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Deregulated c-fos expression interferes with normal bone development in transgenic mice

Nature volume 325, pages 412–416 (1987)Cite this article

Abstract

Transgenic mice were generated expressing c-fos genes under the control of the human metallothionein promoter. Although high levels of c-fos messenger RNA were detectable in a variety of tissues, deregulated c-fos expression specifically interferes with normal bone development without inducing malignant tumours.

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References

  1. Bishop, J. M. & Varmus, H. E. in Molecular Biology of Tumor Viruses, RNA Tumor Viruses, 2nd edn. (eds Weiss, R. A. et al.) 999–1108 (Cold Spring Harbor Laboratory, Cold Spring Harbor, 1982).

    Google Scholar 

  2. Varmus, H. E. A. Rev. Genet. 18, 553–612 (1984).

    Article  CAS  Google Scholar 

  3. Müller, R. Trends Biochem. Sci. 11, 129–132 (1986).

    Article  Google Scholar 

  4. Weinberg, R. A. Trends Biochem. Sci. 9, 131–133 (1984).

    Article  Google Scholar 

  5. Marshall, C. in Molecular Biology of Tumor Viruses, RNA Tumor Viruses II (eds Weiss, R. et al.) 487–558 (Cold Spring Harbor Laboratory, Cold Spring Harbor, 1985).

    Google Scholar 

  6. Wagner, E. F. & Stewart, C. L. in Experimental Approaches to Mammalian Embryonic Development (eds Rossant, J. & Pederson, R. D.) 509–549 (Cambridge University Press 1986).

    Google Scholar 

  7. Hanahan, D. in Oncogenes and Growth Control (eds Kahn, P. & Graf, T.) 349–363 (Springer, Heidelberg, 1986).

    Book  Google Scholar 

  8. Adams, J. R. et al. Nature 318, 533–538 (1985).

    Article  ADS  CAS  Google Scholar 

  9. Müller, R. Biochim. biophys Acta 823, 207–225 (1986).

    PubMed  Google Scholar 

  10. Verma, I. M. Trends Genet. 2, 93–96 (1986).

    Article  CAS  Google Scholar 

  11. Greenberg, M. E. & Ziff, E. M. Nature 311, 433–438 (1984).

    Article  ADS  CAS  Google Scholar 

  12. Kruijer, W., Cooper, J. A., Hunter, T. & Verma, I. M. Nature 312, 711–716 (1984).

    Article  ADS  CAS  Google Scholar 

  13. Müller, R., Bravo, R., Burckhardt, J. & Curran, T. Nature 312, 716–720 (1984).

    Article  ADS  Google Scholar 

  14. Müller, R. & Wagner, E. F. Nature 311, 438–442 (1984).

    Article  ADS  Google Scholar 

  15. Rüther, U., Wagner, E. F. & Müller, R. EMBO J. 4, 1775–1781 (1985).

    Article  Google Scholar 

  16. Müller, R., Verma, I. M. & Adamson, E. D. EMBO J. 2, 679–684 (1983).

    Article  Google Scholar 

  17. Müller, R., Müller, D. & Guilbert, L. EMBO J. 3, 1887–1290 (1984).

    Article  Google Scholar 

  18. Kreipe, H. et al. Differentiation (in the press).

  19. Müller, R., Müller, D., Verrier, B., Bravo, R. & Herbst, H. EMBO J. 5, 311–316 (1986).

    Article  Google Scholar 

  20. Karin, M., et al. Nature 308, 513–519 (1984).

    Article  ADS  CAS  Google Scholar 

  21. Miller, A. D., Curran, T. & Verma, I. M. Cell 36, 51–60 (1984).

    Article  CAS  Google Scholar 

  22. Meijilink, F., Curran, T., Miller, D. A. & Verma, I. M. Proc. natn. Acad. Sci. U.S.A. 82, 4987–4991 (1985).

    Article  ADS  Google Scholar 

  23. Treisman, R. Cell 42, 889–902 (1985).

    Article  CAS  Google Scholar 

  24. Shaw, G. & Kamen, R. Cell 46, 659–667 (1986).

    Article  CAS  Google Scholar 

  25. Brinster, R. L. et al. Cell 27, 223–231 (1981).

    Article  CAS  Google Scholar 

  26. Finkel, M. P., Biskis, B. O. & Jinkins, P. B. Science 151, 698–701 (1966).

    Article  ADS  CAS  Google Scholar 

  27. Finkel, M. P. & Biskis, B. O. Prog. exp. Tumor Res. 10, 72–111 (1968).

    Article  CAS  Google Scholar 

  28. Finkel, M. P., Reilly, C. A., Biskis, B. O. & Greco, I. L. Proc. Symp. Colston Res. Soc. 24, 353–366 (Butterworths, London, 1973).

    Google Scholar 

  29. Ward, J. M. & Young, D. M. Cancer Res. 36, 3985–3992 (1979).

    Google Scholar 

  30. Price, C. H. G., Moore, M. & Jones, D. B. Br. J. Cancer 26, 15–27 (1972).

    Article  CAS  Google Scholar 

  31. Jenuwein, T., Müller, D., Curran, T. & Müller, R. Cell 41, 629–637 (1985).

    Article  CAS  Google Scholar 

  32. Parker, R. C., Varmus, H. E. & Bishop, J. M. Cell 37, 131–139 (1984).

    Article  CAS  Google Scholar 

  33. Spandidos, D. A. & Wilkie, N. M. Nature 310, 469–475 (1984).

    Article  ADS  CAS  Google Scholar 

  34. Sissons, H. A. in The Biochemistry and Physiology of Bone, 2nd edn (ed. Bourne, G. H.) 145–175 (Academic, New York, 1972).

    Google Scholar 

  35. Hanahan, D. Nature 315, 115–122 (1985).

    Article  ADS  CAS  Google Scholar 

  36. Stewart, T. A., Pattengale, P. K. & Leder, P. Cell 38, 627–637 (1984).

    Article  CAS  Google Scholar 

  37. Leder, A., Pattengale, P. K., Kuo, A., Stewart, T. A. & Leder, P. Cell 45, 485–495 (1986).

    Article  CAS  Google Scholar 

  38. Brinster, R. L. et al. Cell 37, 367–379 (1984).

    Article  CAS  Google Scholar 

  39. Lacey, M., Alpert, S. & Hanahan, D. Nature 322, 609–612 (1986).

    Article  ADS  CAS  Google Scholar 

  40. Langdon, W. Y., Harris, A. W., Cory, S. & Adams, J. M. Cell 47, 11–18 (1986).

    Article  CAS  Google Scholar 

  41. Chirgwin, D. M., Przybyla, A. E., MacDonald, R. J. & Rutter, W. Biochemistry 18, 5294–5299 (1979).

    Article  CAS  Google Scholar 

  42. Melton, D. A. et al. Nucleic Acids Res. 12, 7035–7056 (1984).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. Dymitr Komitowski: Institute of Experimental Pathology, German Cancer Research Center, D-6900 Heidelberg, FRG

Authors and Affiliations

  1. European Molecular Biology Laboratory, Postfach 10.2209, D-6900, Heidelberg, FRG

    Ulrich Rüther, Christa Garber, Dymitr Komitowski, Rolf Müller & Erwin F. Wagner

Authors
  1. Ulrich Rüther
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  2. Christa Garber
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  3. Dymitr Komitowski
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  4. Rolf Müller
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  5. Erwin F. Wagner
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Rüther, U., Garber, C., Komitowski, D. et al. Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature 325, 412–416 (1987). https://doi.org/10.1038/325412a0

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  • DOI: https://doi.org/10.1038/325412a0

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