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Evidence for a susceptibility locus for schizophrenia on chromosome 6pter–p22

Nature Genetics volume 10, pages 41–46 (1995)Cite this article

Abstract

We have performed linkage analysis in 186 multiplex families to search for genes that predispose to schizophrenia. Under a model with partially dominant inheritance, moderately broad disease definition and assuming locus homogeneity, a lod score of 3.2 was obtained for D6S260 on chromosome 6p23. A multipoint lod score of 3.9 (P=2.3 × 10−5) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity. Adjusted for testing of multiple models, the multipoint lod score of 3.9 under heterogeneity has a genome wide significance of between 5–8%. The non–parametric affected pedigree member test provided results (P=3 × 10−4) also supporting this finding. Our findings provide supportive evidence for a susceptibility locus for schizophrenia orr distal chromosome 6p, and support a model of locus heterogeneity.

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Authors and Affiliations

  1. Molecular Epidemiology and Disease Indicators Branch, NIDR, Bethesda, Maryland, 20892, USA

    Shengbiao Wang, Cui-e Sun, Cynthia A. Walczak & Scott R. Diehl

  2. Applied Biosystems Division, Perkin Elmer Corp., Foster City, California, 94404, USA

    Janet S. Ziegle

  3. Clinical Research Center for Periodontal Diseases, School of Dentistry, Virginia Commonwealth University, Richmond, Virginia, 23298, USA

    Barbara R. Kipps

  4. Clinical Neurogenetics Branch, NIMH, Bethesda, Maryland, 20892, USA

    Lynn R. Goldin

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Wang, S., Sun, Ce., Walczak, C. et al. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter–p22. Nat Genet 10, 41–46 (1995). https://doi.org/10.1038/ng0595-41

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