Background and aims. Liver biopsy is the gold standard for diagnosis and staging of liver fibrosi... more Background and aims. Liver biopsy is the gold standard for diagnosis and staging of liver fibrosis, but it is invasive and has many complications that diminished its practice. Now, robust of non-invasive index for predicting fibrosis is very valuable. The aim of this study is to validate and determine the efficacy of noninvasive markers aspartate aminotransferase to platelet ratio (APRI), FIB4 and AFP versus Fibroscan for predicting the fibrosis stages of patients with chronic HCV infection. Methods: This crosssectional study included 621 patients with chronic hepatitis C infection attended out-patient clinic (Medical center Beni-Suef branch, the association of liver patient care, ELP, El-Mansoura) for HCV viral hepatitis treatment. The patients were diagnosed by RT-PCR. Sensitivity and specificity of APRI, FIb-4 and AFP were estimated by receiver operator characteristic curve (ROC) for predicting stage of fibrosis versus Fibroscan. Results: Compared to Fibroscan as standard at value 12 kPa, the sensitivity and specificity of APRI was (67% and 61% and AUC= 0.747), of FIb-4 was (77% and 72% and AUC = 0.769) and of AFP was (77% and 60% and AUC = 0.734) for predicting early stages of fibrosis (F0-F1-F2). However, with advanced liver fibrosis (F3-F4) compared to Fibroscan at value 15 kPa, the sensitivity and specificity of APRI was (100% and 95.3% and AUC= 0.960) and of FIb-4 was (100% and 87.4% and AUC= 0.879) and of AFP were (100% and 51% and AUC= 0.684) for predicting F4 fibrosis. Conclusion: Given the higher cost and reduced availability of Fibroscan, this study showed that, the non-invasive tests APRI, FIB-4 index and AFP are practically useful markers for diagnosis and monitoring of liver fibrosis among patients with chronic HCV patients especially with advanced liver fibrosis.
Background: The outbreak has harmed patients with multiple comorbidities and chronic conditions. ... more Background: The outbreak has harmed patients with multiple comorbidities and chronic conditions. The pandemic’s psychological impact is thought to change their routine of seeking medical care. Research Question or Hypothesis: During COVID-19, patients with chronic conditions may experience anxiety, depression, and stress, and their pattern of seeking medical care may change. Materials and Methods: In May 2021, a cross-sectional, web-based study of patients with chronic diseases was conducted. Eligible patients (1036) were assessed for psychological disorders, primarily depression, stress, and anxiety, using the DASS-21 scale, and their pattern of receiving medical care during COVID-19. Results: During the pandemic, 52.5% of the patients with chronic diseases were depressed, 57.9% were anxious, and 35.6% were stressed. Patients with chronic diseases who had moderate to severe depression (34.9% versus 45.1%, p = 0.001), moderate to severe anxiety (43.6% versus 53.8%, p = 0.001), or mo...
There seem to currently be no therapeutic medications found for the severe coronavirus infection ... more There seem to currently be no therapeutic medications found for the severe coronavirus infection in 2019 (COVID-19). In light of this, it has been hypothesized that the immunomodulatory treatment known as tocilizumab can lessen the inflammatory response that occurs in the respiratory system, speed up the process of clinical benefit, lower the risk of death, and avert the need for ventilators. This randomized controlled trial (RCT) studied patients with a proven infection of SARS-CoV-2 and hyperinflammatory reactions. The inclusion criteria included fever (body temperature > 38 °C), pulmonary infiltrates, or supplemental oxygen. The patients received either conventional treatment with one dose of either tocilizumab (8 mg per kilogram of body weight) or conventional treatment only. The subjects were randomized to receive either treatment with a 1:1 ratio. A time-to-event test was conducted to determine the time to intubation or death. There was an insignificant difference between t...
