Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides

Nature Genetics volume 40, pages 149–151 (2008)Cite this article

Abstract

We tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with replication in 10,536 subjects. We found association of a nonsynonymous SNP (rs3812316, G771C, Gln241His) in MLXIPL with plasma triglyceride levels (combined P = 1.4 × 10−10). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Genomic context of the MLXIPL region on chromosome 7q11.23.

Similar content being viewed by others

References

  1. Despres, J.P. & Lemieux, I. Nature 444, 881–887 (2006).

    Article  CAS  Google Scholar 

  2. Ordovas, J.M. Cardiovasc. Drugs Ther. 16, 273–281 (2002).

    Article  CAS  Google Scholar 

  3. Zeggini, E. et al. Science 316, 1336–1341 (2007).

    Article  CAS  Google Scholar 

  4. Frayling, T.M. et al. Science 316, 889–894 (2007).

    Article  CAS  Google Scholar 

  5. Romeo, S. et al. Nat. Genet. 39, 513–516 (2007).

    Article  CAS  Google Scholar 

  6. Saxena, R. et al. Science 316, 1331–1336 (2007).

    Article  CAS  Google Scholar 

  7. Patil, N. et al. Science 294, 1719–1723 (2001).

    Article  CAS  Google Scholar 

  8. Price, A.L. et al. Nat. Genet. 38, 904–909 (2006).

    Article  CAS  Google Scholar 

  9. Bacanu, S.A., Devlin, B. & Roeder, K. Am. J. Hum. Genet. 66, 1933–1944 (2000).

    Article  CAS  Google Scholar 

  10. LaRosa, J.C. et al. N. Engl. J. Med. 352, 1425–1435 (2005).

    Article  CAS  Google Scholar 

  11. Fisher, R.A. Statistical Methods for Research Workers edn. 13 (Oliver & Boyd, London, 1925).

    Google Scholar 

  12. Uyeda, K. & Repa, J.J. Cell Metabolism 4, 107–110 (2006).

    Article  CAS  Google Scholar 

  13. Ma, L., Robinson, L.N. & Towle, H.C. J. Biol. Chem. 281, 28721–28730 (2006).

    Article  CAS  Google Scholar 

  14. Li, M.V., Chang, B., Imamura, M., Poungvarin, N. & Chan, L. Diabetes 55, 1179–1189 (2006).

    Article  CAS  Google Scholar 

  15. Diamond, J. Nature 423, 599–602 (2003).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

At Ealing Hospital and Imperial College we thank J. Wrigley, S. Trainor and the team of research nurses for their excellent subject characterization and for sample handling, and D. Kalaitzopoulos, X. Li and P. Thomason for assistance with data analysis. At Pfizer we thank L.S. Wood, M.E. Lira and A.R. Mank-Seymour for their help, and D.S. Lee for strategic input. At Instituto Nacional de Ciencias Médicas y Nutrición, we thank O. Leyva, U. Alvirde, M.A. Melgarejo, L.E. Guillén, C. Moreno, C. Gonzalez, M.L. Velasco-Pérez and A. Velásquez for help with data collection, blood analysis and sample shipment. At Perlegen Sciences we thank L. Stuve, the laboratory group, R. Stokowski, the samples group, J. Sheehan, the data quality group, D. Ballinger, and the analysis and data pipeline group for excellent technical and infrastructural support and E. Beilharz for manuscript preparation. J.S.K., J.C.C., P.E. and J.S. were supported by the British Heart Foundation Grant SP/04/002.

Author information

Author notes

  1. Gregory R Warnes & Patrice M Milos

    Present address: Current address: Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 14642, USA (G.R.W.); Helicos BioSciences, Cambridge, Massachusetts 02139, USA (P.M.M.).,

  2. Jaspal S Kooner and John C Chambers: These authors contributed equally to this work.

Authors and Affiliations

  1. National Heart and Lung Institute, Imperial College London, UK

    Jaspal S Kooner & James Scott

  2. Department of Epidemiology and Public Health, Imperial College London, UK

    John C Chambers & Paul Elliott

  3. Instituto Nacional de Ciencias Médicas y Nutrición, Vasco de Quiroga 15, México City, 14000, México

    Carlos A Aguilar-Salinas & Francisco J Gómez Pérez

  4. Perlegen Sciences, Inc., 2021 Stierlin Court, Mountain View, 94043, California, USA

    David A Hinds, Kelly A Frazer & David R Cox

  5. Pfizer Global Research and Development, Groton, 06340, Connecticut, USA

    Craig L Hyde, Gregory R Warnes, Patrice M Milos & John F Thompson

Authors
  1. Jaspal S Kooner
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. John C Chambers
    View author publications

    You can also search for this author inPubMed Google Scholar

  3. Carlos A Aguilar-Salinas
    View author publications

    You can also search for this author inPubMed Google Scholar

  4. David A Hinds
    View author publications

    You can also search for this author inPubMed Google Scholar

  5. Craig L Hyde
    View author publications

    You can also search for this author inPubMed Google Scholar

  6. Gregory R Warnes
    View author publications

    You can also search for this author inPubMed Google Scholar

  7. Francisco J Gómez Pérez
    View author publications

    You can also search for this author inPubMed Google Scholar

  8. Kelly A Frazer
    View author publications

    You can also search for this author inPubMed Google Scholar

  9. Paul Elliott
    View author publications

    You can also search for this author inPubMed Google Scholar

  10. James Scott
    View author publications

    You can also search for this author inPubMed Google Scholar

  11. Patrice M Milos
    View author publications

    You can also search for this author inPubMed Google Scholar

  12. David R Cox
    View author publications

    You can also search for this author inPubMed Google Scholar

  13. John F Thompson
    View author publications

    You can also search for this author inPubMed Google Scholar

Contributions

J.S.K., J.C.C., C.A.A.-S. and F.J.G.P. supervised patient recruitment and phenotyping. K.A.F. and J.F.T. supervised the experiments and, with J.S.K., J.S., D.R.C. and P.M.M., designed the study. D.A.H., C.L.H., G.R.W. and D.R.C. performed data analysis. J.S.K., J.C.C., P.E., P.M.M., J.S., K.A.F., D.A.H., D.R.C. and J.F.T. wrote the manuscript.

Corresponding author

Correspondence to Jaspal S Kooner.

Ethics declarations

Competing interests

D.C.C. and D.A.H. are employees of Perlegen Sciences, Inc., J.F.T. and C.L.H. of Pfizer Inc., and P.M.M. of Helicos BioSciences.

Supplementary information

Supplementary Text and Figures

Supplementary Methods, Supplementary Figure 1 and Supplementary Tables 1–5 (PDF 597 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kooner, J., Chambers, J., Aguilar-Salinas, C. et al. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet 40, 149–151 (2008). https://doi.org/10.1038/ng.2007.61

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.2007.61

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing