Abstract
The primary visual cortex (area 17) of the Old World monkey is divided into alternating right- and left-eye dominance columns1–3 that are highly modifiable by visual experience during a critical period in development but display little morphological or physiological plasticity during adult life4,5. However, changes in immunocytochemical staining for a calcium/calmodulin-dependent protein kinase occur in visual cortical neurones of adult monkeys after brief monocular deprivation6 and concentrations of putative neurotransmitters or their related enzymes can be altered with changes in neuronal activity in other systems7–9. We therefore examined the effects of monocular deprivation on the immunocytochemical staining for γ-aminobutyric acid (GABA) and its synthetic enzyme, glutamic acid decarboxylase (GAD), in adult monkey area 17. The staining for GABA and GAD in neuronal somata and terminals was markedly reduced within ocular dominance columns associated with a removed or a visually deprived eye, suggesting that the GABA concentration in cortical neurones may depend on their levels of activity. Thus area 17 of adult monkeys may retain a greater degree of plasticity than previously recognized and sensory experience can profoundly affect transmitter levels, in the cortex, apparently by regulating levels of a synthetic enzyme.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
196,21 € per year
only 3,85 € per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hubel, D. H. & Wiesel, T. N. J. comp. Neurol. 146, 421–450 (1972).
Wiesel, T. N., Hubel, D. H. & Lam, D. M. K. Brain Res. 79, 273–279 (1974).
Kennedy, C. et al. Proc. natn. Acad. Sci. U.S.A. 73, 4230–4234 (1976).
Hubel, D. H., Wiesel, T. N. & LeVay, S. Phil. Trans. R. Soc. B278, 377–409 (1977).
LeVay, S., Wiesel, T. N. & Hubel, D. H. J. comp. Neurol. 191, 1–51 (1980).
Hendry, S. H. C. & Kennedy, M. B. Proc. natn. Acad. Sci. U.S.A. 83, 1536–1540 (1986).
Molinoff, P. B., Brimijoin, S., Weinshiboum, R. & Axelrod, J. Proc. natn. Acad. Sci. U.S.A. 66, 453–457 (1970).
Kessler, J. A. & Black, I. B. Brain Res. 234, 182–194 (1982).
Baker, H., Kawano, T., Margolis, F. L. & Joh, T. H. J. Neurosci. 3, 69–78 (1983).
Hendrickson, A. E., Hunt, S. P. & Wu, J.-Y. Nature 292, 605–607 (1981).
Horton, J. C. & Hubel, D. H. Nature 292, 762–764 (1981).
Bear, M. F., Schmechel, D. E. & Ebner, F. F. J. Neurosci. 5, 1262–1275 (1985).
Horton, J. C. Phil Trans. R. Soc. B304, 199–253 (1984).
Wong-Riley, M. & Carroll, E. W. Nature 281, 572–574 (1984).
Sillito, A. M. in The Cerebral Cortex Vol. 2 (eds Jones, E. G. & Peters, A.) 91–117 (Plenum, New York, 1984).
Blakemore, C., Vital-Durand, F. & Garey, L. J. Proc. R. Soc. B213, 399–423 (1981).
Sternberger, L. A. Immunocytochemistry (Wiley, New York, 1979).
Hsu, S. M. & Raine, L. J. Histochem. Cytochem. 29, 1349–1353 (1981).
Wong-Riley, M. T. T. Brain Res. 171, 11–28 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hendry, S., Jones, E. Reduction in number of immunostained GABAergic neurones in deprived-eye dominance columns of monkey area 17. Nature 320, 750–753 (1986). https://doi.org/10.1038/320750a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/320750a0