Patients with neurological comorbidities are more likely to develop severe COVID-19. We aimed to ... more Patients with neurological comorbidities are more likely to develop severe COVID-19. We aimed to detect the outcomes of COVID-19 patients with spontaneous intracerebral hemorrhage comorbidity and the role of enoxaparin in decreasing the mortality rate in these cases, even though enoxaparin is a potential cause of intracerebral hemorrhage. The patients were checked on to detect surveillance outcomes, the relationship between mortality and patient characteristics, and the relationship between enoxaparin and study outcomes. Chest condition and GCS improved in 67.9% of participants. Hematoma course increased in 49.1%. Midline-shift, brain-edema, and COVID symptoms improved in 67.9%. There was a non-significant difference in mortality regarding age and gender. There was a significant difference in mortality regarding treatment with enoxaparin; 75% of the patients who did not receive enoxaparin died. 92.6% of the patients who showed decreases in hematoma course were administered enoxapari...
Purpose This study aimed to assess the factors affecting the prehospital time delay of the injure... more Purpose This study aimed to assess the factors affecting the prehospital time delay of the injured patients arriving at the Emergency Department of Beni-Suef University Hospital in Upper Egypt. Materials and methods In this cross-sectional study, the following data were retrieved from the hospital records of 632 injured patients between 1/1/2018 and 31/3/2018: age, sex, residence, means of transportation to the hospital, prehospital time delay, consciousness level on admission, source of injury, and type of worst injury. Results The prehospital time delay (>one hour) of the injured patients was positively associated with age >60 years and rural residence but inversely associated with consciousness level with odds ratios (95% confidence intervals) of 5.14 (2.26–11.68), 3.49 (2.22–5.48), and 0.56 (0.32–0.96), respectively. Conclusion The prehospital time delay of the injured patients arriving at the Emergency Department of Beni-Suef University Hospital in Egypt was associated wi...
The goal of this study is to assess various aspects of blood transfusion services and blood safet... more The goal of this study is to assess various aspects of blood transfusion services and blood safety and assure the adherence of the studied blood banks to the WHO global blood safety guidelines in Beni-Suef blood banks. This cross-sectional study was conducted in 2018 by in depth interview in the University hospital blood bank and the regional blood bank of Beni-Suef governorate. The officially recognized and the nationally coordinated blood transfusion service (BTS) found in both banks. There is a national blood policy and a national BTS management committee in both banks. There is a medical director responsible for the BTS and a national quality system in both banks. There is a mechanism for calculating total BTS costs in both banks. The approximate cost in US$ of producing one unit of whole blood is approximately 10 dollars (about 170 LE) and a system of stock control in both banks. Both blood banks are working under the WHO guidelines for global blood safety.
Journal of the Egyptian Society of Parasitology, 2021
Trichomoniasis plays a crucial role in causing some health problems such as ectopic pregnancy, un... more Trichomoniasis plays a crucial role in causing some health problems such as ectopic pregnancy, undesirable outcomes of pregnancy and infertility. This study evaluated the role of T. vaginalis in infertile women and assessed the relationship between trichomoniasis and female infertility in unexplained primary or secondary infertilities. A total of 90 female patients suffered from infertility were examined for trichomoniasis by Giemsa stained wet mount smears as a diagnostic reference. The results showed that T. vaginalis was 9/90 (10%) by culture method with significance with primary unexplained infertility.
Journal of the Egyptian Society of Parasitology, 2020
Blastocystis is an opportunistic infection that is considered to cause gastro-intestinal symptoms... more Blastocystis is an opportunistic infection that is considered to cause gastro-intestinal symptoms,including inflammatory bowel syndrome (IBS). It was also found that diabetic patientsmight be at a higher risk of infection with intestinal parasites causing gastro-intestinal symptomsespecially Blastocystis. This study assessed the rate of Blastocystis infection in patientssuffering from IBS associated with diabetes mellitus (DM), in comparison with the non-diabeticIBS group. Two hundred stool samples were collected. All the participants were IBS-diagnosedpatients. It is noted that 100 were without any history of chronic diseases based on historytaking, while the other 100 were known to be diabetic. Blastocystis was diagnosed by directmicroscopy of wet preparations; Lugol's iodine staining after concentration, and ModifiedJones' Culture. Blastocystis was detected in 37%, 65%, & 87% samples, respectively in IBS diabeticpatients. But, the parasite was found in 21%, 25%, & 42% sam...
