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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Nature volume 383, pages 407–413 (1996)Cite this article

Abstract

Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs. Early defects are observed in the establishment or maintenance of midline structures, such as the notochord and the floorplate, and later defects include absence of distal limb structures, cyclopia, absence of ventral cell types within the neural tube, and absence of the spinal column and most of the ribs. Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres.

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Authors and Affiliations

  1. Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland, 20892, USA

    Chin Chiang, Ying Litingtung, Eric Lee & Heiner Westphal

  2. Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Chin Chiang, Ying Litingtung, Keith E. Young, Jeffrey L Corden & Philip A. Beachy

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  1. Chin Chiang
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  7. Philip A. Beachy
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Chiang, C., Litingtung, Y., Lee, E. et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407–413 (1996). https://doi.org/10.1038/383407a0

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