SERPING1

SERPING1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2OAY
Dynodwyr
Cyfenwau	SERPING1, C1IN, C1INH, C1NH, HAE1, HAE2, serpin family G member 1
Dynodwyr allanol	OMIM: 606860 HomoloGene: 44 GeneCards: SERPING1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • GO:0001948, GO:0016582 protein binding • serine-type endopeptidase inhibitor activity Cydrannau o'r gell • blood microparticle • extracellular region • extracellular exosome • platelet alpha granule lumen • extracellular space • collagen-containing extracellular matrix Prosesau biolegol • hemostasis • blood coagulation, intrinsic pathway • negative regulation of peptidase activity • fibrinolysis • immune system process • GO:0010260 heneiddio • platelet degranulation • blood circulation • negative regulation of complement activation, lectin pathway • complement activation, classical pathway • innate immune response • negative regulation of endopeptidase activity • blood coagulation • regulation of complement activation • regulation of blood coagulation • negative regulation of complement activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	710	n/a
Ensembl	ENSG00000149131	n/a
UniProt	P05155	n/a
RefSeq (mRNA)	NM_001032295 NM_000062	n/a
RefSeq (protein)	NP_000053 NP_001027466	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPING1 yw SERPING1 a elwir hefyd yn Serpin family G member 1 a Plasma protease C1 inhibitor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q12.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPING1.

• C1IN
• C1NH
• HAE1
• HAE2
• C1INH

Llyfryddiaeth

• "Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice. ". PLoS One. 2017. PMID 29036225.
• "The role of the complement system in hereditary angioedema. ". Mol Immunol. 2017. PMID 28595743.
• "Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparumMerozoites. ". J Immunol. 2017. PMID 28484054.
• "Mutational spectrum of the SERPING1 gene in Swiss patients with hereditary angioedema. ". Clin Exp Immunol. 2017. PMID 28194776.
• "How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation.". Structure. 2016. PMID 27818099.