FRAT1

FRAT1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1GNG, 3ZRK, 3ZRL, 3ZRM, 4AFJ
Identifikatori
Aliasi	FRAT1
Vanjski ID-jevi	OMIM: 602503 MGI: 109450 HomoloGene: 3999 GeneCards: FRAT1
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	97,321,915 bp
Lokacija gena (miš)
Hrom.	Hromosom 19 (miš)
Kraj	41,821,022 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citosol; • intracellular membrane-bounded organelle; • citoplazma;
Biološki proces	• Wnt-signalni put; • beta-catenin destruction complex disassembly; • canonical Wnt signaling pathway; • positive regulation of canonical Wnt signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	10023
	14296
	ENSG00000165879
	ENSMUSG00000067199
	Q92837
	P70339
	NM_181355; NM_005479
	NM_008043
	NP_005470
	NP_032069
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Proto-onkogen FRAT1 je protein koji je kod ljudi kodiran genom FRAT1.^[5]^[6]

Protein kodiran ovim genom pripada porodici proteina koji se vezuju za GSK-3. Može funkcionirati u progresiji tumora i u limfomageneze.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 279 aminokiselina, а molekulska težina 29.093 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPCRREEEEE	AGEEAEGEEE	EEDSFLLLQQ	SVALGSSGEV	DRLVAQIGET
LQLDAAQHSP	ASPCGPPGAP	LRAPGPLAAA	VPADKARSPA	VPLLLPPALA
ETVGPAPPGV	LRCALGDRGR	VRGRAAPYCV	AELATGPSAL	SPLPPQADLD
GPPGAGKQGI	PQPLSGPCRR	GWLRGAAASR	RLQQRRGSQP	ETRTGDDDPH
RLLQQLVLSG	NLIKEAVRRL	HSRRLQLRAK	LPQRPLLGPL	SAPVHEPPSP
RSPRAACSDP	GASGRAQLRT	GDGVLVPGS

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165879 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067199 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A (Mar 1997). "Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas". EMBO J. 16 (3): 441–50. doi:10.1093/emboj/16.3.441. PMC 1169648. PMID 9034327.
^ ^a ^b "Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas".
^ "UniProt, Q92837". Pristupljeno 2. 9. 2021.

Dopunska literatura

Li L, Yuan H, Weaver CD, et al. (1999). "Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1". EMBO J. 18 (15): 4233–40. doi:10.1093/emboj/18.15.4233. PMC 1171499. PMID 10428961.
Saitoh T, Katoh M (2001). "FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer". Int. J. Oncol. 19 (2): 311–5. doi:10.3892/ijo.19.2.311. PMID 11445844.
Bax B, Carter PS, Lewis C, et al. (2002). "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation". Structure. 9 (12): 1143–52. doi:10.1016/S0969-2126(01)00679-7. PMID 11738041.
Saitoh T, Mine T, Katoh M (2002). "Molecular cloning and expression of proto-oncogene FRAT1 in human cancer". Int. J. Oncol. 20 (4): 785–9. doi:10.3892/ijo.20.4.785. PMID 11894125.
Freemantle SJ, Portland HB, Ewings K, et al. (2002). "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2". Gene. 291 (1–2): 17–27. doi:10.1016/S0378-1119(02)00594-2. PMID 12095675.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hino S, Michiue T, Asashima M, Kikuchi A (2003). "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin". J. Biol. Chem. 278 (16): 14066–73. doi:10.1074/jbc.M213265200. PMID 12556519.
Khambata-Ford S, Liu Y, Gleason C, et al. (2003). "Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay". Genome Res. 13 (7): 1765–74. doi:10.1101/gr.529803. PMC 403750. PMID 12805274.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang Y, Hewitt SM, Liu S, et al. (2006). "Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours". Br. J. Cancer. 94 (5): 686–91. doi:10.1038/sj.bjc.6602988. PMC 2361213. PMID 16479254.
Hagen T, Cross DA, Culbert AA, et al. (2007). "FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A." J. Biol. Chem. 281 (46): 35021–9. doi:10.1074/jbc.M607003200. PMID 16982607.

Vanjaki linkovi

FRAT1 lokacija ljudskog genoma UCSC Genome Browser.

FRAT1 detalji ljudskog genoma u UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165879 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067199 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9034327-5] Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A (Mar 1997). "Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas". EMBO J. 16 (3): 441–50. doi:10.1093/emboj/16.3.441. PMC 1169648. PMID 9034327.

[entrez-6] "Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas".

[UniProt-7] "UniProt, Q92837". Pristupljeno 2. 9. 2021.

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