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Effects of an Rb mutation in the mouse

Nature volume 359, pages 295–300 (1992)Cite this article

Abstract

The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.

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Author notes

  1. Tyler Jacks & Earlene M. Schmitt

    Present address: Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

Authors and Affiliations

  1. Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA

    Tyler Jacks, Amin Fazeli, Earlene M. Schmitt, Margaret A. Goodell & Robert A. Weinberg

  2. Department of Pathology, Tufts University Schools of Medicine and Veterinary Medicine, Boston, Massachusetts, 02111, USA

    Roderick T. Bronson

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  1. Tyler Jacks
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  2. Amin Fazeli
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  3. Earlene M. Schmitt
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  4. Roderick T. Bronson
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  5. Margaret A. Goodell
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  6. Robert A. Weinberg
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Jacks, T., Fazeli, A., Schmitt, E. et al. Effects of an Rb mutation in the mouse. Nature 359, 295–300 (1992). https://doi.org/10.1038/359295a0

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