lezyonlarýnýn birbirinden ayýrýmý, planlanacak tedavi yaklaþýmý açýsýnd... more Melanositik pigmente deri lezyonlarýnýn birbirinden ayýrýmý, planlanacak tedavi yaklaþýmý açýsýndan önemlidir. Bu amaçla yapýlacak histopatolojik incelemeye alternatif olarak son zamanlarda preoperatif tanýsal doðruluðu belirgin arttýran dermoskopi yöntemi olarak ön plana çýkmýþtýr. Bu çalýþmada, sýkça karþýlaþtýðýmýz melanositik pigmente lezyonlardan olan nevus nevosellularislerde dermoskopinin histopatolojik incelemenin yerine geçip, geçemeyeceði araþtýrýlmýþtýr. Çalýþmamýzda, Eylül 1998-Haziran 1999 tarihleri arasýnda Celal Bayar Üniversitesi Týp Fakültesi Dermatoloji Anabilim Dalý Ben Takip Polikliniði' ne baþvuran 22 hastadaki toplam 25 nevus nevosellularis dermoskopik olarak incelendikten sonra alýnan biyopsi materyallerinin histopatolojik tetkiki yapýlmýþ ve her iki yöntemle konulan tanýlar karþýlaþtýrýlmýþtýr. Dermoskopik muayenede el dermatoskopu, slayt çekimlerinde Dermaphot kullanýlmýþtýr. Dermatoskopi ve histopatoloji yöntemlerinin tutarlýlýðýný ölçmek için Kappa analizi yapýlmýþtýr. Dermoskopik olarak 7 jonksiyonel nevus naevocellularis (NNC), 15 bileþik NNC, 3 intradermal NNC tanýsý konulurken, histopatolojik olarak 7 jonksiyonel NNC, 10 bileþik NNC, 8 intradermal NNC tanýsý konulmuþtur. Dermoskopik olarak 25 lezyonun 20'si (%80), histopatolojik tanýyla ayný tanýyý almýþtýr. Kappa istatistiðinde iki yöntemle konulan tanýlarýn iyi derecede tutarlý olduðu bulunmuþtur (K= 0.69). Noninvaziv taný yöntemi olarak son yýllarda ön plana çýkan dermoskopinin melanositik pigmente deri lezyonlarýndan nevus nevosellularislerin tanýsýnda ve ayrýmýnda histopatolojik incelemenin yerine geçemeyeceði sonucuna varýlmýþtýr. Dermoskopi, Melanositik pigmente deri lezyonlarý, Nevus nevosellularis, Histopatolojik inceleme.
Melanositik pigmente deri lezyonlarının birbirinden ayırımı, planlanacak tedavi yaklaşımı açısınd... more Melanositik pigmente deri lezyonlarının birbirinden ayırımı, planlanacak tedavi yaklaşımı açısından önemlidir. Bu amaçla yapılacak histopatolojik incelemeye alternatif olarak son zamanlarda preoperatif tanısal doğruluğu belirgin arttıran dermoskopi yöntemi olarak ön ...
Işıl Inanır primarily performed the diagnosis, treatment, and follow-up of the patient. Peyker Te... more Işıl Inanır primarily performed the diagnosis, treatment, and follow-up of the patient. Peyker Temiz performed the histopathological examination. Fatmagül Gülbaşaran drafted the manuscript, Kamer Gündüz revised it, and all other authors contributed revisions and approved the final manuscript.