Journal of the Egyptian Society of Parasitology, May 1, 2022
Cryptosporidium spp. has an elevated incidence rate particularly in immune-compromised patients i... more Cryptosporidium spp. has an elevated incidence rate particularly in immune-compromised patients including chronic renal disease (CRD) patients. This study evaluated cryptosporidiosis among patients with chronic renal disease undergoing hemodialysis attending outpatient clinics
Background: Hepatitis C virus (HCV) screening, case finding and treatment is an urgent public hea... more Background: Hepatitis C virus (HCV) screening, case finding and treatment is an urgent public health issue and a national priority on health, social and economic levels. However, the high cost of the gold standard diagnostic test, polymerase chain reaction (PCR), and the inaccessibility of trustful laboratories in many areas pushed the epidemiologists to search for easier, cheaper and fieldapplicable screening tools to detect infected individuals and then to confirm only the positive cases by the expensive PCR testing. Methodology: A total of 558 blood samples were confirmed for diagnosis of HCV by qualitative and quantitative PCR as a reference test. Those samples, 178 positive cases of HCV and 380 negative samples were further, examined by the enzyme-linked immunosorbant assay (ELISA) and the InTec rapid diagnostic testing kit to detect and compare their sensitivity, specificity, accuracy and efficiency as mass screening tests. Results: Compared with the reference PCR test, the InTec rapid diagnostic test showed a sensitivity of 99.4%, a specificity of 98.7%, a positive predictive value of 97.3%, a negative predictive value of 99.7%, an accuracy percent of 98.9% and an error percent of 1.1%. These results were comparable to that of ELISA. Conclusions: The InTec rapid diagnostic testing kit is a simple, cheap, sensitive, specific and efficient test that can be used in the field for simple and rapid diagnosis of HCV infection. The accuracy of the InTec kits has implications for its use in clinical and outreach settings Such field diagnosis of HCV infection is essential for case finding, screening and surveillance of HCV and for all the efforts that are exerted to treat, control and combat the disease.
COVID-19 vaccine recipients are more likely to experience post-vaccination adverse events, which ... more COVID-19 vaccine recipients are more likely to experience post-vaccination adverse events, which are considered the source of concerns about vaccine safety. This study aims to describe the utilization of COVID-19 vaccines and the associated adverse events and their possible predictors among adult Egyptians. An online cross-sectional study was designed to collect data through a Google Form questionnaire in November 2021. Adults who received at least one dose of the COVID-19 vaccine were asked to report their experience with vaccination and associated adverse events. A total of 853 participants were included in the study after receiving Sinopharm/Sinovac (63%), AstraZeneca (27%), Pfizer-BioNTech (4.8%), and other vaccines (5.2%). Around 50% of participants thought that COVID-19 vaccines were safe, 30.8% advised others with vaccination, and 68.3% reported post-vaccination adverse events. The most commonly encountered adverse symptoms were injection site pain (82.5%), fatigue (67.4%), f...
Summary University students are at elevated risk for mental health problems. The COVID-19 pandemi... more Summary University students are at elevated risk for mental health problems. The COVID-19 pandemic and subsequent public health measures taken to combat it burdened the students’ life with additional dramatic psychological impacts. The aim of this study was to investigate the psychological impacts that affected the university students in Egypt during the COVID-19 pandemic. An online survey was sent to the Egyptian university students via all means of online communication during the first week of May 2020 by using a non-probability snowball sampling. A survey included a short version Depression Anxiety Stress Scale-21 (DASS-21) and socio-demographic data. Overall, 70.5, 53.6 and 47.8% of Egyptian students had depression, anxiety and stress, respectively. Being a female, having a relative or acquaintance infected with COVID-19, having a preexisting chronic disease and lacking of psychological support from families, community and universities increase the risk of depression, anxiety an...
