File:DNA Repair.jpg
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[edit]DescriptionDNA Repair.jpg |
DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. A special enzyme, DNA ligase (shown here in color), encircles the double helix to repair a broken strand of DNA. DNA ligase is responsible for repairing the millions of DNA breaks generated during the normal course of a cell's life. Without molecules that can mend such breaks, cells can malfunction, die, or become cancerous. DNA ligases catalyse the crucial step of joining breaks in duplex DNA during DNA repair, replication and recombination, and require either Adenosine triphosphate (ATP) or Nicotinamide adenine dinucleotide (NAD+) as a cofactor. Shown here is DNA ligase I repairing chromosomal damage. The three visable protein structures are:
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Date | ||||||||||
Source | Biomedical Beat, Cool Image Gallery | |||||||||
Author | Tom Ellenberger, Washington University School of Medicine in St. Louis. | |||||||||
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current | 01:11, 27 January 2007 | 500 × 642 (109 KB) | DO11.10 (talk | contribs) | {{Information |Description= DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. A special enzyme, DNA ligase, encircles the |
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Software used | Adobe Photoshop CS Windows |
File change date and time | 15:42, 20 November 2006 |
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