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Inborn variation in metabolism

Nature Genetics volume 42, pages 97–98 (2010)Cite this article

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Advances in analytical biochemistry have recently made it possible to obtain global snapshots of metabolism. A new study couples such technology with genome-wide genetic analysis to explore inherited variation in human metabolism.

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Figure 1: Mendelian randomization experiment to test whether genetic alteration of a metabolic pathway plays a causal role in disease.

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Author information

Authors and Affiliations

  1. Vamsi K. Mootha is at the Harvard Medical School Department of Systems Biology, Massachusetts General Hospital, Boston, and the Broad Institute Metabolism Initiative, Cambridge, Massachusetts, USA.,

    Vamsi K Mootha

  2. Joel N. Hirschhorn is at the Harvard Medical School Department of Genetics, Children's Hospital, Boston, and the Broad Institute Metabolism Initiative, Cambridge, Massachusetts, USA.,

    Joel N Hirschhorn

Authors
  1. Vamsi K Mootha
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  2. Joel N Hirschhorn
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Correspondence to Vamsi K Mootha or Joel N Hirschhorn.

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Mootha, V., Hirschhorn, J. Inborn variation in metabolism. Nat Genet 42, 97–98 (2010). https://doi.org/10.1038/ng0210-97

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