Abstract
More than 20 peptides have been identified in neurones of the brain, spinal cord and periphery. In several cases a peptide occurs together with a ‘classica’ transmitter in the same neurone. This raises new questions about the process of neurotransmission and may have important implications for our understanding and treatment of mental disorders.
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References
McLennan, H. Synaptic Transmission (Saunders, Philadelphia, 1963).
Nicoll, R. A. in Neuroscience Symposia Vol. 1 (eds Ferrendelli, J. A., McEwen, B. S. & Snyder, S. H.) 99–122 (Society for Neuroscience, Bethesda, 1976).
Otsuka, M. & Takahashi, T. A. Rev. Pharmac. Tox. 17, 425 (1977).
Fischer-Ferraro, C., Nahmod, V. E., Goldstein, D. J. & Finkielman, S. J. exp. Med. 133, 353 (1971).
Ganten, D. et al. Am. J. Physiol. 221, 1733 (1971).
Vanderhaeghen, J. J., Signeau, J. C. & Gepts, W. Nature 257, 604 (1975).
Dockray, G. J. Nature 264, 568 (1976).
Krieger, D. T. & Liotta, A. S. Science 205, 366 (1979).
Euler, U. S. von Noradrenaline (Thomas, Springfield, 1956).
Du Vigneaud, V. in Harvey Lectures 1954–55, 1–26 (Academic, New York, 1956).
Knowles, F. in Neurosecretion—The Final Neuroendocrine Pathway (eds Knowles, F. & Vollrath, L.) 3–11 (Springer, Berlin, 1974).
Schally, A. V., Arimura, A. & Kastin, A. J. Science 179, 341 (1973).
Guillemin, R. in The Hypothalamus (eds Reichlin, S., Baldessarini, R. J. & Martin, J. B.) 155–194 (Raven, New York, 1978).
Szentágothai, J., Flerko, B., Mess, B. & Halász, B. Hypothalamic Control of the Anterior Pituitary (Akádemiai Kiadó, Budapest 1962).
Yalow, R. S. Science 200, 1236 (1978).
Emson, P. Prog. Neurobiol. 13, 61 (1979).
Snyder, S. H. Science (in the press).
Hökfelt, T. et al. in Neural Peptides and Neuronal Communication (eds Costa, E. & Trabucchi, M.) (Raven, New York, in the press).
Pearse, A. G. E. J. Histochem. Cytochem. 17, 303 (1969).
Coons, A. H., Creech, H. J. & Jones, R. N. Proc. Soc. exp. Biol. 47, 200 (1941).
Livett, B. G. Int. Rev. Cytol. Suppl. 7, 53 (1978).
Jones, E. G. & Hartman, B. K. in A. Rev. Neurosci. 1, 215–296 (1978).
Vandesande, F. J. Neurosci. Meth. 1, 3 (1979).
Nakane, P. J. Histochem. Cytochem. 16, 557 (1968).
Tramu, G., Pillez, A. & Leonardelli, J. J. Histochem. Cytochem. 26, 322 (1978).
Coons, A. H. in General Cytochemical Methods (ed. Danielli, J. F.) 399 (Academic, New York, 1978).
Nakane, P. & Pierce, G. B. Jr J. Cell Biol. 33, 307 (1967).
Sternberger, L. A., Hardy, P. H., Cuculis, J. J. & Meyer, H. G. J. Histochem. Cytochem. 18, 315 (1970).
Ljungdahl, Å., Hökfelt, T. & Nilsson, G. Neuroscience 3, 861 (1978).
Chang, M. M., Leeman, S. E. & Niall, H. D. Nature new Biol. 232, 86 (1971).
Hughes, J. et al. Nature 258, 577 (1975).
Li, C. H. Nature 201, 924 (1964).
Guillemin, R., Ling, N. & Burgus, R. C. hebd. Séanc. Acad. Sci. Paris D282, 783 (1976).
Lewis, R. S., Stein, S., Gerber, L. D., Rubinstein, M. & Udenfriend, S. Proc. natn. Acad. Sci. U.S.A. 75, 4021 (1978).
Yang, H.-Y., Fratta, W., Hong, J. S., Diguilio, A. M. & Costa, E. Neuropharmacology 17, 433 (1978).
Kanagawa, K., Matsuo, H. & Igarishi, M. Biochem. biophys. Res. Commun. 68, 153 (1979).
