When scientists opened up the human genome, they expected to find the genetic components of common traits and diseases. But they were nowhere to be seen. Brendan Maher shines a light on six places where the missing loot could be stashed away.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
196,21 € per year
only 3,85 € per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Visscher, P. M. Nature Genet. 40, 489–490 (2008).
Weedon, M. N. et al. Nature Genet. 40, 575–583 (2008).
Lettre, G. et al. Nature Genet. 40, 584–591 (2008).
Gudbjartsson, D. F. et al. Nature Genet. 40, 609–615 (2008).
Sullivan, P. F. PLoS Med. 2, e212 (2005).
Freitag, C. M. Mol. Psychiatr. 12, 2–22 (2007).
Romeo, S. et al. Nature Genet. 39, 513–516 (2007).
Stefansson, H. et al. Nature 455, 232–237 (2008).
The International Schizophrenia Consortium Nature 455, 237–241 (2008).
Brem, R. B., Yvert, G., Clinton, R. & Kruglyak, L. Science 296, 752–755 (2002).
Waterland, R. A. & Jirtle, R. L. Mol. Cell. Biol. 23, 5293–5300 (2003).
Lam, M. Y., Heaney, J. D., Youngren, K. K., Kawasoe, J. H. & Nadeau, J. H. Hum. Mol. Genet. 16, 2233–2240 (2007).
Related links
Rights and permissions
About this article
Cite this article
Maher, B. Personal genomes: The case of the missing heritability. Nature 456, 18–21 (2008). https://doi.org/10.1038/456018a
Published:
Issue Date:
DOI: https://doi.org/10.1038/456018a
