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Hippocampal Memory Prosthesis

Encyclopedia of Computational Neuroscience

Synonyms

Hippocampal cognitive prosthesis; Hippocampal prosthesis

Definition

Hippocampal memory prosthesis is a brain-machine interface device developed for restoring or enhancing memory functions (Berger et al. 2010, 2011, 2012; Hampson et al. 2012, 2013; Song et al. 2006). It is designed to circumvent damaged hippocampal tissue by reestablishing the ensemble coding of spike trains performed by a normal population of hippocampal neurons. The objective is to restore long-term memory function in a stimulus-specific manner using a multi-input/multi-output (MIMO) nonlinear dynamical model (Fig. 1).

Fig. 1
figure 1

Conceptual representation of a hippocampal memory prosthesis for the human. The biomimetic multi-input/multi-output (MIMO) model implemented in VLSI performs the same nonlinear transformation as a damaged portion of the hippocampus (red “X”). The VLSI device is connected “upstream” and “downstream” from the damaged hippocampal area through multisite electrode arrays

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References

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Authors and Affiliations

  1. Department of Biomedical Engineering, Center for Neural Engineering, University of Southern California, Los Angeles, CA, 90089-1451, USA

    Prof. Dong Song & Prof. Theodore W. Berger

Authors
  1. Prof. Dong Song
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  2. Prof. Theodore W. Berger
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Corresponding author

Correspondence to Dong Song .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Song, D., Berger, T.W. (2014). Hippocampal Memory Prosthesis. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_558-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_558-1

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Chapter history

  1. Latest

    Hippocampal Memory Prosthesis
    Published:
    11 March 2021

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_558-2

  2. Original

    Hippocampal Memory Prosthesis
    Published:
    01 April 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_558-1

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