Elde, R. P., Hökfelt, T., Johansson, O. & Terenius, L. Neuroscience 1, 349 (1976).
Hökfelt, T., Elde, R. P., Johansson, O., Terenius, L. & Stein, L. Neurosci. Lett. 5, 25 (1977).
Simantov, R., Kuhar, M. J., Uhl, G. K. & Snyder, S. H. Proc. natn. Acad. Sci. U.S.A. 74, 2167 (1977).
Watson, S. J., Akil, H., Sullivan, S. & Barchas, J. O. Life Sci. 21, 733 (1977).
Bloom, F., Battenberg, F., Rossier, J., Ling, N. & Guillemin, R. Proc. natn. Acad. Sci. U.S.A. 75, 1591 (1978).
Sar, M., Stumpf, W. E., Miller, R. J., Chang, K.-J. & Cuatrecasas, P. J. comp. Neurol. 186, 17 (1978).
Uhl, G., Goodman, R. R., Kuhar, N. J., Childers, S. R. & Snyder, S. H. Brain Res. 166, 75 (1979).
Larsson, L.-I., Childers, S. R. & Snyder, S. H. Nature 282, 407 (1979).
Rossier, J. et al. Proc. natn. Acad. Sci. U.S.A. 74, 5162 (1977).
Watson, S. J., Barchas, J. D. & Li, C. H. Proc. natn. Acad. Sci. U.S.A. 74, 5155 (1977).
Johansson, O. Histochemistry 58, 167 (1978).
Arimura, A. et al. Metabolism 27, Suppl. 1, 1139 (1978).
Dahlström, A. Eur. J. Pharmac. 5, 111 (1968).
Kreutzberg, G.-W. Proc. natn. Acad. Sci. U.S.A. 62, 722 (1969).
Lubinska, L., Niemiesko, S., Oderfeld, B. & Schwarc, L. J. Neurochem. 10, 25 (1963).
Goldsmith, P. C. Fedn Proc. 36, 1968 (1977).
Grille, M. & Palay, S. L. in Electron Microscopy Vol. 2 (ed. Breese, S. J. Jr) U-1 (Academic, New York, 1962).
Cuello, A. C. et al. in Centrally Acting Peptides (ed. Hughes, J.) 135–155 (Macmillan, London, 1978).
Iversen, L. L. The Uptake and Storage of Noradrenaline in Sympathetic Nerves (Cambridge University Press, 1967).
Gainer, H., Peng Loh, Y. & Sarne, Y. in Peptides in Neurobiohgy (ed. Gainer, H.) 183–219 (Plenum, New York, 1977).
Bloom, F. E. in Central Regulation of the Endocrine System (eds Fuxe, K., Hokfelt, T. & Luft, R.) 173–177 (Plenum, New York, 1978).
Said, S. I. & Faloona, G. R. New Engl. J. Med. 293, 155 (1975).
Larsson, L-I. et al. Proc. natn. Acad. Sci. U.S.A. 73, 3197 (1976).
Fuxe, K., Hokfelt, T., Said, S. & Mutt, V. Neurosci. Lett. 5, 241 (1977).
Gotto, A. M., Jr., Peck, E. J., Jr., & Boyd, A. E. III (eds) Brain Peptides: A New Endocrinology (North-Holland, Amsterdam, 1979).
Cuello, A. C. & Kanazawa, I. J. comp. Neurol. 178, 129 (1978).
Uhl, G. R., Goodman, R. R. & Snyder, S. H. Brain Res. 167, 77 (1979).
Innis, R. B., Correa, F. M. A., Uhl, G. R., Schneider, B. & Snyder, S. H. Proc. natn. Acad. Sci. U.S.A. 76, 521 (1979).
Larsson, L. I. & Rehfeld, I. F. Brain Res. 165, 201 (1979).
Lorén, I., Alumets, J., Håkanson, R. & Sundler, F. Histochemistry 59, 249 (1979).
Correa, T. M. A., Innis, R. B., Uhl, G. R. & Snyder, S. H. Proc. natn. Acad. Sci. U.S.A. 76, 1489 (1979).
Bloch, B., Bugnon, C., Fellman, D. & Lenys, D. Neurosci. Lett. 10, 147 (1978).
Watson, S. J., Akil, H., Richard, C. W. III & Barchas, J. D. Nature 275, 226 (1978).