Objective: It has been a debate whether phenotypic features are associated with increased risk of... more Objective: It has been a debate whether phenotypic features are associated with increased risk of coronary heart disease. Proposed explanations for this relation include biological aging, individual susceptibilities, and androgens which contribute to both the atherosclerotic process and dermatological signs. The results of the studies are inconsistent and most are not based on cardiovascular imaging techniques. Here, association between androphenotypic features and the risk and severity of coronary artery disease (CAD) in men is evaluated. Methods: This case–control study consists of 166 male patients with angiography-proven CAD and 160 age-gender-matched controls. Gensini score of angiograms (for severity of CAD) and phenotypic characteristics including androgenetic alopecia (AGA), thoracic hairiness (TH), hair graying a diagonal earlobe crease (DEC), and hairy ear (HE) were recorded. Men with well-established cardiovascular risk factors were excluded. Results: AGA, DEC, and HE were significantly more frequent in patients with CAD than controls (98.2% and 83.1% [P < 0.001], 61.4% and 23.8% [P < 0.001], 69.3% and 50.6% [P = 0.001], respectively). As the severity of AGA increased, the incidence of heart disease was increasing in patients. The presence of TH and AGA was found to be related to higher Gensini scores. Conclusion: The exact mechanism between these phenotypic features and CAD still remains to be elucidated. However, observation of visible aging signs is easy and inexpensive. AGA, HE, and DEC may be used as early screening tools for CAD.
Amaç: Layşmanyazın laboratuvar tanısı, kültür, mikroskopik inceleme, serolojik ve moleküler yönte... more Amaç: Layşmanyazın laboratuvar tanısı, kültür, mikroskopik inceleme, serolojik ve moleküler yöntemlere dayanır. Tüm dünyada kültür için sıklıkla Novy-MacNeal-Nicolle (NNN) besiyeri kullanılmaktadır. Moleküler tanı yöntemlerinin tanısal amaçlı kullanımı sonrası NNN besiyerinin duyarlılığı konusunda şüpheler oluşmuştur. Bu çalışmada, yeni bir besiyerinin etkinliğinin NNN besiyeri ve moleküler yöntemle karşılaştırılması amaçlanmıştır. Yöntemler: Manisa Celal Bayar Üniversitesi Tıp Fakültesi Tıbbi Parazitoloji Anabilim Dalı'na Kilis, Osmaniye, Bitlis, Gaziantep ve Manisa illerimizdeki sağlık merkezlerinden tanı veya doğrulama amacıyla kutanöz layşmanyaz (KL) şüpheli 22 ve viseral layşmanyaz (VL) şüpheli 4 hasta örneği gönderilmiştir. Bu illerdeki sağlık merkezlerine önceden hazırlanan besiyerleri gönderilmiş ve alınan klinik örneklerden bu besiyerlerine ekim yapılması istenmiştir. KL için alınan iğne aspirasyon sıvısı ve VL için kemik iliği örnekleri, NNN besiyerine ve yeni geliştirilen karaciğer ekstreli besiyerlerine eşzamanlı olarak ekilmiş, yayma preparatlarıyla birlikte kurumumuza gönderilmiştir. Yayma preparatları Giemsa yöntemiyle boyanarak incelenmiştir. Ayrıca bu materyallerde gerçek zamanlı polimeraz zincir reaksiyonu yöntemiyle parazit DNA'sı aranmıştır. Bulgular: 26 örneğin 14'ünde Leishmania amastigotları görülmüştür. Örneklerden NNN besiyerine ekilenlerin 8'inde, yeni besiyerine ekilenlerin ise 24'ünde promastigot üremesi görülmüştür. KL şüpheli 2 hastada her iki besiyerinde de parazit üretilememiştir. Genotiplendirme yapıldığında dermotropik yerleşim gösteren izolatların L. tropica, L. major ve L. infantum/donovani; viserotropik yerleşim gösteren izolatların ise L. tropica ve L. infantum/donovani olduğu saptanmıştır.
