Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views Forum
  • Published:

Immunology

Allergy challenged

An article suggesting that allergic responses may not be an accident of an off-target immune system, but rather a deliberate defence against potential harm, provokes the question of whether our understanding of allergy needs an overhaul. Immunologists provide their opinions. See Perspective p.465

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The serpent or the worm?

WELLCOME LIBRARY, LONDON

References

  1. Palm, N. W., Rosenstein, R. K. & Medzhitov, R. Nature 484, 465–472 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Akahoshi, M. et al. J. Clin. Invest. 121, 4180–4191 (2011).

    Article  CAS  Google Scholar 

  3. Fitzsimmons, C. M. & Dunne, D. W. Trends Parasitol. 25, 447–451 (2009).

    Article  Google Scholar 

  4. Valenzuela, J. G. et al. J. Exp. Biol. 205, 2843–2864 (2002).

    CAS  PubMed  Google Scholar 

  5. Finkelman, F. D. et al. Annu. Rev. Immunol. 15, 505–533 (1997).

    Article  CAS  Google Scholar 

  6. Hoffman, D. R., Wood, C. L. & Hudson, P. J. Allergy Clin. Immunol. 71, 193–196 (1983).

    Article  CAS  Google Scholar 

  7. Matsuda, H. et al. J. Immunol. 144, 259–262 (1990).

    CAS  PubMed  Google Scholar 

  8. Owor, R. & Wamukota, W. M. Trans. R. Soc. Trop. Med. Hyg. 70, 497–499 (1976).

    Article  CAS  Google Scholar 

  9. Herbert, D. R. et al. J. Immunol. 184, 6438–6446 (2010).

    Article  CAS  Google Scholar 

  10. Chen, F. et al. Nature Med. 18, 260–266 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to David Artis, Rick M. Maizels or Fred D. Finkelman.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Artis, D., Maizels, R. & Finkelman, F. Allergy challenged. Nature 484, 458–459 (2012). https://doi.org/10.1038/484458a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/484458a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing