The opioid crisis has become one of the defining public health challenges of our time, profoundly... more The opioid crisis has become one of the defining public health challenges of our time, profoundly affecting individuals, families, and entire communities. To address this epidemic effectively, we must first explore its causes and the far- reaching consequences that continue to shape its devastating impact.
Assessing the Relationship between Opioid Therapy and Osteoporosis, 2024
Opioid use is extensively linked to adverse bone health outcomes, including increased risks of fr... more Opioid use is extensively linked to adverse bone health outcomes, including increased risks of fractures, impaired bone repair, and diminished bone mineral density (BMD). Opioids such as morphine and dilaudid inhibit bone formation, leading to bone loss, while chronic opioid use exacerbates bone turnover and suppresses bone formation. These effects, observed in both males and females, frequently result in osteoporosis. Opioid-induced endocrinopathies, including hypogonadism and testosterone deficiency, significantly contribute to decreased bone density and heightened fracture risk. Observational studies report a higher prevalence of hip fractures among chronic opioid users, emphasising the necessity of routine BMD screening, particularly in high-risk populations. The interaction between opioid use and bone health mandates comprehensive monitoring and risk assessment strategies for long-term opioid users.
Ginger has been traditionally used in Indian and Chinese medicine for its anti-emetic, anti-infla... more Ginger has been traditionally used in Indian and Chinese medicine for its anti-emetic, anti-inflammatory, and digestive properties. Scientific studies confirm its efficacy in reducing nausea and inflammation, and promoting digestive health. Ethnobotanical surveys emphasise its cultural significance and widespread use across various communities. Additionally, ginger's role in pharmaceuticals, dietary supplements, and functional foods highlights its pharmacological benefits and culinary versatility. In skincare, ginger shows promise for its antioxidant and anti-inflammatory effects, supporting its application in cosmetic formulations. Furthermore, ginger emerges as a multifaceted herb with significant therapeutic potential, rooted in traditional knowledge and validated by modern research. Its bioactive compounds, including gingerols and shogaols, contribute to its diverse health benefits, ranging from gastrointestinal support to skincare applications.
Paediatric pain management necessitates a comprehensive approach that integrates both pharmacolog... more Paediatric pain management necessitates a comprehensive approach that integrates both pharmacological and non-pharmacological strategies to address the complex pain experiences of children. The continued reliance on opioids highlights the importance of exploring opioid-sparing alternatives through multidisciplinary treatments. Nurses are integral to effective paediatric pain management, highlighting the necessity for rigorous training programs for student nurses. Efforts to improve pain management globally focus on enhancing the competencies of healthcare professionals through updated guidelines and continuous education. Cultural and contextual factors, exemplified by practices observed in hospitals, significantly influence pain management approaches. Despite advancements, persistent issues such as pain undertreatment indicate a need for greater knowledge among healthcare providers, including community pharmacists. Educational initiatives and innovative non-pharmacological interventions, such as virtual reality, have demonstrated potential in improving pain relief. However, the implementation of these strategies remains challenging, particularly in resource-constrained settings.
A succinct overview of pain management in Rheumatoid Arthritis (RA), covering causes, symptoms, a... more A succinct overview of pain management in Rheumatoid Arthritis (RA), covering causes, symptoms, and treatment options such as DMARDs and NSAIDs. It highlights the persistent challenge of RA pain despite advancements in treatment. The exploration of opioids as an analgesic option includes their mechanisms of action and clinical efficacy. Patient perspectives on opioid therapy and considerations for clinical practice are discussed. Additionally, it addresses multimodal approaches beyond opioids, emphasising personalised strategies. Concluding with recommendations, it offers guidance for navigating the complexities of RA pain management effectively.
The global fight against tuberculosis (TB) continues to be a pressing challenge, with millions of... more The global fight against tuberculosis (TB) continues to be a pressing challenge, with millions of lives affected by this infectious disease each year. According to the World Health Organisation (WHO), TB remains one of the top 10 causes of death worldwide, despite being preventable and curable.
In recent years, the involvement of patients in drug safety monitoring during regular clinical pr... more In recent years, the involvement of patients in drug safety monitoring during regular clinical practice has gained significant importance. The World Health Organisation defines pharmacovigilance as a process that includes identifying, evaluating, comprehending, and preventing adverse drug reactions (ADRs) and other drug-related problems.
In educational enquiry, paradigm refer to the broad frameworks of thought that guide the way rese... more In educational enquiry, paradigm refer to the broad frameworks of thought that guide the way research is conducted and interpreted. There are several different paradigms in educational enquiry, each with its own set of assumptions and methodologies.
The prevalence of multi-morbidity has been on the rise, with a growing number of individuals expe... more The prevalence of multi-morbidity has been on the rise, with a growing number of individuals experiencing the burden of two or more chronic conditions. Patients with multi-morbidity are frequently perceived as a complex and vulnerable group with a high mortality risk and extensive utilisation of healthcare, and they often express dissatisfaction with their care. Globally, primary healthcare institutions endeavour to improve patient-centered care, which is characterised as healthcare that is considerate and adaptable to individual patient preferences, requirements, and principles, with patient values directing all clinical decisions.
Background: Obesity is a worldwide issue that is associated with both health and socioeconomic im... more Background: Obesity is a worldwide issue that is associated with both health and socioeconomic implications. Conventional obesity management strategies have failed to sustain weight loss in severely obese patients and are therefore short-lived. Currently, bariatric surgery appears to be the most promising form of effective treatment for severely obese patients. It is a safe and effective form of surgery that produces sustainable weight loss and alleviates obesity-related comorbidities.
Aim: The aim of this review is to explore the three types of bariatric surgery: Laparoscopic adjustable band (LAGB), Roux-en-Y gastric bypass (RYGB), Sleeve gastrectomy (SG), and their complications.
Method: The primary sources of literature for this review were acquired by searching MEDLINE (Ovid), Science Direct, and the Cochrane Library databases for associated articles to 14th February 2020. A combination of MeSH/Thesaurus terms and free-text terms were included in this search: bariatric surgery, gastric band, sleeve gastrectomy, adjustable gastric band, roux-en-Y gastric bypass, and obesity surgery.
Result: All three types of bariatric surgery have the potential to cause both mild and serious post-surgical complications. Although the most dominant and frequently performed bariatric surgery is the RYGB, the SG is an emerging and more favourable form of surgery for severely obese patients because of its tolerable morbidities and long-term weight loss.
Conclusion: Bariatric surgery is a safe and effective form of treatment for severely obese patients. The SG is becoming increasingly popular as a result of its favourable profile in maintaining weight loss and tolerable morbidities. The development of both early and late complications emphasises the importance of closely monitoring patients after bariatric surgery in order to detect any adverse events, as late complications may manifest as life-threatening emergencies.
Opioids commonly used for pain relief may lead to hypogonadism, which is characterised by suppres... more Opioids commonly used for pain relief may lead to hypogonadism, which is characterised by suppression of production of the gonadotropin-releasing hormone (GnRH) resulting in inadequate production of sex hormones. The aim of this narrative review was to highlight the effects of opioids on the endocrine system and the development of hypogonadism. MEDLINE, EMBASE and Cochrane Library were searched for relevant articles investigating hypogonadism in patients undertaking opioid therapy by using a combination of both indexing and free-text terms. The suppression of GnRH leading to a decrease in sex hormones has been described as the principal mechanism of opioid-induced hypogonadism. However, there is no consensus on the threshold for the clinical diagnosis of hypogonadism. Evidence indicates that chronic opioid use can lead to hypogonadism. Clinicians should be aware of symptomatology associated with hypogonadism and should regularly monitor patients with appropriate laboratory investigations.
The opioid crisis has become one of the defining public health challenges of our time, profoundly... more The opioid crisis has become one of the defining public health challenges of our time, profoundly affecting individuals, families, and entire communities. To address this epidemic effectively, we must first explore its causes and the far- reaching consequences that continue to shape its devastating impact.
Assessing the Relationship between Opioid Therapy and Osteoporosis, 2024
Opioid use is extensively linked to adverse bone health outcomes, including increased risks of fr... more Opioid use is extensively linked to adverse bone health outcomes, including increased risks of fractures, impaired bone repair, and diminished bone mineral density (BMD). Opioids such as morphine and dilaudid inhibit bone formation, leading to bone loss, while chronic opioid use exacerbates bone turnover and suppresses bone formation. These effects, observed in both males and females, frequently result in osteoporosis. Opioid-induced endocrinopathies, including hypogonadism and testosterone deficiency, significantly contribute to decreased bone density and heightened fracture risk. Observational studies report a higher prevalence of hip fractures among chronic opioid users, emphasising the necessity of routine BMD screening, particularly in high-risk populations. The interaction between opioid use and bone health mandates comprehensive monitoring and risk assessment strategies for long-term opioid users.
Ginger has been traditionally used in Indian and Chinese medicine for its anti-emetic, anti-infla... more Ginger has been traditionally used in Indian and Chinese medicine for its anti-emetic, anti-inflammatory, and digestive properties. Scientific studies confirm its efficacy in reducing nausea and inflammation, and promoting digestive health. Ethnobotanical surveys emphasise its cultural significance and widespread use across various communities. Additionally, ginger's role in pharmaceuticals, dietary supplements, and functional foods highlights its pharmacological benefits and culinary versatility. In skincare, ginger shows promise for its antioxidant and anti-inflammatory effects, supporting its application in cosmetic formulations. Furthermore, ginger emerges as a multifaceted herb with significant therapeutic potential, rooted in traditional knowledge and validated by modern research. Its bioactive compounds, including gingerols and shogaols, contribute to its diverse health benefits, ranging from gastrointestinal support to skincare applications.
Paediatric pain management necessitates a comprehensive approach that integrates both pharmacolog... more Paediatric pain management necessitates a comprehensive approach that integrates both pharmacological and non-pharmacological strategies to address the complex pain experiences of children. The continued reliance on opioids highlights the importance of exploring opioid-sparing alternatives through multidisciplinary treatments. Nurses are integral to effective paediatric pain management, highlighting the necessity for rigorous training programs for student nurses. Efforts to improve pain management globally focus on enhancing the competencies of healthcare professionals through updated guidelines and continuous education. Cultural and contextual factors, exemplified by practices observed in hospitals, significantly influence pain management approaches. Despite advancements, persistent issues such as pain undertreatment indicate a need for greater knowledge among healthcare providers, including community pharmacists. Educational initiatives and innovative non-pharmacological interventions, such as virtual reality, have demonstrated potential in improving pain relief. However, the implementation of these strategies remains challenging, particularly in resource-constrained settings.
A succinct overview of pain management in Rheumatoid Arthritis (RA), covering causes, symptoms, a... more A succinct overview of pain management in Rheumatoid Arthritis (RA), covering causes, symptoms, and treatment options such as DMARDs and NSAIDs. It highlights the persistent challenge of RA pain despite advancements in treatment. The exploration of opioids as an analgesic option includes their mechanisms of action and clinical efficacy. Patient perspectives on opioid therapy and considerations for clinical practice are discussed. Additionally, it addresses multimodal approaches beyond opioids, emphasising personalised strategies. Concluding with recommendations, it offers guidance for navigating the complexities of RA pain management effectively.
The global fight against tuberculosis (TB) continues to be a pressing challenge, with millions of... more The global fight against tuberculosis (TB) continues to be a pressing challenge, with millions of lives affected by this infectious disease each year. According to the World Health Organisation (WHO), TB remains one of the top 10 causes of death worldwide, despite being preventable and curable.
In recent years, the involvement of patients in drug safety monitoring during regular clinical pr... more In recent years, the involvement of patients in drug safety monitoring during regular clinical practice has gained significant importance. The World Health Organisation defines pharmacovigilance as a process that includes identifying, evaluating, comprehending, and preventing adverse drug reactions (ADRs) and other drug-related problems.
In educational enquiry, paradigm refer to the broad frameworks of thought that guide the way rese... more In educational enquiry, paradigm refer to the broad frameworks of thought that guide the way research is conducted and interpreted. There are several different paradigms in educational enquiry, each with its own set of assumptions and methodologies.
The prevalence of multi-morbidity has been on the rise, with a growing number of individuals expe... more The prevalence of multi-morbidity has been on the rise, with a growing number of individuals experiencing the burden of two or more chronic conditions. Patients with multi-morbidity are frequently perceived as a complex and vulnerable group with a high mortality risk and extensive utilisation of healthcare, and they often express dissatisfaction with their care. Globally, primary healthcare institutions endeavour to improve patient-centered care, which is characterised as healthcare that is considerate and adaptable to individual patient preferences, requirements, and principles, with patient values directing all clinical decisions.
Background: Obesity is a worldwide issue that is associated with both health and socioeconomic im... more Background: Obesity is a worldwide issue that is associated with both health and socioeconomic implications. Conventional obesity management strategies have failed to sustain weight loss in severely obese patients and are therefore short-lived. Currently, bariatric surgery appears to be the most promising form of effective treatment for severely obese patients. It is a safe and effective form of surgery that produces sustainable weight loss and alleviates obesity-related comorbidities.
Aim: The aim of this review is to explore the three types of bariatric surgery: Laparoscopic adjustable band (LAGB), Roux-en-Y gastric bypass (RYGB), Sleeve gastrectomy (SG), and their complications.
Method: The primary sources of literature for this review were acquired by searching MEDLINE (Ovid), Science Direct, and the Cochrane Library databases for associated articles to 14th February 2020. A combination of MeSH/Thesaurus terms and free-text terms were included in this search: bariatric surgery, gastric band, sleeve gastrectomy, adjustable gastric band, roux-en-Y gastric bypass, and obesity surgery.
Result: All three types of bariatric surgery have the potential to cause both mild and serious post-surgical complications. Although the most dominant and frequently performed bariatric surgery is the RYGB, the SG is an emerging and more favourable form of surgery for severely obese patients because of its tolerable morbidities and long-term weight loss.
Conclusion: Bariatric surgery is a safe and effective form of treatment for severely obese patients. The SG is becoming increasingly popular as a result of its favourable profile in maintaining weight loss and tolerable morbidities. The development of both early and late complications emphasises the importance of closely monitoring patients after bariatric surgery in order to detect any adverse events, as late complications may manifest as life-threatening emergencies.
