Abstract
THE autosomal recessive mouse mutation reeler1–3 leads to impaired motor coordination, tremors and ataxia4. Neurons in affected mice fail to reach their correct locations in the developing brain, disrupting the organization of the cerebellar and cerebral cortices and other laminated regions5–8. Here we use a previously characterized reeler allele (rltg)9 to clone a gene, reelin, deleted in two reeler alleles. Normal but not mutant mice express reelin in embryonic and postnatal neurons during periods of neuronal migration. The encoded protein resembles extracellular matrix proteins involved in cell adhesion. The reeler phenotype thus seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
196,21 € per year
only 3,85 € per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dernoncourt, C., Ruelle, D. & Goffinet, A. M. Genomics 11, 1167–1169 (1991).
Bar, I. et al. Genomics (in the press).
Montgomery, J. C., Guamieri, M. H., Tartaglia, K. E. & Flaherty, L. A. Mamm. Genome (in the press).
Falconer, D. S. J. Genet. 50, 192–201 (1951).
Hamburgh, M. Devl Biol. 8, 165–185 (1963).
Mariani, J., Crepel, F., Mikoshiba, K., Changeux, J. P. & Sotelo, C. Phil. Trans. R. Soc. B281, 1–28 (1977).
Caviness, V. S. J. & Rakic, P. A. Rev. Neurosci. 1, 297–326 (1978).
Goffinet, A. M. Int. J. devl Biol. 36, 101–107 (1992).
Miao, G. G. et al. Proc. natn. Acad. Sci. U.S.A. 91, 11050–11054 (1994).
Buckler, A. J. et al. Proc. natn. Acad. Sci. U.S.A. 88, 4005–4009 (1991).
Kozak, M. J.Cell Biol. 115, 887–903 (1991).
Heijne, V. J. Molec. Biol. 173, 243–251 (1984).
Bourdon, M. A., Krusius, T., Campbell, S., Schwartz, N. B. & Ruoslahti, E. Proc. natn. Acad. Sci. U.SA. 84, 3194–3198 (1987).
Klar, A., Baldassare, M. & Jessel, T. M. Cell 69, 95–110 (1992).
Engel, J. FEBS Lett. 251, 1–7 (1989).
Goffinet, A. M. Brain Res. 319, 261–296 (1984).
Derer, P. & Nakanishi, S. J. Hirnforsch. 24, 209–224 (1983).
Godfraind, C., Schachner, M. & Goffinet, A. M. Brain Res. 470, 99–111 (1988).
Stanfield, B. B. & Cowan, W. M. J. comp. Neurol. 185, 461–484 (1979).
Terashima, T., Inoue, K., lnoue, Y., Yokoyama, M. & Mikoshiba, K. J. comp. Neurol. 252, 264–278 (1986).
Guenet, J.-L. Mouse News Lett. 41, (1981).
Flaherty, L., Messer, A., Russell, L. B. & Rinchik, E. M. Proc. natn. Acad. Sci. U.S.A. 89, 2859–2863 (1992).
Franco, B. et al. Nature 353, 529–536 (1991).
Legouis, R. et al. Cell 67, 423–435 (1991).
Mischel, P. S., Nguyen, L. P. & Vinters, H. V. J. Neuropath. exp. Neurol. 54, 137–153 (1995).
Xanthoudakis, S., Miao, G., Wang, F., Pan, Y.-C. E. & Curran, T. EMBO J. 11, 3323–3335 (1992).
Cathala, G. et al. DNA 2, 329–335 (1983).
Lugo, D. I., Roberts, J. L. & Pintar, J. E. Molec. Endocrin. 3, 1313–1324 (1989).
Simmons, D. M., Arriza, J. L. & Swanson, L. W. J. Histotechn. 12, 169–181 (1989).
Ogawa, et al. Neurons (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
D'Arcangelo, G., G. Miao, G., Chen, SC. et al. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature 374, 719–723 (1995). https://doi.org/10.1038/374719a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/374719a0