OBJECTIVES Leishmaniasis is a vector-borne disease and dogs may act as urban reservoirs. Turkey a... more OBJECTIVES Leishmaniasis is a vector-borne disease and dogs may act as urban reservoirs. Turkey and most of the Mediterranean basin countries are endemic for leishmaniasis. In this study, it is aimed to report the autochthonous leishmaniasis cases, with all the components of the infection cycle (reservoir, vector, and the host) in a region close to Europe. METHODS Nine human and four canine autochthonous leishmaniasis cases were included in the study. Direct microscopy, culture methods, serological, and molecular tests were applied to the samples obtained from the cases. RESULTS VL and CL patients consisted of 2 L.infantum, 1 L. donovani, 2 L. tropica, and 2 L. tropica,1 L. major,1 L. infantum infected patients respectively. CanL cases were infected with L. infantum, L. donovani, L. tropica, and L. major. CONCLUSIONS All the cases were autochthonous cases located in Manisa province. As Greece and all the Mediterranean basin countries in Europe share competent vectors, it is concluded that the detection of all 4 species of Leishmania parasites in such proximity to Europe poses an important public health threat for Europe. This study reports all four species of Leishmania spp., including L. major and L.donovani in close proximity to continental Europe.
We describe a 48-year-old woman with three erythematous nodules localized on the left forearm, wi... more We describe a 48-year-old woman with three erythematous nodules localized on the left forearm, with 2 months evolution. Histological and immunohistochemical examination revealed a CD30(+) large-cell lymphoma. Systemic involvement was not detected. The tumor regressed spontaneously within a week, after the incisional skin biopsy. In control skin biopsy, there was not any histological feature of lymphoma. No reactivation or any symptom of systemic disease was observed during the 10-month follow-up period.
... Sadece lise öğrencilerinin değerlendirildiği grubumuzda akne başlangıç yaş ortalamasının kızl... more ... Sadece lise öğrencilerinin değerlendirildiği grubumuzda akne başlangıç yaş ortalamasının kızlarda (13,4±1,3) erkeklerdekinden (14,1±1,1) daha küçük olduğu görüldü (p<0.001). ... Şebnem Aktan, Işıl İnanır, Berna Şanlı, Nuran Uz. ...
ranuloma faciale (GF) is an uncommon chronic and inflammatory dermatosis accepted as a localized ... more ranuloma faciale (GF) is an uncommon chronic and inflammatory dermatosis accepted as a localized form of smallvessel vasculitis with frequent leukocytoclasis. 3,4 Clinically it is characterized by single or multiple asymptomatic, reddish brown to violaceous papules, nodules, and plaques typically localized on the face. The sites of predilection are the sides and tip of the nose, the preauricular area, the cheeks, the forehead, and the helix of the ear. 1,3-7 The condition most commonly occurs in middle-aged, white men, 1,3-7 and is limited to the skin, without any systemic manifestations. The course is generally chronic and asymptomatic with frequent resistance to the therapy. Extrafacial lesions of GF are rather infrequent. 3-11 The facial lesions usually precede extrafacial lesions, which may present months to several years after the appearance of facial disease. Occasionally, extrafacial lesions may appear simultaneously or exceptionally they may occur alone. 8,9 Researchers have suggested that factors such as actinic exposure or a localized Arthus-like response might play a pivotal role in triggering the lesions. 3,4,12 Some
Wound healing is actually a complex, precisely coordinated interaction between inflammatory cells... more Wound healing is actually a complex, precisely coordinated interaction between inflammatory cells and mediators, establishing significant overlap between the phases of wound healing. Chronic wounds are defined as wounds that do not follow the well-defined stepwise process of physiologic healing. The true incidence and economic impact of chronic wounds are difficult to assess because of the wide range of causative diseases and available treatment options. Despite multiple simultaneous and sequential therapeutic approaches, chronic wounds are highly resistant to treatment and are often indolent or even slowly progressive. Hyperbaric oxygen therapy (HBOT) has been explored as a treatment modality for chronic wounds because of its potential to promote healing and reduce bioburden in the wound bed. Multiple potential beneficial effects for wound healing have been demonstrated in various laboratory studies and experimental animal models. In this manuscript, HBOT, its mechanism of action, adverse effects and usage in diabetic and nondiabetic chronic wounds have been reviewed.