Opioids commonly used for pain relief may lead to hypogonadism, which is characterised by suppres... more Opioids commonly used for pain relief may lead to hypogonadism, which is characterised by suppression of production of the gonadotropin-releasing hormone (GnRH) resulting in inadequate production of sex hormones. The aim of this narrative review was to highlight the effects of opioids on the endocrine system and the development of hypogonadism. MEDLINE, EMBASE and Cochrane Library were searched for relevant articles investigating hypogonadism in patients undertaking opioid therapy by using a combination of both indexing and free-text terms. The suppression of GnRH leading to a decrease in sex hormones has been described as the principal mechanism of opioid-induced hypogonadism. However, there is no consensus on the threshold for the clinical diagnosis of hypogonadism. Evidence indicates that chronic opioid use can lead to hypogonadism. Clinicians should be aware of symptomatology associated with hypogonadism and should regularly monitor patients with appropriate laboratory investigations.
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Papers by Koddus Ali
bone mineral density (BMD). Opioids such as morphine and dilaudid inhibit bone formation, leading to bone loss, while chronic
opioid use exacerbates bone turnover and suppresses bone formation. These effects, observed in both males and females, frequently
result in osteoporosis. Opioid-induced endocrinopathies, including hypogonadism and testosterone deficiency, significantly contribute
to decreased bone density and heightened fracture risk. Observational studies report a higher prevalence of hip fractures among chronic
opioid users, emphasising the necessity of routine BMD screening, particularly in high-risk populations. The interaction between opioid
use and bone health mandates comprehensive monitoring and risk assessment strategies for long-term opioid users.
Aim: The aim of this review is to explore the three types of bariatric surgery: Laparoscopic adjustable band (LAGB), Roux-en-Y gastric bypass (RYGB), Sleeve gastrectomy (SG), and their complications.
Method: The primary sources of literature for this review were acquired by searching MEDLINE (Ovid), Science Direct, and the Cochrane Library databases for associated articles to 14th February 2020. A combination of MeSH/Thesaurus terms and free-text terms were included in this search: bariatric surgery, gastric band, sleeve gastrectomy, adjustable gastric band, roux-en-Y gastric bypass, and obesity surgery.
Result: All three types of bariatric surgery have the potential to cause both mild and serious post-surgical complications. Although the most dominant and frequently performed bariatric surgery is the RYGB, the SG is an emerging and more favourable form of surgery for severely obese patients because of its tolerable morbidities and long-term weight loss.
Conclusion: Bariatric surgery is a safe and effective form of treatment for severely obese patients. The SG is becoming increasingly popular as a result of its favourable profile in maintaining weight loss and tolerable morbidities. The development of both early and late complications emphasises the importance of closely monitoring patients after bariatric surgery in order to detect any adverse events, as late complications may manifest as life-threatening emergencies.
bone mineral density (BMD). Opioids such as morphine and dilaudid inhibit bone formation, leading to bone loss, while chronic
opioid use exacerbates bone turnover and suppresses bone formation. These effects, observed in both males and females, frequently
result in osteoporosis. Opioid-induced endocrinopathies, including hypogonadism and testosterone deficiency, significantly contribute
to decreased bone density and heightened fracture risk. Observational studies report a higher prevalence of hip fractures among chronic
opioid users, emphasising the necessity of routine BMD screening, particularly in high-risk populations. The interaction between opioid
use and bone health mandates comprehensive monitoring and risk assessment strategies for long-term opioid users.
Aim: The aim of this review is to explore the three types of bariatric surgery: Laparoscopic adjustable band (LAGB), Roux-en-Y gastric bypass (RYGB), Sleeve gastrectomy (SG), and their complications.
Method: The primary sources of literature for this review were acquired by searching MEDLINE (Ovid), Science Direct, and the Cochrane Library databases for associated articles to 14th February 2020. A combination of MeSH/Thesaurus terms and free-text terms were included in this search: bariatric surgery, gastric band, sleeve gastrectomy, adjustable gastric band, roux-en-Y gastric bypass, and obesity surgery.
Result: All three types of bariatric surgery have the potential to cause both mild and serious post-surgical complications. Although the most dominant and frequently performed bariatric surgery is the RYGB, the SG is an emerging and more favourable form of surgery for severely obese patients because of its tolerable morbidities and long-term weight loss.
Conclusion: Bariatric surgery is a safe and effective form of treatment for severely obese patients. The SG is becoming increasingly popular as a result of its favourable profile in maintaining weight loss and tolerable morbidities. The development of both early and late complications emphasises the importance of closely monitoring patients after bariatric surgery in order to detect any adverse events, as late complications may manifest as life-threatening emergencies.