Background: The American College of Clinical Pharmacy (ACCP) prepared clinical pharmacist compete... more Background: The American College of Clinical Pharmacy (ACCP) prepared clinical pharmacist competencies that have specific recommendations. Recently, many efforts to advance clinical pharmacy services in Egypt exist. The literature revealed that no country has assessed the extent of applicability of ACCP competencies in its current pharmacy practice setting. Egyptian pharmacists can provide feedback about applicability of such competencies in clinical pharmacy settings in Egypt. Objective: The objective of this study was to investigate the extent to which ACCP competencies were implemented by Egyptian clinical pharmacists and therefore evaluate development of clinical pharmacy practice in Egypt. The study also investigated factors affecting the applicability of such competencies in the current clinical pharmacy practice setting in Egypt. Methods: Four hundred and ninety-five randomly selected clinical pharmacists from several hospitals were invited to participate in a cross sectional...
Aim of the study: We aimed to evaluate soluble CD25 (sCD25) as a marker for hepatocellular carcin... more Aim of the study: We aimed to evaluate soluble CD25 (sCD25) as a marker for hepatocellular carcinoma (HCC) diagnosis. Material and methods: Eighty-eight subjects were enrolled in our study in the years 2017-2018. They were divided into three groups as follows: group 1-HCC group (n = 44) patients, represented by BCLC stage A (n = 16) patients, stage B (n = 14) patients and stage C (n = 14) patients for each stage. All HCC patients were on top of cirrhosis. Group 2-group of cirrhotic patients without HCC (n = 32); 50% of them were Child-Turcotte-Pugh class A (n = 16) while class B was represented only by 43.7% (n = 14) of patients. Group 3-control group (n = 12) of healthy subjects. Results: The levels of sCD25 and AFP were higher in HCC patients than cirrhotic and control groups without a statistically significant difference between the three groups (p-value > 0.05). For HCC presence, sensitivity and specificity of sCD25 were 86.4% and 29.5% respectively at a cutoff value of 1.1 × 10 3 pg/ml (AUC = 0.619, p-value = 0.054, PPV = 33.2%, NPV = 68.44%). For early detection of HCC, sCD25 had a sensitivity of 70.5% and a specificity of 30.9% at a cutoff value of 1.575 × 10 3 pg/ml (AUC = 0.577, p-value = 0.251, PPV = 58.5%, NPV = 43.1%), while the sensitivity and specificity of AFP were 75% and 62.5% respectively at a cutoff value of 9.5 ng/ml (AUC = 0.828, p = 0.000, PPV = 73.4%, NPV = 64.4%) in the same settings. Conclusions: sCD25 seems to offer no better detection rate of HCC compared to AFP with lower sensitivity and specificity.
The consumption of drugs of abuse among females in the Health Services is a frequent problem, but... more The consumption of drugs of abuse among females in the Health Services is a frequent problem, but oftenit is not diagnosed. Aims: We have analyzed the variations in the clinical profile of female patients came toobstetric emergency department in a period of sex months and made screening for various drugs to assessthe percentage of addicted females in this period of life. Secondly, we have assessed also the accuracy of thepresumptive method of detection compared to the confirmatory method. Method: Urine samples were takenfrom pregnant females came to obstetric emergency department, Beni Suef University hospital and wasscreened to detect the drugs of abuse that taken by these females by immunoassay and GC- mass and clinicalassessment of the babies were done. Results: from 300 females there were 20 cases Tramadol positiveby immunoassay but all of them were false positive when GC-mass was used. There was a questionedcross reactivity between Ranitidine and tramadol by Immunoassay needing...