ABSTRACT Keratinocyte damage and lichenoid-interface reaction are the two major pathologic findin... more ABSTRACT Keratinocyte damage and lichenoid-interface reaction are the two major pathologic findings in lichen planus (LP). Matrix metalloproteinases (MMPs) are proteinases that participate in extracellular matrix (ECM) degradation and may play an important role in basal membrane (BM) damage in LP. Fibronectin (FN) mediates a variety of cellular interactions with ECM and plays important roles in cell adhesion, migration, growth and differentiation. To determine MMP-2, MMP-3, MMP-9 and FN expressions in LP and discuss the possible associations. Skin biopsy samples of 55 patients with LP and 11 normal skin were investigated. Five discoid lupus erythematosus (DLE) and 5 chronic dermatitis (CD) samples were also examined for comparison. Immunochemical stainings were performed for MMP-2, MMP-3, MMP-9 and fibronectin. Weak or absent expressions of MMP-2 and MMP-3 in epidermis; and dense MMP-9 expression in dermal inflammatory infiltrate cells were detected in LP. FN expression was lost in epidermal basal layer and papillary dermis. Loss of MMP-2, MMP-3 and FN in LP can be explained with the destruction of the epidermal basal layer. Similar expressions of MMP-2 and MMP-3 both in LP and DLE implied that these MMPs may be involved in the pathogenesis of interface dermatitis.
Background: Psoriasis is a common chronic inflammatory disease. Having more information about pso... more Background: Psoriasis is a common chronic inflammatory disease. Having more information about psoriasis and comorbid diseases means that patients have more involvement in treatment. Aim: Evaluate the knowledge levels of psoriasis patients about the disease and comorbidities and also to determine participation in treatment decisions. Methods : Totally 103 patients over the age of 18 with diagnosed psoriasis were included into the study. A questionnaire including items on knowledge about disease and treatment options, comorbid diseases were filled out by the patients. Total knowledge score (TKS) was found by giving 1 point to the questions that the patients knew correctly. Results: Patients were well informed about their risk of depression (64.1%), but were less well informed about their risk of atherothrombotic disease (14.6%). %50.4 of the patients thought that psoriasis may be due to an internal organ disease. There was a negative correlation between the patient's age, the age of diagnosis and TKS. 42.7% wanted to leave the decision entirely to the physician. Conclusion: The results of this study showed that majority of patients with psoriasis are not aware of the increased risk of comorbid diseases and do not have enough knowledge about psoriasis.
Melanositik pigmente deri lezyonlarýnýn birbirinden ayýrýmý, planlanacak tedavi yaklaþýmý açýsýnd... more Melanositik pigmente deri lezyonlarýnýn birbirinden ayýrýmý, planlanacak tedavi yaklaþýmý açýsýndan önemlidir. Bu amaçla yapýlacak histopatolojik incelemeye alternatif olarak son zamanlarda preoperatif tanýsal doðruluðu belirgin arttýran dermoskopi yöntemi olarak ön plana çýkmýþtýr. Bu çalýþmada, sýkça karþýlaþtýðýmýz melanositik pigmente lezyonlardan olan nevus nevosellularislerde dermoskopinin histopatolojik incelemenin yerine geçip, geçemeyeceði araþtýrýlmýþtýr. Çalýþmamýzda, Eylül 1998-Haziran 1999 tarihleri arasýnda Celal Bayar Üniversitesi Týp Fakültesi Dermatoloji Anabilim Dalý Ben Takip Polikliniði' ne baþvuran 22 hastadaki toplam 25 nevus