A major hurdle in treating cancer is that tumour cells acquire drug resistance. To overcome this problem, one strategy might be to fine-tune the right mixture of drugs that target specific molecules.
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References
Sawyers, C. L. Genes Dev. 17, 2998–3010 (2003).
Engelman, J. A. et al. Science 316, 1039–1043 (2007).
Stommel, J. M. et al. Science 318, 287–290 (2007).
Pao, W. et al. PLoS Med. 2, e73 (2005).
Michor, F. et al. Nature 435, 1267–1270 (2005).
Skaggs, B. J. et al. Proc. Natl Acad. Sci. USA 103, 19466–19471 (2006).
Shah, N. P. et al. Cancer Cell 2, 117–125 (2002).
Shah, N. P. et al. J. Clin. Invest. 117, 2562–2569 (2007).
Talpaz, M. et al. N. Engl. J. Med. 354, 2531–2541 (2006).
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Sawyers, C. Mixing cocktails. Nature 449, 993–995 (2007). https://doi.org/10.1038/449993a
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DOI: https://doi.org/10.1038/449993a
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