Background and aims. Liver biopsy is the gold standard for diagnosis and staging of liver fibrosi... more Background and aims. Liver biopsy is the gold standard for diagnosis and staging of liver fibrosis, but it is invasive and has many complications that diminished its practice. Now, robust of non-invasive index for predicting fibrosis is very valuable. The aim of this study is to validate and determine the efficacy of noninvasive markers aspartate aminotransferase to platelet ratio (APRI), FIB4 and AFP versus Fibroscan for predicting the fibrosis stages of patients with chronic HCV infection. Methods: This crosssectional study included 621 patients with chronic hepatitis C infection attended out-patient clinic (Medical center Beni-Suef branch, the association of liver patient care, ELP, El-Mansoura) for HCV viral hepatitis treatment. The patients were diagnosed by RT-PCR. Sensitivity and specificity of APRI, FIb-4 and AFP were estimated by receiver operator characteristic curve (ROC) for predicting stage of fibrosis versus Fibroscan. Results: Compared to Fibroscan as standard at value 12 kPa, the sensitivity and specificity of APRI was (67% and 61% and AUC= 0.747), of FIb-4 was (77% and 72% and AUC = 0.769) and of AFP was (77% and 60% and AUC = 0.734) for predicting early stages of fibrosis (F0-F1-F2). However, with advanced liver fibrosis (F3-F4) compared to Fibroscan at value 15 kPa, the sensitivity and specificity of APRI was (100% and 95.3% and AUC= 0.960) and of FIb-4 was (100% and 87.4% and AUC= 0.879) and of AFP were (100% and 51% and AUC= 0.684) for predicting F4 fibrosis. Conclusion: Given the higher cost and reduced availability of Fibroscan, this study showed that, the non-invasive tests APRI, FIB-4 index and AFP are practically useful markers for diagnosis and monitoring of liver fibrosis among patients with chronic HCV patients especially with advanced liver fibrosis.
Background: The outbreak has harmed patients with multiple comorbidities and chronic conditions. ... more Background: The outbreak has harmed patients with multiple comorbidities and chronic conditions. The pandemic’s psychological impact is thought to change their routine of seeking medical care. Research Question or Hypothesis: During COVID-19, patients with chronic conditions may experience anxiety, depression, and stress, and their pattern of seeking medical care may change. Materials and Methods: In May 2021, a cross-sectional, web-based study of patients with chronic diseases was conducted. Eligible patients (1036) were assessed for psychological disorders, primarily depression, stress, and anxiety, using the DASS-21 scale, and their pattern of receiving medical care during COVID-19. Results: During the pandemic, 52.5% of the patients with chronic diseases were depressed, 57.9% were anxious, and 35.6% were stressed. Patients with chronic diseases who had moderate to severe depression (34.9% versus 45.1%, p = 0.001), moderate to severe anxiety (43.6% versus 53.8%, p = 0.001), or mo...
There seem to currently be no therapeutic medications found for the severe coronavirus infection ... more There seem to currently be no therapeutic medications found for the severe coronavirus infection in 2019 (COVID-19). In light of this, it has been hypothesized that the immunomodulatory treatment known as tocilizumab can lessen the inflammatory response that occurs in the respiratory system, speed up the process of clinical benefit, lower the risk of death, and avert the need for ventilators. This randomized controlled trial (RCT) studied patients with a proven infection of SARS-CoV-2 and hyperinflammatory reactions. The inclusion criteria included fever (body temperature > 38 °C), pulmonary infiltrates, or supplemental oxygen. The patients received either conventional treatment with one dose of either tocilizumab (8 mg per kilogram of body weight) or conventional treatment only. The subjects were randomized to receive either treatment with a 1:1 ratio. A time-to-event test was conducted to determine the time to intubation or death. There was an insignificant difference between t...