Nilaver, G. et al. J. Cell Biol. 81, 50 (1979).
Johansson, O. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Emson, P. C. & Lindvall, O. Neuroscience 4, 1 (1979).
Barry, J., Dubois, M. P. & Poulain, P. Z. Zellforsch. 146, 351 (1973).
Calas, A., Kerdelhué, B., Assenmacher, I. & Jutisz, M. Cr. hebd. Séanc. Acad. Sci., Paris D277, 2765 (1973).
Leonardelli, J., Barry, J. & Dubois, M. P. C. r. hebd. Séanc. Acad. Sci., Paris D276, 2043 (1973).
Hokfelt, T. et al. in Neuroactive Drugs in Endocrinology (ed. Müller, E. E.) (North-Holland, Amsterdam, in the press).
Fuxe, K. Z. Zellforsch. mikrosk. Anat. 61, 710 (1964).
Walaas, J. & Fonnum, F. Brain Res. 153, 549 (1978).
Carson, K. A. et al. Brain Res. 129, 169 (1977).
Hökfelt, T. et al. Adv. Pharmac. Ther. 2, 131 (Pergamon, Oxford, 1979).
Lundberg, J. M. et al. Acta physiol. scand. 104, 499 (1978).
Barber, R. P. J. comp. Neurol. 184, 331 (1979).
Hökfelt, T. et al. Neuroscience 3, 517 (1978).
Hökfelt, T., Terenius, L., Kuypers, H. G. J. M. & Dann, O. Neurosci. Lett. 14, 55 (1979).
Hökfelt, T., Ljungdahl, Å., Terenius, L., Elde, R. P. & Nilsson, G. Proc. natn. Acad. Sci. U.S.A. 74, 3081 (1977).
Lembeck, F. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 219, 197 (1975).
Takahashi, T. & Otsuka, M. Brain Res. 87, 1 (1975).
Hökfelt, T., Kellerth, J.-O., Nilsson, G. & Pernow, B. Brain Res. 100, 235 (1975).
Hökfelt, T. et al. Neuroscience 1, 131 (1976).
Pernow, B. Acta physiol. scand. 105, Suppl. 29, 1 (1953).
Euler, U. S. von Ann. N. Y. Acad. Sci. 104, 449 (1963).
Gamse, R., Lembeck, F. & Cuello, A. C. Naunyn-Schmiedebergs Arch. exp. Pharmak. 306, 37 (1979).
Gilbert, R. F. T. et al. J. Neurochem. (in the press).
Brimijoin, S., Lundberg, J. M., Brodin, E., Nilsson, G. & Hökfelt, T. Brain Res (in the press).
Lundberg, J. M., Hokfelt, T., Änggård, A., Pernow, B. & Emson, P. Acta physiol. scand. 107, 401 (1979).
Henry, J. L. in Substance P (eds Euler, U. S. von & Pernow, B.) 231–240 (Raven, New York, 1977).
Hinsey, J. C. & Gasser, H. S. Am. J. Physiol. 92, 679 (1930).
Lembeck, F., Gamse, R. & Juan, H. in Substance P (eds Euler, U. S. von & Pernow, B.) 169–181 (Raven, New York, 1977).
Olgarth, L., Gazelius, B., Brodin, E. & Nilsson, G. Acta physiol. scand. 101, 510 (1977).
Olmsted, J. M. D. J. exp. Zool. 31, 369 (1920).
Poritsky, R. L. & Singer, M. J. exp. Zool. 153, 211 (1963).
Zalewski, A. A. Expl Neurol. 40, 161 (1974).
Schultzberg, M. et al. Neuroscience 4, 249 (1979).
Hökfelt, T. et al. Neuroscience 2, 885 (1977).
Hökfelt, T., Elfvin, L.-G., Schultzberg, M., Goldstein, M. & Nilsson, G. Brain Res. 132, 29 (1977).
Hokfelt, T. et al. Proc. natn. Acad. Sci. U.S.A. 74, 3587 (1977).
Kuntz, A. J. comp. Neurol. 69, 1 (1938).
Kreulen, D. L. & Szurszewski, J. H. J. Physiol., Lond. (in the press).
Änggård, A. et al. Acta physiol. scand. Suppl. 473, 50 (1979).
Krier, J., cited in Burnstock et al. NRP Bulletin 17, 377 (1979).