nevosellularis dermoskopik olarak incelendikten sonra alýnan biyopsi materyallerinin histopatolojik tetkiki yapýlmýþ ve her iki yöntemle konulan tanýlar karþýlaþtýrýlmýþtýr. Dermoskopik muayenede el dermatoskopu, slayt çekimlerinde Dermaphot kullanýlmýþtýr. Dermatoskopi ve histopatoloji yöntemlerinin tutarlýlýðýný ölçmek için Kappa analizi yapýlmýþtýr. Dermoskopik olarak 7 jonksiyonel nevus naevocellularis (NNC), 15 bileþik NNC, 3 intradermal NNC tanýsý konulurken, histopatolojik olarak 7 jonksiyonel NNC, 10 bileþik NNC, 8 intradermal NNC tanýsý konulmuþtur. Dermoskopik olarak 25 lezyonun 20'si (%80), histopatolojik tanýyla ayný tanýyý almýþtýr. Kappa istatistiðinde iki yöntemle konulan tanýlarýn iyi derecede tutarlý olduðu bulunmuþtur (K= 0.69). Noninvaziv taný yöntemi olarak son yýllarda ön plana çýkan dermoskopinin melanositik pigmente deri lezyonlarýndan nevus nevosellularislerin tanýsýnda ve ayrýmýnda histopatolojik incelemenin yerine geçemeyeceði sonucuna varýlmýþtýr. Dermoskopi, Melanositik pigmente deri lezyonlarý, Nevus nevosellularis, Histopatolojik inceleme.
Melanositik pigmente deri lezyonlarının birbirinden ayırımı, planlanacak tedavi yaklaşımı açısınd... more Melanositik pigmente deri lezyonlarının birbirinden ayırımı, planlanacak tedavi yaklaşımı açısından önemlidir. Bu amaçla yapılacak histopatolojik incelemeye alternatif olarak son zamanlarda preoperatif tanısal doğruluğu belirgin arttıran dermoskopi yöntemi olarak ön ...
Işıl Inanır primarily performed the diagnosis, treatment, and follow-up of the patient. Peyker Te... more Işıl Inanır primarily performed the diagnosis, treatment, and follow-up of the patient. Peyker Temiz performed the histopathological examination. Fatmagül Gülbaşaran drafted the manuscript, Kamer Gündüz revised it, and all other authors contributed revisions and approved the final manuscript.
Objective: It has been a debate whether phenotypic features are associated with increased risk of... more Objective: It has been a debate whether phenotypic features are associated with increased risk of coronary heart disease. Proposed explanations for this relation include biological aging, individual susceptibilities, and androgens which contribute to both the atherosclerotic process and dermatological signs. The results of the studies are inconsistent and most are not based on cardiovascular imaging techniques. Here, association between androphenotypic features and the risk and severity of coronary artery disease (CAD) in men is evaluated. Methods: This case–control study consists of 166 male patients with angiography-proven CAD and 160 age-gender-matched controls. Gensini score of angiograms (for severity of CAD) and phenotypic characteristics including androgenetic alopecia (AGA), thoracic hairiness (TH), hair graying a diagonal earlobe crease (DEC), and hairy ear (HE) were recorded. Men with well-established cardiovascular risk factors were excluded. Results: AGA, DEC, and HE were significantly more frequent in patients with CAD than controls (98.2% and 83.1% [P < 0.001], 61.4% and 23.8% [P < 0.001], 69.3% and 50.6% [P = 0.001], respectively). As the severity of AGA increased, the incidence of heart disease was increasing in patients. The presence of TH and AGA was found to be related to higher Gensini scores. Conclusion: The exact mechanism between these phenotypic features and CAD still remains to be elucidated. However, observation of visible aging signs is easy and inexpensive. AGA, HE, and DEC may be used as early screening tools for CAD.
