Abstract
CARSWELL et al.1 described a tumour necrosis factor (TNF) in the sera of mice sensitised with BCG and injected with endotoxin. After intravenous injection of this serum into mice bearing a 7-d-old transplant of a tumour originally induced by methylcholanthrene, necrosis of the tumour began within 12–24 h. A similar response was found in mice bearing various other tumours. We have now found that both whole TNF serum and TNF partially purified from mouse serum2 inhibit the growth of a human melanoma cell line.
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References
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HELSON, L., GREEN, S., CARSWELL, E. et al. Effect of tumour necrosis factor on cultured human melanoma cells. Nature 258, 731–732 (1975). https://doi.org/10.1038/258731a0
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DOI: https://doi.org/10.1038/258731a0