Pearse, A. G. E. & Polak, J. M. Histochemistry 41, 373 (1975).
Nilsson, G., Larsson, L.-I., Brodin, E., Pernow, B. & Sundler, F. Histochemistry 43, 97 (1975).
Franco, R., Costa, M. & Furness, J. B. Naunyn-Schmiedebergs Arch. exp. Pharmak, 307, 57 (1979).
Schultzberg, M. et al. Neuroscience (in the press).
Bryant, M. G. et al. Lancet i, 991 (1976).
Fuxe, K., Hökfelt, T., Said, S. & Mutt, V. Neurosci. Lett. 5, 241 (1977).
Hökfelt, T. et al. Acta endocr., Copenh. Suppl. 200, 5 (1975).
Costa, M., Patel, Y., Furness, J. B. & Arimura, A. Neurosci. Lett. 6, 215 (1977).
Alumets, J., Håkanson, R., Sundler, F. & Chang, K. J. Histochemistry 56, 187 (1978).
Linnoila, R. I., Diagustine, R. P., Miller, R. J., Chang, K. J. & Cuatrecasas, P. Neuroscience 3, 861 (1978).
Dockray, G. J., Vaillant, C. & Walsh, J. H. Neuroscience 4, 1561 (1979).
Ungerstedt, U. Acta physiol. scand. 82, Suppl. 367, 1 (1971).
Cowan, W. M. & Cuénod, M. (eds) The Use of Axonal Transport for Studies of Neuronal Connectivity (Elsevier, Amsterdam, 1975).
Kristensson, K., Olsson, Y. & Sjöstrand, J. Brain Res. 32, 32 (1971).
LaVail, J. H. & La Vail, M. M. Science 176, 1416 (1972).
Ljungdahl, Å., Hökfelt, T., Goldstein, M. & Park, D. Brain Res. 84 313 (1975).
Kuypers, H. G. J. M., Catsman-Berrevoets, C. A. & Padt, R. E. Neurosci. Lett. 6, 127 (1977).
Hokfelt, T. et al. Neurosci. Lett. Suppl. 3, S342 (1979).
Owman, Ch., Håkanson, R. & Sundler, F. Fedn Proc. 32, 1785 (1973).
Larsson, L.-I., Sundler, F. & Häkanson, R. in Progress in Gastrointestinal Endocrinology (ed. Thompson, J. C.) 169–195 (University of Texas Press, Austin, 1975).
Solcia, E., Capella, C., Vasalla, G. & Buffa, R. Int. Rev. Cytol. 22, 223 (1975).
Pearse, A. G. E. & Polak, J. M. Gut 12, 783 (1971).
Pearse, A. G. E. in Centrally Acting Peptides (ed. Hughes, J.) 49–57 (Macmillan, London, 1979).
Chan-Palay, V., Jonsson, G. & Palay, S. L. Proc. natn. Acad. Sci. U.S.A. 75, 1582 (1978).
Björklund, A., Emson, P. C., Gilbert, R. T. F. & Skagerberg, G. Br. J. Pharmac. 66, 112 P (1979).
Chan-Palay, V. Anat. Embryol. 156, 225 (1979).
Singer, E., Sperk, G., Placheta, P. & Leeman, S. E. Brain Res. 174, 326 (1979).
Lundberg, J. M. et al. in Neural Peptides and Neuronal Communication (eds Costa, E. & Trabucchi, M.) (Raven, New York, 1980).
Schultzberg, M. et al. Neuroscience 3, 1169 (1978).
Lundberg, J. M. et al. Proc. natn. Acad. Sci. U.S.A. 76, 4079 (1979).
Lundberg, J. M., Hokfelt, T., Fahrenkrug, J., Nilsson, G. & Terenius, L. Acta physiol. scand. 107, 279 (1979).
Hökfelt, T., Rehfeld, J., Skirboll, L., Ivemark, B. & Goldstein, M. Nature (in the press).
Lundberg, J. M. et al. Neuroscience 4, 1539 (1979).
Lundberg, J. M., Änggard, A., Fahrenkrug, J., Hökfelt, T. & Mutt, V. Proc. natn. Acad. Sci. U.S.A. (in the press).
Tranzer, J. P. & Thoenen, H. Experientia 23, 123 (1967).
