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Darwinian evolution in the genealogy of haemoglobin

Nature volume 253, pages 603–608 (1975)Cite this article

Abstract

Frequencies of mutations between reconstructed ancestor and descendant sequences of codons for metazoan globin chains show that natural selection guided protein evolution. Mutations which improved haemoglobin function were accepted at an accelerated rate in the first vertebrates. Rates decelerated after functional opportunities had been exploited.

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Authors and Affiliations

  1. Department of Anatomy, Wayne State University, Detroit, Michigan, 48201

    Morris Goodman & G. William Moore

  2. Department of Biochemistry, Nagasaki University, School of Medicine, Nagasaki, Japan

    Genji Matsuda

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  1. Morris Goodman
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  3. Genji Matsuda
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Goodman, M., Moore, G. & Matsuda, G. Darwinian evolution in the genealogy of haemoglobin. Nature 253, 603–608 (1975). https://doi.org/10.1038/253603a0

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