A survey of market trends for biotech products shows that only a handful out of more than one hundred biologics have been fueling the double-digit rise in revenues in the sector.
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References
Miller, H.I. As biotech turns 20. Nat. Rev. Drug Discov. 1, 1007–1008 (2002).
Walsh, G. Biopharmaceutical benchmarks 2006. Nat. Biotechnol. 24, 769–776 (2006).
Remuzzi, G. & Ingelfinger, J.R. Correction of anemia–payoffs and problems. N. Engl. J. Med. 355, 2144–2146 (2006).
Khuri, F.R. Weighing the hazards of erythropoiesis stimulation in patients with cancer. N. Engl. J. Med. 356, 2445–2448 (2007).
Dooren, J.C. Medicare may limit anemia drug money: payment eligibility would be narrowed; Amgen J&J Impact. Wall Street Journal D.2 (May 15, 2007).
Chase, M. A victory for anemia patients? Advocates beat back efforts to limit use of the popular drugs that carry heart risks. Wall Street Journal D.1 (July 31, 2007)
Senior, M. Why EPO matters. In Vivo, 18–24 (July/August 2006).
Reichert, J.M. & Valge-Archer, V.E. Development trends for monoclonal antibody cancer therapeutics. Nat. Rev. Drug Discov. 6, 349–356 (2007).
Reichert, J. & Pavolu, A. Monoclonal antibodies market. Nat. Rev. Drug Discov. 3, 383–384 (2004).
Mount, C. & Featherstone, J. Rheumatoid arthritis market. Nat. Rev. Drug Discov. 4, 11–12 (2005).
Bain, B. & Brazil, M. Adalimumab. Nat. Rev. Drug Discov. 2, 693–694 (2003).
Michels, S., Rosenfeld, P.J., Puliafito, C.A., Marcus, E.N. & Venkatraman, A.S. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration: twelve-week results of an uncontrolled open-label clinical study. Ophthalmology 112, 1035–1047 (2005).
Steinbrook, R. The price of sight–ranibizumab, bevacizumab, and the treatment of macular degeneration. N. Engl. J. Med. 355, 1409–1412 (2006).
Hirsch, I.B. Insulin analogues. N. Engl. J. Med. 352, 174–183 (2005).
Arlene, W. From Pfizer, Irrational Exubera? Bus. Week, p. 32 (July 16, 2006).
Rother, K.I. Diabetes treatment–bridging the divide. N. Engl. J. Med. 356, 1499–1501 (2007).
Davidson, S. Biogen, Serono squabble over MS market. Nat. Biotechnol. 19, 696–697 (2001).
Dzik, W.H. Off-label reports of new biologics: exciting new therapy or dubious research? Examples from recombinant activated factor VII. J. Intensive Care Med. 21, 54–59 (2001).
Anand, G. Why Genzyme can charge so much for Cerezyme. Wall St. J. (East Ed.), A15 (November 16, 2005).
Abbott, A. Lyme disease: uphill struggle. Nature 439, 524–525 (2006).
Glass, R.I., Bresee, J.S., Parashar, U.D., Jiang, B. & Gentsch, J. The future of rotavirus vaccines: a major setback leads to new opportunities. Lancet 363, 1547–1550 (2004).
Thomas, M.B. Lilly's Xigris drug to treat infection had FDA approval. Wall Street Journal B.5 (Nov. 23, 2001).
Schrag, D. The price tag on progress–chemotherapy for colorectal cancer. N. Engl. J. Med. 351, 317–319 (2004).
Opal, S.M. Can we resolve the treatment of sepsis? Lancet 369, 803–804 (2007).
Booth, B.L. & Zemmel, R.W. The search for blockbuster drugs. The McKinsey Quarterly (August 2004). Web exclusive http://www.mckinseyquarterly.com/ The_search_for_blockbuster_drugs_1474_abstract
Cohen, R.G. Entry order as consideration of follow-on biologics. N. Eng. J. Med. 357, 841–843 (2007).
Frank, R.G. Regulation of follow-on biologics. N. Engl. J. Med. 357, 841–843 (2007).
Woodcock, J. et al. The FDA's assessment of follow-on protein products: a historical perspective. Nat. Rev. Drug Discov. 6, 437–442 (2007).
Acknowledgements
S.A. thanks the affiliated institutions for access to journals and news articles. S.A. also thanks Ozlem Topaloglu (Johns Hopkins), Samuel R. Denmeade (Johns Hopkins), Kevin Fitzpatrick (IMS Health), Nitin Patel (IMS Health) and Chris Francis (IMS Health) for insightful discussions. This manuscript was submitted to Nature Biotechnology in June, 2007.
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Aggarwal, S. What's fueling the biotech engine?. Nat Biotechnol 25, 1097–1104 (2007). https://doi.org/10.1038/nbt1007-1097
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DOI: https://doi.org/10.1038/nbt1007-1097