Hökfelt, T. Z. Zellforsch. mikrosk. Anat. 91, 1 (1968).
Pickel, V. M., Reis, D. J. & Leeman, S. E. Brain Res. 12, 534 (1977).
Paasonen, M. K. & Vogt, M. J. Physiol., Lond. 131, 617 (1956).
Eccles, J. D. The Physiology of Nerve Cells (Johns Hopkins Press, Baltimore, 1957).
Burnstock, G. Neuroscience 1, 239 (1976).
Dahlström, A. & Fuxe, K. Acta physiol. scand. 62, Suppl. 232, 1 (1964).
Dale, H. H. & Feldberg, W. J. Physiol., Lond. 82, 121 (1934).
Sjoqvist, F. Nature 194, 298 (1962).
Buckley, G., Console, S. & Sjöqvist, F. Acta physiol. scand. 71, 348 (1967).
Heidenhain, R. Pflügers Arch. ges. Physiol. 5, 309 (1872).
Hilton, S. M. & Lewis, G.-P. J. Physiol., Lond. 128, 235 (1955).
Hilton, S. M. & Lewis, G.-P. J. Physiol., Lond. 129, 253 (1955).
Fahrenkrug, J. et al. J. Physiol., Lond. 284, 291 (1978).
Belcher, G. & Ryall, R. W. J. Physiol., Lond. 272, 105 (1977).
Krnjević, K. & Lekić, D. Can. J. Physiol. Pharmac. 55, 958 (1977).
Mizobe, F., Kozousek, V., Deanne, D. M. & Livett, B. G. Brain Res. 178, 555 (1979).
Agnati, L., Fuxe, K. & Hokfelt, T. in Neural Peptides and Neuronal Communication (eds Costa, E. & Trabucchi, M.) (Raven, New York, in the press).
Pearse, A. G. E., Polak, J. M. & Bloom, S. R. Gastroenterohgy 72, 746 (1977).
Andén, N.-E. et al. Acta physiol. scand. 67, 313 (1966).
Matthysse, S. W. & Kety, S. S. (eds) Catecholamines and Schizophrenia (Pergamon, Oxford, 1975).
Hökfelt et al. Eur. J. Pharmac. (submitted).
Yahr, M. D. (ed.) The Basal Ganglia ARNMD Vol. 55 (Raven, New York, 1977).
Carlsson, A. & Lindqvist, M. Acta pharmacol. tox. (Kbh) 20, 140 (1963).
DeWied, D. & Versteeg, D. H. G. Fedn Proc. 38, 2348 (1979).
Terenius, L. A. Rev. Pharmac. Tox. 18, 189 (1978).
Gibbs, J., Young, R. D. & Smith, G. P. Nature 245, 323 (1973).
Fitzsimons, J. T. Physiol. Rev. 52, 468 (1972).
Ganten, D., Hutchinson, J. S., Ganten, U. & Schelling, P. in Central Nervous Control of Sodium Balance: Relation to the Renin Angiotensin System (eds Kaufman, W. & Krause, D.) 35–44 (Thieme, Stuttgart, 1976).
Moss, R. L. A. Rev. Physiol. 41, 617 (1979).
Dreifuss, J. J. Ann. N.Y. Acad. Sci. 248, 184 (1975).
Barker, J. L. Physiol. Rev. 56, 435 (1976).
Renaud, L. P., Pittman, Q. J. & Blume, H. W. in Central Regulation of the Endocrine System (eds Fuxe, K., Hökfelt, T. & Luft, R.) 119–136 (Plenum, New York, 1979).
Lipton, M. A., DiMascio, A. & Killam, K. F. Psychopharmacology. A Generation of Progress (Raven, New York, 1978).
Usdin, E., Kopin, I. J. & Barchas, J. D. (eds) Catecholamines: Basic and Clinical Frontiers Vols 1 and 2 (Pergamon, New York, 1979).
Cheramy, A. et al. Brain Res. 155, 404 (1978).
Hökfelt, T. et al. in The Hypothalamus (eds Reichlin, S., Baldessarini, R. J. & Martin, J. B.) 69–135 (Raven, New York, 1978).
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Hökfelt, T., Johansson, O., Ljungdahl, Å. et al. Peptidergic neurones. Nature 284, 515–521 (1980). https://doi.org/10.1038/284515a0
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DOI: https://doi.org/10.1038/284515a0