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Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33

Nature Genetics volume 9, pages 80–85 (1995)Cite this article

Abstract

The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage disequilibrium at 21 microsatellite marker loci, using 348 affected sibpair families and 107 simplex families. The microsatellite D2S152 was linked to, and associated with, disease in families from three different populations. Our evidence localizes a new diabetes susceptibility gene, IDDM7, to within two centiMorgans of D2S152. This places it in a region of chromosome 2q that shows conserved synteny with the region of mouse chromosome 1 containing the murine type 1 diabetes gene, Idd5. These results demonstrate the utility of polymorphic microsatellites for linkage disequilibrium mapping of genes for complex diseases.

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Authors and Affiliations

  1. Nuffield Department of Surgery, The Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Oxford, OX3 7BN, UK

    J.B. Copeman, F. Cucca, C.M. Hearne, R.J. Cornall, P.W. Reed & J.A. Todd

  2. Institute of Transplantation Immunology, National Hospital, Oslo, 0027, Norway

    K.S. Rønningen & D.E. Undlien

  3. Istituto Clinica Medica II, Università di Roma La Sapienza, Rome, Italy

    L. Nisticò & R. Buzzetti

  4. Istituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche, Rome, Italy

    R. Tosi

  5. Steno Diabetes Center, Gentofte, DK-2820, Denmark

    F. Pociot & J. Nerup

  6. INSERM U. 358, Hôspital St Louis, Bâtiment INSERM, 12 rue de la Grange aux Belles, 75010, Paris, France

    F. Cornélis

  7. Department of Medicine/Diabetes/Endocrinology, University of Birmingham, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, UK

    A.H. Barnett & S.C. Bain

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Copeman, J., Cucca, F., Hearne, C. et al. Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33. Nat Genet 9, 80–85 (1995). https://doi.org/10.1038/ng0195-80

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