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Mdm2–SUMO1: is bigger better?

Nature Cell Biology volume 2, pages E161–E163 (2000)Cite this article

Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53.

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Figure 1: Reversible protein modification with the ubiquitin-related protein SUMO.
Figure 2: Destructive pathways: SUMOylation of Mdm2 and degradation of p53.

References

  1. Oren, M. J. Biol. Chem. 274, 36031–36034 (1999).

    Article  CAS  Google Scholar 

  2. Momand, J., Wu, H. H. & Dasgupta, G. Gene 242, 15– 29 (2000).

    Article  CAS  Google Scholar 

  3. Buschmann, T., Fuchs, S. Y., Lee, C. C., Pan, Z. Q. & Ronai, Z. Cell 101, 753– 762 (2000).

    Article  CAS  Google Scholar 

  4. Hochstrasser, M. Nature Cell Biol. 2, E153–E157 (2000).

    Article  CAS  Google Scholar 

  5. Yeh, E. T., Gong, L. & Kamitani, T. Gene 248, 1– 14 (2000).

    Article  CAS  Google Scholar 

  6. Melchior, F. Annu. Rev. Cell Dev. Biol. 16, 591– 626 (2000).

    Article  CAS  Google Scholar 

  7. Jentsch, S. & Pyrowolakis, G. Trends Cell Biol. 10, 335–342 (2000).

    Article  CAS  Google Scholar 

  8. Selter, H., Amela-Neuschwander, S., Villena-Heinsen, C. & Montenarh, M. Cancer Lett. 96, 111–115 (1995).

    Article  CAS  Google Scholar 

  9. Sharp, D. A., Kratowicz, S. A., Sank, M. J. & George, D. L. J. Biol. Chem. 274, 38189–38196 (1999).

    Article  CAS  Google Scholar 

  10. Lohrum, M. A., Ashcroft, M., Kubbutat, M. H. & Vousden, K. H. Nature Cell Biol. 2, 179–181 (2000).

    Article  CAS  Google Scholar 

  11. Podust, V. N. et al. Proc. Natl Acad. Sci. USA 97, 4579– 4584 (2000).

    Article  CAS  Google Scholar 

  12. Tanimura, S. et al. FEBS Lett. 447, 5– 9 (1999).

    Article  CAS  Google Scholar 

  13. Hsieh, J. K. et al. Mol. Cell 3, 181–193 (1999).

    Article  CAS  Google Scholar 

  14. Grossman, S. R. et al. Mol. Cell 2, 405–415 (1998).

    Article  CAS  Google Scholar 

  15. Honda, R. & Yasuda, H. EMBO J. 18, 22–27 (1999).

    Article  CAS  Google Scholar 

  16. Erhardt, P., Tomaselli, K. J. & Cooper, G. M. J. Biol. Chem. 272, 15049– 15052 (1997).

    Article  CAS  Google Scholar 

Download references

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  1. the Max Planck Institute for Biochemistry, Am Klopferspitz 18a, Martinsried, 82152, Germany

    Frauke Melchior & Ludger Hengst

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  1. Frauke Melchior
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  2. Ludger Hengst
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Melchior, F., Hengst, L. Mdm2–SUMO1: is bigger better?. Nat Cell Biol 2, E161–E163 (2000). https://doi.org/10.1038/35023639

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