Amaç: Layşmanyazın laboratuvar tanısı, kültür, mikroskopik inceleme, serolojik ve moleküler yönte... more Amaç: Layşmanyazın laboratuvar tanısı, kültür, mikroskopik inceleme, serolojik ve moleküler yöntemlere dayanır. Tüm dünyada kültür için sıklıkla Novy-MacNeal-Nicolle (NNN) besiyeri kullanılmaktadır. Moleküler tanı yöntemlerinin tanısal amaçlı kullanımı sonrası NNN besiyerinin duyarlılığı konusunda şüpheler oluşmuştur. Bu çalışmada, yeni bir besiyerinin etkinliğinin NNN besiyeri ve moleküler yöntemle karşılaştırılması amaçlanmıştır. Yöntemler: Manisa Celal Bayar Üniversitesi Tıp Fakültesi Tıbbi Parazitoloji Anabilim Dalı'na Kilis, Osmaniye, Bitlis, Gaziantep ve Manisa illerimizdeki sağlık merkezlerinden tanı veya doğrulama amacıyla kutanöz layşmanyaz (KL) şüpheli 22 ve viseral layşmanyaz (VL) şüpheli 4 hasta örneği gönderilmiştir. Bu illerdeki sağlık merkezlerine önceden hazırlanan besiyerleri gönderilmiş ve alınan klinik örneklerden bu besiyerlerine ekim yapılması istenmiştir. KL için alınan iğne aspirasyon sıvısı ve VL için kemik iliği örnekleri, NNN besiyerine ve yeni geliştirilen karaciğer ekstreli besiyerlerine eşzamanlı olarak ekilmiş, yayma preparatlarıyla birlikte kurumumuza gönderilmiştir. Yayma preparatları Giemsa yöntemiyle boyanarak incelenmiştir. Ayrıca bu materyallerde gerçek zamanlı polimeraz zincir reaksiyonu yöntemiyle parazit DNA'sı aranmıştır. Bulgular: 26 örneğin 14'ünde Leishmania amastigotları görülmüştür. Örneklerden NNN besiyerine ekilenlerin 8'inde, yeni besiyerine ekilenlerin ise 24'ünde promastigot üremesi görülmüştür. KL şüpheli 2 hastada her iki besiyerinde de parazit üretilememiştir. Genotiplendirme yapıldığında dermotropik yerleşim gösteren izolatların L. tropica, L. major ve L. infantum/donovani; viserotropik yerleşim gösteren izolatların ise L. tropica ve L. infantum/donovani olduğu saptanmıştır.
OBJECTIVES Leishmaniasis is a vector-borne disease and dogs may act as urban reservoirs. Turkey a... more OBJECTIVES Leishmaniasis is a vector-borne disease and dogs may act as urban reservoirs. Turkey and most of the Mediterranean basin countries are endemic for leishmaniasis. In this study, it is aimed to report the autochthonous leishmaniasis cases, with all the components of the infection cycle (reservoir, vector, and the host) in a region close to Europe. METHODS Nine human and four canine autochthonous leishmaniasis cases were included in the study. Direct microscopy, culture methods, serological, and molecular tests were applied to the samples obtained from the cases. RESULTS VL and CL patients consisted of 2 L.infantum, 1 L. donovani, 2 L. tropica, and 2 L. tropica,1 L. major,1 L. infantum infected patients respectively. CanL cases were infected with L. infantum, L. donovani, L. tropica, and L. major. CONCLUSIONS All the cases were autochthonous cases located in Manisa province. As Greece and all the Mediterranean basin countries in Europe share competent vectors, it is concluded that the detection of all 4 species of Leishmania parasites in such proximity to Europe poses an important public health threat for Europe. This study reports all four species of Leishmania spp., including L. major and L.donovani in close proximity to continental Europe.
We describe a 48-year-old woman with three erythematous nodules localized on the left forearm, wi... more We describe a 48-year-old woman with three erythematous nodules localized on the left forearm, with 2 months evolution. Histological and immunohistochemical examination revealed a CD30(+) large-cell lymphoma. Systemic involvement was not detected. The tumor regressed spontaneously within a week, after the incisional skin biopsy. In control skin biopsy, there was not any histological feature of lymphoma. No reactivation or any symptom of systemic disease was observed during the 10-month follow-up period.
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