Patients with neurological comorbidities are more likely to develop severe COVID-19. We aimed to ... more Patients with neurological comorbidities are more likely to develop severe COVID-19. We aimed to detect the outcomes of COVID-19 patients with spontaneous intracerebral hemorrhage comorbidity and the role of enoxaparin in decreasing the mortality rate in these cases, even though enoxaparin is a potential cause of intracerebral hemorrhage. The patients were checked on to detect surveillance outcomes, the relationship between mortality and patient characteristics, and the relationship between enoxaparin and study outcomes. Chest condition and GCS improved in 67.9% of participants. Hematoma course increased in 49.1%. Midline-shift, brain-edema, and COVID symptoms improved in 67.9%. There was a non-significant difference in mortality regarding age and gender. There was a significant difference in mortality regarding treatment with enoxaparin; 75% of the patients who did not receive enoxaparin died. 92.6% of the patients who showed decreases in hematoma course were administered enoxapari...
Purpose This study aimed to assess the factors affecting the prehospital time delay of the injure... more Purpose This study aimed to assess the factors affecting the prehospital time delay of the injured patients arriving at the Emergency Department of Beni-Suef University Hospital in Upper Egypt. Materials and methods In this cross-sectional study, the following data were retrieved from the hospital records of 632 injured patients between 1/1/2018 and 31/3/2018: age, sex, residence, means of transportation to the hospital, prehospital time delay, consciousness level on admission, source of injury, and type of worst injury. Results The prehospital time delay (>one hour) of the injured patients was positively associated with age >60 years and rural residence but inversely associated with consciousness level with odds ratios (95% confidence intervals) of 5.14 (2.26–11.68), 3.49 (2.22–5.48), and 0.56 (0.32–0.96), respectively. Conclusion The prehospital time delay of the injured patients arriving at the Emergency Department of Beni-Suef University Hospital in Egypt was associated wi...
The goal of this study is to assess various aspects of blood transfusion services and blood safet... more The goal of this study is to assess various aspects of blood transfusion services and blood safety and assure the adherence of the studied blood banks to the WHO global blood safety guidelines in Beni-Suef blood banks. This cross-sectional study was conducted in 2018 by in depth interview in the University hospital blood bank and the regional blood bank of Beni-Suef governorate. The officially recognized and the nationally coordinated blood transfusion service (BTS) found in both banks. There is a national blood policy and a national BTS management committee in both banks. There is a medical director responsible for the BTS and a national quality system in both banks. There is a mechanism for calculating total BTS costs in both banks. The approximate cost in US$ of producing one unit of whole blood is approximately 10 dollars (about 170 LE) and a system of stock control in both banks. Both blood banks are working under the WHO guidelines for global blood safety.
Journal of the Egyptian Society of Parasitology, 2021
Trichomoniasis plays a crucial role in causing some health problems such as ectopic pregnancy, un... more Trichomoniasis plays a crucial role in causing some health problems such as ectopic pregnancy, undesirable outcomes of pregnancy and infertility. This study evaluated the role of T. vaginalis in infertile women and assessed the relationship between trichomoniasis and female infertility in unexplained primary or secondary infertilities. A total of 90 female patients suffered from infertility were examined for trichomoniasis by Giemsa stained wet mount smears as a diagnostic reference. The results showed that T. vaginalis was 9/90 (10%) by culture method with significance with primary unexplained infertility.
Journal of the Egyptian Society of Parasitology, 2020
Blastocystis is an opportunistic infection that is considered to cause gastro-intestinal symptoms... more Blastocystis is an opportunistic infection that is considered to cause gastro-intestinal symptoms,including inflammatory bowel syndrome (IBS). It was also found that diabetic patientsmight be at a higher risk of infection with intestinal parasites causing gastro-intestinal symptomsespecially Blastocystis. This study assessed the rate of Blastocystis infection in patientssuffering from IBS associated with diabetes mellitus (DM), in comparison with the non-diabeticIBS group. Two hundred stool samples were collected. All the participants were IBS-diagnosedpatients. It is noted that 100 were without any history of chronic diseases based on historytaking, while the other 100 were known to be diabetic. Blastocystis was diagnosed by directmicroscopy of wet preparations; Lugol's iodine staining after concentration, and ModifiedJones' Culture. Blastocystis was detected in 37%, 65%, & 87% samples, respectively in IBS diabeticpatients. But, the parasite was found in 21%, 25%, & 42% sam...
