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Surfing the p53 network

Nature volume 408, pages 307–310 (2000)Cite this article

The p53 tumour-suppressor gene integrates numerous signals that control cell life and death. As when a highly connected node in the Internet breaks down, the disruption of p53 has severe consequences.

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Figure 1
Figure 2: Viral oncogenes and the p53 network.
Figure 3: The p53 network.

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Author information

Authors and Affiliations

  1. The Howard Hughes Medical Institute and Johns Hopkins Oncology Center, Baltimore, 21231, Maryland , USA

    Bert Vogelstein

  2. Department of Surgery and Molecular Oncology, Ninewells Hospital, University of Dundee, Dundee, DD1 5EH, UK

    David Lane

  3. Laboratory of Cancer Biology, Genetics, and Molecular Biophysics, Rockefeller University, 1230 York Avenue, New York, 10021 , New York, USA

    Arnold J. Levine

Authors
  1. Bert Vogelstein
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  2. David Lane
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  3. Arnold J. Levine
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Corresponding authors

Correspondence to Bert Vogelstein, David Lane or Arnold J. Levine.

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Vogelstein, B., Lane, D. & Levine, A. Surfing the p53 network. Nature 408, 307–310 (2000). https://doi.org/10.1038/35042675

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