New evidence suggests that Wnt signaling can be suppressed or further activated by upstream signals, even though the pathway seems to be constitutively activated by downstream mutations in cancer cells.
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Taketo, M. Shutting down Wnt signal–activated cancer. Nat Genet 36, 320–322 (2004). https://doi.org/10.1038/ng0404-320
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DOI: https://doi.org/10.1038/ng0404-320
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