Journal of the Egyptian Society of Parasitology, May 1, 2022
Cryptosporidium spp. has an elevated incidence rate particularly in immune-compromised patients i... more Cryptosporidium spp. has an elevated incidence rate particularly in immune-compromised patients including chronic renal disease (CRD) patients. This study evaluated cryptosporidiosis among patients with chronic renal disease undergoing hemodialysis attending outpatient clinics
Background: Hepatitis C virus (HCV) screening, case finding and treatment is an urgent public hea... more Background: Hepatitis C virus (HCV) screening, case finding and treatment is an urgent public health issue and a national priority on health, social and economic levels. However, the high cost of the gold standard diagnostic test, polymerase chain reaction (PCR), and the inaccessibility of trustful laboratories in many areas pushed the epidemiologists to search for easier, cheaper and fieldapplicable screening tools to detect infected individuals and then to confirm only the positive cases by the expensive PCR testing. Methodology: A total of 558 blood samples were confirmed for diagnosis of HCV by qualitative and quantitative PCR as a reference test. Those samples, 178 positive cases of HCV and 380 negative samples were further, examined by the enzyme-linked immunosorbant assay (ELISA) and the InTec rapid diagnostic testing kit to detect and compare their sensitivity, specificity, accuracy and efficiency as mass screening tests. Results: Compared with the reference PCR test, the InTec rapid diagnostic test showed a sensitivity of 99.4%, a specificity of 98.7%, a positive predictive value of 97.3%, a negative predictive value of 99.7%, an accuracy percent of 98.9% and an error percent of 1.1%. These results were comparable to that of ELISA. Conclusions: The InTec rapid diagnostic testing kit is a simple, cheap, sensitive, specific and efficient test that can be used in the field for simple and rapid diagnosis of HCV infection. The accuracy of the InTec kits has implications for its use in clinical and outreach settings Such field diagnosis of HCV infection is essential for case finding, screening and surveillance of HCV and for all the efforts that are exerted to treat, control and combat the disease.
COVID-19 vaccine recipients are more likely to experience post-vaccination adverse events, which ... more COVID-19 vaccine recipients are more likely to experience post-vaccination adverse events, which are considered the source of concerns about vaccine safety. This study aims to describe the utilization of COVID-19 vaccines and the associated adverse events and their possible predictors among adult Egyptians. An online cross-sectional study was designed to collect data through a Google Form questionnaire in November 2021. Adults who received at least one dose of the COVID-19 vaccine were asked to report their experience with vaccination and associated adverse events. A total of 853 participants were included in the study after receiving Sinopharm/Sinovac (63%), AstraZeneca (27%), Pfizer-BioNTech (4.8%), and other vaccines (5.2%). Around 50% of participants thought that COVID-19 vaccines were safe, 30.8% advised others with vaccination, and 68.3% reported post-vaccination adverse events. The most commonly encountered adverse symptoms were injection site pain (82.5%), fatigue (67.4%), f...
Summary University students are at elevated risk for mental health problems. The COVID-19 pandemi... more Summary University students are at elevated risk for mental health problems. The COVID-19 pandemic and subsequent public health measures taken to combat it burdened the students’ life with additional dramatic psychological impacts. The aim of this study was to investigate the psychological impacts that affected the university students in Egypt during the COVID-19 pandemic. An online survey was sent to the Egyptian university students via all means of online communication during the first week of May 2020 by using a non-probability snowball sampling. A survey included a short version Depression Anxiety Stress Scale-21 (DASS-21) and socio-demographic data. Overall, 70.5, 53.6 and 47.8% of Egyptian students had depression, anxiety and stress, respectively. Being a female, having a relative or acquaintance infected with COVID-19, having a preexisting chronic disease and lacking of psychological support from families, community and universities increase the risk of depression, anxiety an...
Background: The American College of Clinical Pharmacy (ACCP) prepared clinical pharmacist compete... more Background: The American College of Clinical Pharmacy (ACCP) prepared clinical pharmacist competencies that have specific recommendations. Recently, many efforts to advance clinical pharmacy services in Egypt exist. The literature revealed that no country has assessed the extent of applicability of ACCP competencies in its current pharmacy practice setting. Egyptian pharmacists can provide feedback about applicability of such competencies in clinical pharmacy settings in Egypt. Objective: The objective of this study was to investigate the extent to which ACCP competencies were implemented by Egyptian clinical pharmacists and therefore evaluate development of clinical pharmacy practice in Egypt. The study also investigated factors affecting the applicability of such competencies in the current clinical pharmacy practice setting in Egypt. Methods: Four hundred and ninety-five randomly selected clinical pharmacists from several hospitals were invited to participate in a cross sectional...
Aim of the study: We aimed to evaluate soluble CD25 (sCD25) as a marker for hepatocellular carcin... more Aim of the study: We aimed to evaluate soluble CD25 (sCD25) as a marker for hepatocellular carcinoma (HCC) diagnosis. Material and methods: Eighty-eight subjects were enrolled in our study in the years 2017-2018. They were divided into three groups as follows: group 1-HCC group (n = 44) patients, represented by BCLC stage A (n = 16) patients, stage B (n = 14) patients and stage C (n = 14) patients for each stage. All HCC patients were on top of cirrhosis. Group 2-group of cirrhotic patients without HCC (n = 32); 50% of them were Child-Turcotte-Pugh class A (n = 16) while class B was represented only by 43.7% (n = 14) of patients. Group 3-control group (n = 12) of healthy subjects. Results: The levels of sCD25 and AFP were higher in HCC patients than cirrhotic and control groups without a statistically significant difference between the three groups (p-value > 0.05). For HCC presence, sensitivity and specificity of sCD25 were 86.4% and 29.5% respectively at a cutoff value of 1.1 × 10 3 pg/ml (AUC = 0.619, p-value = 0.054, PPV = 33.2%, NPV = 68.44%). For early detection of HCC, sCD25 had a sensitivity of 70.5% and a specificity of 30.9% at a cutoff value of 1.575 × 10 3 pg/ml (AUC = 0.577, p-value = 0.251, PPV = 58.5%, NPV = 43.1%), while the sensitivity and specificity of AFP were 75% and 62.5% respectively at a cutoff value of 9.5 ng/ml (AUC = 0.828, p = 0.000, PPV = 73.4%, NPV = 64.4%) in the same settings. Conclusions: sCD25 seems to offer no better detection rate of HCC compared to AFP with lower sensitivity and specificity.
The consumption of drugs of abuse among females in the Health Services is a frequent problem, but... more The consumption of drugs of abuse among females in the Health Services is a frequent problem, but oftenit is not diagnosed. Aims: We have analyzed the variations in the clinical profile of female patients came toobstetric emergency department in a period of sex months and made screening for various drugs to assessthe percentage of addicted females in this period of life. Secondly, we have assessed also the accuracy of thepresumptive method of detection compared to the confirmatory method. Method: Urine samples were takenfrom pregnant females came to obstetric emergency department, Beni Suef University hospital and wasscreened to detect the drugs of abuse that taken by these females by immunoassay and GC- mass and clinicalassessment of the babies were done. Results: from 300 females there were 20 cases Tramadol positiveby immunoassay but all of them were false positive when GC-mass was used. There was a questionedcross reactivity between Ranitidine and tramadol by Immunoassay needing...
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